2025
conference-paper
OpenAlex
Fabian Kellermeier, M Kappelmeyer, Katja Dettmer‐Wilde, Peter J. Oefner et autres
Introduction Estetrol (E4), a natural estrogen uniquely synthesized prenatally by the fetal liver, preferentially binds estrogen receptor α (ESR1). Unlike other estrogens, E4 does not bind to the sex hormone-binding globulin (SHBG). Its estrogenic function is disabled by conjugation with glucuronic acid …
de, at
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2025
article
OpenAlex
Jan Schueler, Simon Heckscher, Nicolas A. Ihlo, Fabian Kellermeier et autres
Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disorder. It is characterized by progressive renal cyst formation, often leading to end-stage kidney disease (ESKD) requiring kidney replacement therapy. In contrast to the urinary metabolome in ADPKD, the …
de
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Accès ouvert
2025
article
OpenAlex
Sophie Pehl, Tobias Hundhammer, Julia Rimboeck, Richard F. Kraus et autres
To investigate granulocytes under laboratory conditions, centrifugation steps are typically required for the isolation of neutrophil granulocytes from whole blood. However, only a few studies to date have addressed the direct effects of centrifugation itself on the functional state of neutrophils. This …
de
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Accès ouvert
2025
article
OpenAlex
Simon Heckscher, Nicolas A. Ihlo, Jan Schueler, Fabian Kellermeier et autres
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disorder characterized by progressive renal cyst formation, often leading to end-stage kidney disease (ESKD). In contrast to the urinary metabolome in ADPKD, the composition of renal cyst fluid remains …
de
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Accès ouvert
2025
article
OpenAlex
Tim Tucholski, Angela Maennel, Yacoub Abelard Njipouombe Nsangou, Sven Schuchardt et autres
BACKGROUND: The growing number of metabolomics studies, based on high-dimensional data measured by hyphenated mass spectrometry (MS) and/or nuclear magnetic resonance (NMR) spectroscopy, has sparked the creation of several public metabolomics data repositories. Each repository emphasizes different aspects regarding data selection and …
de
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Accès ouvert
2024
article
OpenAlex
Md Nur A Alam Siddique, Fabian Kellermeier, Martha Ölke, Mingming Zhao et autres
Aconitate decarboxylase-1 (ACOD1) is expressed by activated macrophages and generates itaconate that exerts anti-microbial and immunoregulatory effects. ACOD1-itaconate is essential for macrophage-mediated control of the intracellular pathogen Coxiella (C.) burnetii, which causes Q fever. Two isomers of itaconate, mesaconate and citraconate, have …
de
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Accès ouvert
2024
erratum
OpenAlex
Fadi Fadil, Claudia Samol, Raffaela S. Berger, Fabian Kellermeier et autres
It was pointed out to us that we had not followed exactly the IROA TruQuant IQQ Workflow Kit protocol in the experimental part of our work [...].
de
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Accès ouvert
2023
article
OpenAlex
Nathalie Babl, Sonja-Maria Decking, Florian Voll, Michael Althammer et autres
BACKGROUND & AIMS: Intratumoral lactate accumulation and acidosis impair T-cell function and antitumor immunity. Interestingly, expression of the lactate transporter monocarboxylate transporter (MCT) 4, but not MCT1, turned out to be prognostic for the survival of patients with rectal cancer, indicating that …
de
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Accès ouvert
2023
article
OpenAlex
Johanna Grund, Katharina Iben, Sarah Reinke, Ina Bühnen et autres
B-cell content in the tumour microenvironment (TME) of classic Hodgkin lymphoma (HL) is known to be associated with prognosis. Here we demonstrate that whole slide image analysis using routinely available slides predicts outcomes in patients treated with ABVD in a prospective trial …
de, us
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Accès ouvert
2022
article
OpenAlex
Fadi Fadil, Claudia Samol, Raffaela S. Berger, Fabian Kellermeier et autres
Metabolic fingerprinting by mass spectrometry aims at the comprehensive, semiquantitative analysis of metabolites. Isotope dilution, if successfully implemented, may provide a more reliable, relative quantification. Therefore, the 13C labeled yeast extract of the IROA TruQuant kit was added as an internal standard …
de
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Accès ouvert
2018
article
OpenAlex
Zaigham Shahzad, Fabian Kellermeier, Emily May Armstrong, Simon Rogers et autres
If we want to understand how the environment has shaped the appearance and behavior of living creatures, we need to compare groups of individuals that differ in genetic makeup and environment experience. For complex phenotypic features, such as body posture or facial …
gb, de, be
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Accès ouvert
2014
article
OpenAlex
Fabian Kellermeier, Patrick Armengaud, Triona J. Seditas, John Danku et autres
As plant roots forage the soil for food and water, they translate a multifactorial input of environmental stimuli into a multifactorial developmental output that manifests itself as root system architecture (RSA). Our current understanding of the underlying regulatory network is limited because …
gb, fr
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