Yurie Soejima

Selective loss of Cx40 and conduction abnormalities underlie enhanced atrial fibrillation susceptibility in a HFpEF model in male mice

Kohei Kawajiri, Satoshi Iwamiya, Leo Yaga, Masahiro Yamazoe et autres

Heart failure with preserved ejection fraction (HFpEF) is frequently complicated by atrial fibrillation (AF), yet the mechanisms underlying AF vulnerability prior to or independent of extensive structural remodeling remain incompletely understood. In this study, we investigated atrial electrophysiological remodeling in a murine …

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Cytoplasmic mutant RBM20 causes arrhythmogenicity in murine atria.

Kensuke Ihara, Satoshi Iwamiya, Yurie Soejima, Yuichi Hiraoka et autres

RNA binding motif protein 20 (RBM20) is a critical splicing regulator in cardiomyocytes, and mutations in its RSRSP domain are associated with severe dilated cardiomyopathy (DCM) and a high prevalence of atrial fibrillation (AF). RBM20 mutation has long been thought to cause …

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Hypermethylation of Hif3a and Ifltd1 is associated with atrial remodeling in pressure-overload murine model

Keiko Abe, Tetsuo Sasano, Yurie Soejima, Haruhisa Fukayama et autres

Atrial remodeling is a major pathophysiological mechanism of atrial fibrillation (AF). Atrial remodeling progresses with aging and background diseases, including hypertension, heart failure, and AF itself. However, its mechanism of action and reversibility have not been completely elucidated. In this study, we …

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Hypermethylation of Hif3a and Ifltd1 Is Associated with Atrial Remodeling in Pressure- overload Murine Model

Keiko Abe, Tetsuo Sasano, Yurie Soejima, Haruhisa Fukayama et autres

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Gross Cystic Disease Fluid Protein-15 (GCDFP-15) Expression Characterizes Breast Mucinous Carcinomas in Older Women

M. Kinoshita, Motoji Sawabe, Yurie Soejima, Makiko Mieno et autres

The predominant histological subtype of breast mucinous carcinoma in older women is type B (hypercellular type), and, in younger women, it is type A (hypocellular type). The characteristics of mucinous carcinomas of the same histological subtype may differ between older and younger …

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Development of a new histological identification method of human sinoatrial node suitable for immunohistochemical study

Thavisouk Hatthakone, Sunti Oundavong, Yurie Soejima, Motoji Sawabe

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ITGB6-Knockout Suppresses Cholangiocarcinoma Cell Migration and Invasion with Declining PODXL2 Expression

Yurie Soejima, Miho Takeuchi, Nao MIYAMOTO, Motoji Sawabe et autres

Intrahepatic cholangiocarcinoma (iCCA) is a heterogeneous bile duct cancer with a poor prognosis. Integrin αvβ6 (β6) has been shown to be upregulated in iCCA and is associated with its subclassification and clinicopathological features. In the present study, two ITGB6-knockout HuCCT1 CCA cell …

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Proteome analysis demonstrates involvement of endoplasmic reticulum stress response in human myocardium with subclinical left ventricular diastolic dysfunction

Mizuho Sato, Hiroki Tsumoto, Ayumi Toba, Yurie Soejima et autres

AIM: Heart failure is increasing in Japan, in particular that with preserved ejection fraction (HFpEF) prevalent in older-aged patients. The purpose of this study was to investigate the pathophysiology during the early stage of left ventricular (LV) diastolic dysfunction by the quantitative …

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A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice

Kensuke Ihara, Tetsuo Sasano, Yuichi Hiraoka, Marina Togo‐Ohno et autres

Abstract Dilated cardiomyopathy (DCM) is a fatal heart disease characterized by left ventricular dilatation and cardiac dysfunction. Recent genetic studies on DCM have identified causative mutations in over 60 genes, including RBM20, which encodes a regulator of heart-specific splicing. DCM patients with …

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A case of β-catenin-activated hepatocellular adenoma with TERT promoter mutation in a young woman not taking oral contraceptives

Takuo Tokairin, Yohei Koshima, Hiroyuki Yoshidome, Yurie Soejima et autres

経口避妊薬の服用歴のない37才女性．健診で肝腫瘤を指摘され当施設紹介．腹部超音波検査で肝に径8 cmの結節内結節構造を呈する高エコー腫瘤を認めた．MRI-T1Wで低信号，T2Wで等信号．血管造影下CTの動脈早期相で多血性，後期相で低吸収域となり，周囲にコロナ様の濃染を認めた．肝針生検標本では異型に乏しい肝細胞から成り，免疫組織化学的にβ-catenin核内集積を認め，β-catenin活性化型肝細胞腺腫（b-HCA）と診断された．肝右葉切除術施行．切除標本には結節内結節構造を呈する径9.8 cm大の腫瘤を認め，遺伝子解析の結果，内側の結節のみにTERT promoter領域の遺伝子変異を認めた．本症例は経口避妊薬非服用女性に発生したb-HCAで，結節内結節構造の内側結節のみにTERT promoter領域の遺伝子変異が認められ，b-HCAの悪性転化を考える上で興味深い症例と思われたので報告した．

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Solute carrier transporters, reduced folate carrier 1 and equilibrative nucleoside transporter 1, as immunohistochemical markers for high-grade malignancy in bladder cancer

Tamami Denda, Shingo Kamoshida, Sadahito Kuwao, Jumpei Kawamura et autres

Clinicopathological parameters derived from initial transurethral resection of bladder tumor (TUR-Bt) have limitations in predicting tumor progression in bladder cancer. Reduced folate carrier 1 (RFC1) and equilibrative nucleoside transporter 1 (ENT1) are solute carrier (SLC) transporters supporting cellular uptake of endogenous bioactive …

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Application of cell block preparation in effusion cytology: Analysis of mismatched diagnosis and utility of immunostaining

Ayana HORIGUCHI, Takashi UMEZAWA, Miyaka Umemori, Satoshi Ito et autres

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