Kohei Kawajiri

Altered MicroRNA Signatures in Circulating Extracellular Vesicles Reflect Aortic Dilation in Takayasu Arteritis

Kohei Kawajiri, Shun Nakagama, Tetsuo Sasano, Yasuhiro Maejima

ABSTRACT Takayasu arteritis (TAK) is a large‐vessel vasculitis that can lead to aneurysmal dilation, yet reliable circulating biomarkers for vascular remodelling remain lacking. Extracellular vesicles (EVs) carry miRNAs implicated in vascular biology, but their relevance to TAK has not been fully explored. …

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Selective loss of Cx40 and conduction abnormalities underlie enhanced atrial fibrillation susceptibility in a HFpEF model in male mice

Kohei Kawajiri, Satoshi Iwamiya, Leo Yaga, Masahiro Yamazoe et autres

Heart failure with preserved ejection fraction (HFpEF) is frequently complicated by atrial fibrillation (AF), yet the mechanisms underlying AF vulnerability prior to or independent of extensive structural remodeling remain incompletely understood. In this study, we investigated atrial electrophysiological remodeling in a murine …

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Quantitative Measurement of Extracellular Vesicle‐Sized Particles in Blood Plasma by Laser Diffraction Without an Extraction Process: A Proof‐of‐Concept Study in Atrial Fibrillation

Giichi Nitta, Kotone Tatsumi, Nurjahon Ummatalieva, Suzuka Ishikawa et autres

ABSTRACT Background Extracellular vesicles (EVs) circulate in blood and may serve as disease biomarkers. However, in atrial fibrillation (AF), reliable circulating biomarkers remain limited. Conventional quantification of EVs requires cumbersome extraction procedures that can reduce quantitative accuracy. We investigated whether laser diffraction …

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Circulating Extracellular Vesicles Downregulate NOS3 Expression in Endothelial Cells in Atrial Fibrillation

Nyozin Leimon, Anna Suzuki, Kohei Kawajiri, Giichi Nitta et autres

Background: Atrial fibrillation (AF) is closely linked to endothelial dysfunction, yet its mechanisms remain unclear. Extracellular vesicles (EVs), including exosomes, are released by most cell types and mediate intercellular communication. We therefore investigated the role of EVs in endothelial dysfunction associated with …

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Fast Angular Processing For Sparse FMCW Radar Arrays With Non-uniform FFT

Gabriel Schnoering, Christian Höller, Takuya Kawaguchi, Kohei Kawajiri et autres

Among the fleet of sensors in today’s vehicles, automotive radar systems effectively provide high resolution estimations in both position and speed of targets. In addition, higher angular accuracy can be achieved by using wider radar apertures that combine efficiently multiple transmitters and …

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Gene therapy to terminate tachyarrhythmias

Kohei Kawajiri, Kensuke Ihara, Tetsuo Sasano

INTRODUCTION: To date, the treatment option for tachyarrhythmia is classified into drug therapy, catheter ablation, and implantable device therapy. However, the efficacy of the antiarrhythmic drugs is limited. Although the indication of catheter ablation is expanding, several fatal tachyarrhythmias are still refractory …

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Long-term outcome of ventricular tachycardia ablation in patients who did not undergo programmed electrical stimulation after ablation

Τakeshi Kitamura, Seiji Fukamizu, Tomoyuki Arai, Kohei Kawajiri et autres

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One-point posterior ablation for complete isolation of the posterior left atrium

Kohei Kawajiri, Seiji Fukamizu, Τakeshi Kitamura, Rintaro Hojo

The posterior wall of the left atrium (LA) plays an important role in the maintenance of atrial fibrillation (AF).1 Box isolation in addition to pulmonary vein (PV) isolation improves the outcome of persistent AF ablation.2 However, in some cases, ablation of the …

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Novel mapping algorithm during catheter ablation for ventricular parasystole originating from left anterior fascicle

Kohei Kawajiri, Τakeshi Kitamura, Rintaro Hojo, Seiji Fukamizu

A 17-year-old woman presented with frequent palpitations and shortness of breath and was diagnosed with drug-refractory ventricular parasystole. We predicted that the parasystole originated from the left anterior fascicle (LAF). Detailed activation maps of both conduction systems, including the LAF, during sinus …

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Long-term Outcome of Ventricular Tachycardia Ablation in Patients who did not Undergo Programmed Electrical Stimulation after Ablation

Τakeshi Kitamura, Seiji Fukamizu, Tomoyuki Arai, Kohei Kawajiri et autres

Background: Ventricular arrhythmia inducibility is one of the ideal endpoints of ventricular tachycardia(VT) ablation. However, it may be challenging to implement programmed electrical stimulation (PES) at the end of the procedure under several circumstances. The long-term outcome of patients who did not …

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Recurrent ischemic stroke in patients with atrial fibrillation ablation and prior stroke: A study based on etiological classification

Seiji Fukamizu, Rintaro Hojo, Τakeshi Kitamura, Iwanari Kawamura et autres

BACKGROUND: Different subtypes of ischemic stroke may have different risk factors, clinical features, and prognoses. This study investigated the incidence and mode of stroke recurrence in patients with a history of stroke who underwent atrial fibrillation (AF) ablation. METHODS: Of 825 patients …

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Two cases of paclitaxel-coated balloon angioplasty for a de-novo large coronary vessel seen with optical frequency domain imaging

Kohei Kawajiri