Quality of platelet concentrates after three‐day storage following 265 nm ultraviolet C ‐light‐emitting diode irradiation
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Le résumé fourni par la source
OBJECTIVES: We aimed to investigate the quality of platelets after storage following irradiation with ultraviolet C (UVC) light-emitting diodes (LED). BACKGROUND: Controlling transfusion-related infections, particularly bacterial contamination of platelet concentrates (PCs), is urgently required. UVC-LEDs have attracted considerable attention as potential solutions to this problem. METHODS: PCs (5.5 mL) were irradiated with 265 nm UVC-LED for up to 60 min and then stored at 22°C with shaking for 3 days. PC quality parameters, such as platelet count, biochemical profiles, including electrolytes and metabolism, activation markers and platelet aggregability, were analysed before and after storage. Prior to the storage study, to validate the appropriateness of the UVC-LED dose used, the PCs were inoculated with Staphylococcus aureus or Bacillus cereus, and their colony-forming ability was evaluated after irradiation with the same dose of UVC-LED. RESULTS: , reaching approximately 80% of the level in the control without irradiation, but no further decrease was recorded after storage. The biochemical profiles and activation markers showed little alterations. CONCLUSION: These results indicate that UVC-irradiated platelets maintain sufficient quality for practical use even after storage. Although this was a bench-scale study, our findings suggest that irradiation of PCs with 265 nm UVC-LED may enhance the safety of blood transfusions while preserving their efficacy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Quality of platelet concentrates after three‐day storage following 265 nm ultraviolet <scp>C</scp> ‐light‐emitting diode irradiation
- Date Crossref
- 09/10/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Japanese Red Cross Society pays non établi dans la noticeOrganisation à but non lucratif
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Japanese Red Cross Narita Hospital pays non établi dans la noticeÉtablissement de santé
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Tokyo City University pays non établi dans la noticeUniversité ou école supérieure
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The University of Tokyo Department of Urban Engineering pays non établi dans la noticeUniversité ou école supérieure
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Department of Research and Development pays non établi dans la noticeInstitution
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Japanese Red Cross Nara Blood Center Nara Japan pays non établi dans la noticeInstitution
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Japanese Red Cross Osaka Blood Center Osaka Japan pays non établi dans la noticeInstitution
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Central Blood Institute Japanese Red Cross Society pays non établi dans la noticeStructure de recherche
Japanese Red Cross Society, Japanese Red Cross Narita Hospital et Tokyo City University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.