Jaclyn Weinberg

Anti-psychotic therapeutics modify gut microbial metabolism and modulate susceptibility to gastrointestinal infection in mice

C. Anthony Gacasan, Jaclyn Weinberg, Lyndsey Lipson, Gabrielle M Webster et autres

Abstract Antipsychotic medications are widely prescribed and associated with increased infection risk, but underlying mechanisms remain unclear. We examined if antipsychotic-induced microbiome and metabolome alterations impair colonization resistance. Using a murine model, we evaluated haloperidol, olanzapine, risperidone, and quetiapine through longitudinal microbiome …

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Metabolic reprogramming in differentiated thyroid cancer progression: a tumor metabolomics analysis

Joshua D. Preston, Logan D. Glosser, Zachery R Jarrell, Mihini S. Senanayake et autres

MSMICA: computational metabolite identification in untargeted metabolomics by integrating MS, retention time, and biological evidence

Jiada Zhan, Jaclyn Weinberg, William J. Crandall, Zhaohui Qin et autres

Abstract Mass Spectrometry Metabolomics Identification Connection Algorithm (MSMICA) is an algorithm for automated metabolite identification in untargeted liquid chromatography-high-resolution mass spectrometry (LC-HRMS) analyses. Limitations in metabolite identification can occur due to the availability and cost of standards and prevent recognition of metabolic …

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Microbiome-associated metabolites, valerobetaine and homocarnitine, inhibit carnitine transport via OCTN2

Jaclyn Weinberg, Jennifer Jeon, William J. Crandall, Choon‐Myung Lee et autres

This study uses transport physiology, ectopic gene expression, and mass spectrometry-based detection methods to show that the microbiome-derived valerobetaine and its mammalian metabolic product, homocarnitine, are transported by OCTN2, an important carnitine transporter. Moreover, both valerobetaine and homocarnitine inhibit carnitine transport, providing …

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Enzymes define pathways and metabolic relationships

Jiada Zhan, Zachery Jarrell, Melissa L. Kemp, Jaclyn Weinberg et autres

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Structural Diversity and Analytical Characterization of Acylhomocarnitines

Jaclyn Weinberg, William J. Crandall, Zachery Jarrell, Gahyun Lim et autres

High Resolution Image Download MS PowerPoint Slide Homocarnitine is a five-carbon analog of carnitine produced in mammals through hydroxylation of the microbiome-derived metabolite δ-valerobetaine. Here, we describe liquid chromatography–mass spectrometry methods for the measurement of fatty acyl-homocarnitines, a previously uncharacterized family of …

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High-Throughput Generation of Drug Metabolite Reference Materials for Analytic Support of Precision Pharmacology (Abstract ID: 225442)

Jaclyn Weinberg, Zachery R Jarrell, Choon‐Myung Lee, Ho Young Lee et autres

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Recipient plasma metabolomics as a predictor of heart transplant severe primary graft dysfunction

Joshua D. Preston, Clayton J. Rust, Aubrey Reed, Sarnarinder Singh Randhawa et autres

Primary graft dysfunction (PGD) is a leading cause of morbidity and mortality following orthotopic heart transplantation (OHT), yet its biology remains unclear, and metabolomics research is limited. A single-center study was conducted on 62 OHT recipients. Preoperative plasma samples underwent metabolomics analysis …

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Abstract 4359280: Serum Metabolomics Detects and Grades Heart Transplant Allograft Acute Cellular Rejection

Clayton J. Rust, Joshua D. Preston, Amshumanth M. Chakragiri, Jaclyn Weinberg et autres

Background: Acute cellular rejection (ACR) remains a major challenge after orthotopic heart transplantation (OHT). Surveillance relies on endomyocardial biopsy (EMB), an invasive test limited by sampling error and reader variability. Existing molecular assays can quantify transcripts or donor DNA but do not …

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Pharmaceutical Metabolite Data Base, PharmMet DB: Reference data base for drug metabolites generated by human liver S9 fraction

Jennifer Jeon, Zachery Jarrell, Choon‐Myung Lee, Grant Singer et autres

Drug monitoring is an essential component of precision therapeutics, yet existing data bases to support therapeutic monitoring are limited to data curated from the scientific literature or predicted in silico. We used human liver S9 fraction to generate metabolites from 1114 therapeutic …

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Analysis of host and gut microbial biotransformation products of kratom (Mitragyna speciosa) by mass spectrometry

William J. Crandall, Ken Liu, Choon M. Lee, Grant Singer et autres

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Enzymes define pathways and metabolic relationships

Jiada Zhan, Zachery Jarrell, Melissa L. Kemp, Jaclyn Weinberg et autres

Abstract Gene-centric pathway mapping tools, widely used to interpret untargeted liquid chromatography mass spectrometry (LC-MS) metabolomics data, may underperform because a single metabolite can generate multiple spectral features, inflating false positive rates. Classic enzymology, which established metabolite flow before gene sequencing, offers …

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