Yoshihiro Fujimura

Quality of platelet concentrates after three‐day storage following 265 nm ultraviolet C ‐light‐emitting diode irradiation

Tomoya Hayashi, Yoshihiko Sakurai, Yoshihiro Fujimura, Kumiko Oguma et autres

OBJECTIVES: We aimed to investigate the quality of platelets after storage following irradiation with ultraviolet C (UVC) light-emitting diodes (LED). BACKGROUND: Controlling transfusion-related infections, particularly bacterial contamination of platelet concentrates (PCs), is urgently required. UVC-LEDs have attracted considerable attention as potential solutions …

jp (code pays fourni par la source)

Irradiation with 265-nm Ultraviolet Light-Emitting Diodes to Plasma: Alterations of Hemostatic Parameters and von Willebrand Factor

Tomoya Hayashi, Yoshihiro Fujimura, Yoshihiko Sakurai, Mikako Masaki et autres

Introduction: Among pathogen inactivation methods for blood products, an ultraviolet C (UVC) irradiation has been attracting attention. We previously reported that 265 nm UV-LED (UVC-LED) effectively prevents bacterial infection. However, the effect of UVC-LED on plasma was not considered. This study aimed …

jp (code pays fourni par la source)

A NOVEL HAEMODILUTION CHIP MOUNTED ON THE TOTAL THROMBUS-FORMATION ANALYSIS SYSTEM, A FLOW CHAMBER SYSTEM, ENABLES STABLE ANALYSIS OF PLATELET PRODUCTS UNDER LOW PLATELET CONCENTRATION/HIGH SHEAR CONDITIONS

Akihiro Fuchizaki, Kazuta Yasui, Tomoya Hayashi, Mitsunobu Tanaka et autres

【背景と目的】血栓形成能解析システム（Total Thrombus-formation Analysis System：T-TAS）は，再構成血液サンプルを用いることで血小板製剤の止血への寄与を定量的に解析することが可能である．しかしながら，血小板数が少ない検体には不向きである．我々はチャンバーの深さが浅い血液希釈（haemodilution：HD）チップを導入することで，低血小板検体への適応と高せん断応力条件（1,500s－1）による止血能評価システムの開発を試みた．

jp (code pays fourni par la source)

QUANTIFICATION OF THE CONTRIBUTION OF INDIVIDUAL COAGULATION FACTORS TO HAEMOSTASIS USING A MICROCHIP FLOW CHAMBER SYSTEM AND RECONSTITUTED BLOOD FROM DEFICIENT PLASMA

Akihiro Fuchizaki, Kazuta Yasui, Tomoya Hayashi, Yoshihiro Fujimura et autres

【背景と目的】個々の凝固因子の止血への寄与を定量化することは稀な凝固因子欠乏症患者の止血機能の理解と適切な治療法の探索に役立つ可能性がある．

jp (code pays fourni par la source)

FROM "HERETIC" TO "LUCKY ADVENTURER" IN THE BLOOD TRANSFUSION DEPARTMENT

Yoshihiro Fujimura

jp (code pays fourni par la source)

Quantification of the contribution of individual coagulation factors to haemostasis using a microchip flow chamber system and reconstituted blood from deficient plasma

Akihiro Fuchizaki, Kazuta Yasui, Tomoya Hayashi, Yoshihiro Fujimura et autres

Abstract Background and Objectives Quantifying the contribution of individual coagulation factors to haemostasis may aid our understanding of the haemostatic function in patients with rare coagulation deficiencies (RCDs) and the exploration of suitable treatments. Materials and Methods Reconstituted blood prepared from specific …

jp (code pays fourni par la source)

A novel haemodilution chip mounted on the total thrombus‐formation analysis system, a flow chamber system, enables stable analysis of platelet products under low platelet concentration/high shear conditions

