Accès ouvert
2024
article
OpenAlex
Maria Cecília Campos Canesso, Tiago B. R. Castro, Sandra Nakandakari-Higa, Ainsley A. K. Lockhart et autres
The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal antigens to CD4 + T cells and inducing their differentiation into regulatory (peripheral regulatory T cell) or inflammatory …
us
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Accès ouvert
2024
review
OpenAlex
Ainsley A. K. Lockhart, Daniel Mucida, Angelina Morand Bianchi Bilate
The intestinal epithelium, which segregates the highly stimulatory lumen from the underlying tissue, harbors one of the largest lymphocyte populations in the body, intestinal intraepithelial lymphocytes (IELs). IELs must balance tolerance, resistance, and tissue protection to maintain epithelial homeostasis and barrier integrity. …
us
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Accès ouvert
2023
article
OpenAlex
Ainsley A. K. Lockhart, Aubrey C. Reed, Tiago B. R. Castro, Calvin Herman et autres
The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoire of intestinal CD4+ …
us
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Accès ouvert
2023
conference-abstract
OpenAlex
Carla R. Nowosad, Luka Mesin, Tiago B. R. Castro, Christopher Wichmann et autres
Abstract B lymphocytes are central to maintaining balanced enteric responses through production of immunoglobulins (Igs). A large fraction of Igs are produced in germinal center (GC) responses, which form upon immunization or infection in the majority of secondary lymphoid organs, but are …
us
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Accès ouvert
2023
preprint
OpenAlex
Ainsley A. K. Lockhart, Aubrey C. Reed, Tiago B. R. Castro, Calvin Herman et autres
Abstract The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4 + T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoire of …
us
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Maria Cecília Campos Canesso, Tiago B. R. Castro, Sandra Nakandakari-Higa, Ainsley A. K. Lockhart et autres
Abstract The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Dendritic cells (DCs) orchestrate these immune responses by presenting luminal antigens and inducing functional differentiation of CD4 + T cells into regulatory (pTreg) or pro-inflammatory (Th) subsets. …
us
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Accès ouvert
2022
article
OpenAlex
Bernardo Sgarbi Reis, Patrick W. Darcy, Iasha Z. Khan, Christine S. Moon et autres
γδ T cells represent a substantial fraction of intestinal lymphocytes at homeostasis, but they also constitute a major lymphocyte population infiltrating colorectal cancers (CRCs); however, their temporal contribution to CRC development or progression remains unclear. Using human CRC samples and murine CRC …
us, br
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Accès ouvert
2022
article
OpenAlex
Ainsley A. K. Lockhart, Daniel Mucida, Roham Parsa
us
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Accès ouvert
2021
preprint
OpenAlex
Bernardo Sgarbi Reis, Patrick W. Darcy, Iasha Z. Khan, Olawale Eleso et autres
Abstract γδ T cells physiologically scan the intestinal epithelium, representing a substantial fraction of infiltrating lymphocytes in colorectal cancer (CRC), albeit their role in CRC remains unclear. Using murine CRC models, we found that most γδ T cells in pre- or non-tumor …
us, cn
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Accès ouvert
2020
article
OpenAlex
Carla R. Nowosad, Luka Mesin, Tiago B. R. Castro, Christopher Wichmann et autres
us, de
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Accès ouvert
2019
article
OpenAlex
Daria Esterházy, Maria Cecília Campos Canesso, Luka Mesin, Paul Andrew Muller et autres
us, br
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Accès ouvert
2018
article
OpenAlex
Eileen P. Scully, Monica Gandhi, Rowena Johnston, Rebecca A. Hoh et autres
Plasma human immunodeficiency virus type 1 (HIV-1) RNA levels in women are lower early in untreated HIV-1 infection compared with those in men, but women have higher T-cell activation and faster disease progression when adjusted for viral load. It is not known …
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