Vathany Kulasingam

Updated total calcium reference intervals for Abbott Alinity c using Calcium2 reagents

Yasser Tabana, Vathany Kulasingam, Tobias Fischer, David Daghfal et autres

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PA-373 Prospective Study of Peripheral Residual Disease (PRD) Monitoring by Clonotypic Mass Spectrometry (EasyM) in patients with Newly Diagnosed Multiple Myeloma (NDMM)

Rintu Sharma, Esther Masih‐Khan, Harjot Vohra, Sita Bhella et autres

Feasibility of improving sLe(a)/CA 19-9 harmonization by recalibration: a simulation study using three EQA programs

Huub H. van Rossum, Stefan Holdenrieder, Junghan Song, Catharine M. Sturgeon et autres

OBJECTIVES: The CA 19-9 tumor marker measures the sialylated Lewis a blood group antigen (sLe(a)) expressed on circulating proteins. CA 19-9 is primarily used to monitor pancreatic and gastrointestinal cancers. Studies have demonstrated the lack of comparability of CA 19-9 assays. METHODS: …

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Beyond Affinity and Amplification: SPARK-seq and the Future of Clinical Laboratory Medicine

Vathany Kulasingam, Miyo K. Chatanaka, Eleftherios P. Diamandis

For decades, clinical laboratory medicine has relied on a limited set of molecular recognition strategies—principally antibodies, nucleic acid hybridization, and mass spectrometry—to translate biological signals into clinically actionable measurements. While these technologies have enabled remarkable advances in diagnostics and therapeutics, each faces …

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MaxQuant Analysis Guide

Felix Leung, Marcus Q. Bernardini, Kun Liang, Ihor Batruch et autres

MaxQuant Analysis

Felix Leung, Marcus Q. Bernardini, Kun Liang, Ihor Batruch et autres

File containing the raw data and a table of contents for the data file.

Angela W.S. Fung, Michael J. Knauer, Ivan M. Blasutig, David Colantonio et autres

Background: Therapeutic drug monitoring of immunosuppressant drugs are used to monitor drug efficacy and toxicity and to prevent organ transplantation rejection. This study evaluates the analytical performance of semi-automated electrochemiluminescence immunoassays (ECLIA) for cyclosporine (CSA), tacrolimus (TAC) and sirolimus (SRL) on the …

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Sensitive peripheral residual disease (PRD) detection using clonotypic mass spectrometry (EasyM) in patients with newly diagnosed multiple myeloma (NDMM)

Rintu Sharma, Esther Masih‐Khan, Harjot Singh Vohra, Sita Bhella et autres

Abstract Background: Achieving minimal residual disease (MRD) negative status has been associated with favourable outcomes confirming its utility as a reliable surrogate marker for progression free survival (PFS) and overall survival (OS). The current methods include next generation sequencing (NGS) or next …

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B-361 Method Validation of Human Chorionic Gonadotropin (hCG) and a-Fetoprotein (AFP) in Cerebrospinal Fluid (CSF)

Yinghua Qiu, Andrew A. Li, Abisha Ganeshamoorthy, Vathany Kulasingam et autres

Abstract Background Intracranial germ cell tumors (GCTs), accounting for 2%–3% of pediatric brain tumors, are diagnostically challenging. GCTs are classified into germinomas and nongerminomatous germ-cell tumors (NGGCTs), which include yolk sac tumors, choriocarcinomas, and mixed tumors. Neuroimaging alone often cannot differentiate GCTs …

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A-121 Analytical performance evaluation of the next generation Abbott enzyme assays on the Alinity c system

Meshach Asare-Werehene, Pow Lee Cheng, Xiaoyan Wang, Marvin Berman et autres

Abstract Background Liver enzyme assays, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), and alkaline phosphatase (ALP), are essential in clinical laboratories for assessing liver function, diagnosing liver diseases, and monitoring treatment efficacy. Thus, accurate measurement of these enzyme activities is …

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A-245 Development and validation of fatty acid analysis in whole blood by GC-FID

Yinghua Qiu, Laura Schurman, Andrea Božović, Vathany Kulasingam

Abstract Background Fatty acids are essential for cellular function, energy metabolism, and overall health. They serve as key components of cell membranes, energy sources, and precursors for bioactive molecules that regulate inflammation, immune responses, and cardiovascular function. Omega-3 and omega-6 fatty acids …

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B-055 Analytical Evaluation and Sigma Metrics of Next Generation Chemistry assays on the Alinity c and ARCHITECT Systems

Annie He Ren, Xiaoyan Wang, Pow Lee Cheng, Marvin Berman et autres

Abstract Background We evaluated the analytical performance of four newly developed clinical chemistry assays [Creatinine, Uric Acid, Lactate, Lactate Dehydrogenase (LDH)] on the Abbott Alinity c and ARCHITECT c8000 system. These clinical chemistry assays incorporate a multianalyte calibrator, which has extended stability. …

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