Akihiro Fuchizaki, Kazuta Yasui, Tomoya Hayashi, Mitsunobu Tanaka et autres

Abstract Background and Objectives The total thrombus‐formation analysis system (T‐TAS) can quantitatively analyse the contribution of platelets to haemostasis using reconstituted blood samples. However, it is unsuitable in cases with low platelet counts. We introduced a haemodilution (HD) chip with a shallow …

jp (code pays fourni par la source)

Hereditary TTP/Upshaw–Schulman syndrome: the ductus arteriosus controls newborn survival

Yoshihiro Fujimura

jp (code pays fourni par la source)

PB0318 Evaluation of a Novel ADAMTS13 Activity Reagent Using Fully Automated Analyzer

M. Kubo, Karoliina Könkö, Emiko Kinoshita, Satoshi Uemae et autres

Background: ADAMTS13 activity testing is pivotal to confirm the diagnosis of thrombotic thrombocytopenic purpura (TTP) and guide optimal management during both the acute and remission phase.The HemosIL Acustar ADAMTS13 Activity Assay (Werfen), a rapid fully-automated ADAMTS13 activity assay, has been recently released …

it, jp (code pays fourni par la source)

Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) in Japan 2023

Masanori Matsumoto, Yoshitaka Miyakawa, Koichi Kokame, Yasunori Ueda et autres

Thrombotic thrombocytopenic purpura (TTP) can rapidly become a life-threatening condition, and the importance of its appropriate diagnosis and treatment cannot be overstated. Until recently, TTP has mainly been diagnosed by clinical findings such as thrombocytopenia and hemolytic anemia. In addition to these …

jp (code pays fourni par la source)

A NOVEL QUANTITATIVE METHOD TO EVALUATE THE CONTRIBUTION OF PLATELET PRODUCTS TO WHITE THROMBUS FORMATION IN RECONSTITUTED BLOOD UNDER FLOW CONDITIONS

Akihiro Fuchizaki, Kazuta Yasui, Tomoya Hayashi, Mitsunobu Tanaka et autres

【背景と目的】現在，血小板（Platelet：PLT）製剤の品質評価は，検査材料としてのPLTのみを分析する一連のin vitro試験で行われている．しかしながら，連続的な止血過程に近い条件下でPLT生理機能を評価することが理想的である．そこで本研究では，マイクロチャンバーを用いて，一定のせん断応力（600/s），赤血球（Red blood cell：RBC）および血漿の存在下，PLT製剤の血栓形成能を評価するin vitroシステムの開発を試みた．

jp (code pays fourni par la source)

COLLABORATION BETWEEN A UNIVERSITY MEDICAL SCHOOL AND A REGIONAL JAPANESE RED CROSS BLOOD CENTER TO TRAIN MEDICAL STUDENTS IN BLOOD TRANSFUSION EDUCATION/PRACTICE AND CLINICAL RESIDENTS IN BLOOD DONATION OPERATIONS

Akira Yoshioka, Yoshihiko Sakurai, Hiroko Shima, Satohiro Nakagawa et autres

血液事業は日本赤十字社が担当する国家的な重要医療インフラの一つであるが，一般的に医師の血液事業に対する認識は表面的理解にとどまることが多い．また，本事業においては，安全で良質な血液の確保に関わる献血健診医の役割は大きいが，血液センター専任医師と献血健診医師は質量ともに不足状態が続いている．我々が実施している「奈良方式」は，奈良県立医科大学医学科学生への卒前教育としての附属病院輸血部における“教育・実習（14時間）”と奈良県赤十字血液センターにおける“献血ドナー体験を含む実習（3時間）”，および同附属病院臨床研修医への卒後研修としての奈良センターでの1週間の“On-the-Job Trainingによる献血業務研修”で構成されている．健診医師数を中心にその成果について検討したところ，奈良方式履修医師の献血健診への貢献が明らかになった．血液センターにとっては業務上負担感のある医学生と研修医への実習と研修であるが，これらを積極的，継続的に実施する「奈良方式」は，医師の血液事業に対する認識を深めるとともに，血液事業に資する献血健診医の育成と確保に有効かつ効果的に機能するものと考える．

jp, us (code pays fourni par la source)