Aubrey Reed

Opsoclonus in Pediatric Patients: Differential Diagnosis and a Practical Approach to Evaluation

Aubrey Reed, Sarnarinder Singh Randhawa, Jason H. Peragallo, Prabhumallikarjun Patil et autres

ABSTRACT Opsoclonus is an ocular dyskinesia characterized by involuntary, arrhythmic, multidirectional saccades. In pediatrics, opsoclonus is most commonly attributed to the rare neuroinflammatory disorder opsoclonus‐myoclonus‐ataxia syndrome (OMAS), typically considered a paraneoplastic syndrome associated with neural crest tumors. However, opsoclonus can manifest as …

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Recipient plasma metabolomics as a predictor of heart transplant severe primary graft dysfunction

Joshua D. Preston, Clayton J. Rust, Aubrey Reed, Sarnarinder Singh Randhawa et autres

Primary graft dysfunction (PGD) is a leading cause of morbidity and mortality following orthotopic heart transplantation (OHT), yet its biology remains unclear, and metabolomics research is limited. A single-center study was conducted on 62 OHT recipients. Preoperative plasma samples underwent metabolomics analysis …

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Abstract 4359280: Serum Metabolomics Detects and Grades Heart Transplant Allograft Acute Cellular Rejection

Clayton J. Rust, Joshua D. Preston, Amshumanth M. Chakragiri, Jaclyn Weinberg et autres

Background: Acute cellular rejection (ACR) remains a major challenge after orthotopic heart transplantation (OHT). Surveillance relies on endomyocardial biopsy (EMB), an invasive test limited by sampling error and reader variability. Existing molecular assays can quantify transcripts or donor DNA but do not …

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Linking Ganglioside Metabolism to Immune Tolerance: Insights into Treg Biology 9258

Aubrey Reed, Julia Miranda R. Bazzano, Kirsten Baecher, Catherine Martinez et autres

Abstract Description Addressing the challenges of lifelong immunosuppression in transplant patients requires innovative approaches to achieve immune tolerance. A transcriptomic screen of kidney transplant recipients revealed higher levels of the glycosphingolipid-catabolizing protein GM2 activator protein (Gm2a) in stable patients compared to those …

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Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells

Ainsley Lockhart, Aubrey Reed, Tiago B. R. Castro, Calvin Herman et autres

The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoire of intestinal CD4+ …

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Dietary protein shapes the profile and repertoire of intestinal CD4 + T cells

Ainsley Lockhart, Aubrey Reed, Tiago B. R. Castro, Calvin Herman et autres

Abstract The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4 + T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoire of …

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TCR-Vγδ usage distinguishes protumor from antitumor intestinal γδ T cell subsets

Bernardo Sgarbi Reis, Patrick W. Darcy, Iasha Z. Khan, Christine S. Moon et autres

γδ T cells represent a substantial fraction of intestinal lymphocytes at homeostasis, but they also constitute a major lymphocyte population infiltrating colorectal cancers (CRCs); however, their temporal contribution to CRC development or progression remains unclear. Using human CRC samples and murine CRC …

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Vγ usage distinguishes pro- and anti-tumor intestinal γδ T cell subsets

Bernardo Sgarbi Reis, Patrick W. Darcy, Iasha Z. Khan, Olawale Eleso et autres

Abstract γδ T cells physiologically scan the intestinal epithelium, representing a substantial fraction of infiltrating lymphocytes in colorectal cancer (CRC), albeit their role in CRC remains unclear. Using murine CRC models, we found that most γδ T cells in pre- or non-tumor …

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Antibioitc Disk Testing v1

Aubrey Reed, Nicole Sunshine, Renae Lyons

Antibiotic Disk Testing, to check for antibiotic resistance genes

Creation of an isolate: PA and FL microbes from whole water v1

Aubrey Reed, Nicole Sunshine

Child Abusers: Can we accurately predict them by personality?

Johanna R McCormick, Kevin Miller, Emma Crissman, Aubrey Reed

Many studies label parents with certain demographic characteristics as being more prone to abuse children than others. Many predictors such as: gender, childhood abuse history, parental satisfaction, parent’s attribution style, child’s age, child disruptive behaviors, parental ethnicity, parental marital status, parental socioeconomic …