María del Mar Pozo‐Balado

Thymosin-α-1 plasma levels measured after acute SARS-CoV-2 infection are associated with the severity of infection

Israel Olivas‐Martínez, Miguel Genebat, Ángel Bulnes‐Ramos, Vanesa Garrido‐Rodríguez et autres

Abstract Thymalfasin, the synthetic form of Thymosin-α-1 (Tα1), which is a thymic peptide hormone with immunomodulatory properties, has been used in the treatment of severe cases of COVID-19, with inconclusive results. Plasma concentrations of Tα1 in COVID-19 patients have never been measured, …

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Unveiling altered CD8 T-cell metabolism and homeostatic proliferation behind a low CD4/CD8 ratio in ART-suppressed HIV individuals with normal CD4 recovery

Vanesa Garrido‐Rodríguez, Ángel Bulnes‐Ramos, Israel Olivas-Martínez, María del Mar Pozo‐Balado et autres

Background People living with chronic HIV (PLWH) show immune dysfunction, despite viral suppression and normal CD4 recovery, particularly those with low CD4/CD8 ratios. Subjacent cellular alterations of such a reliable marker of clinical progression remain elusive. Methods Categorization by CD4/CD8 ratio after …

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The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function

Vanesa Garrido‐Rodríguez, Ángel Bulnes‐Ramos, Israel Olivas‐Martínez, María del Mar Pozo‐Balado et autres

BACKGROUND: Persistence of a low CD4/CD8 ratio is associated with an increased morbimortality in people living with HIV (PLWH) under effective antiretroviral therapy. We aimed to explore the immunological significance of a persistently low CD4/CD8 ratio, even despite normal CD4 levels, and …

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Higher plasma levels of thymosin-α1 are associated with a lower waning of humoral response after COVID-19 vaccination: an eight months follow-up study in a nursing home

María del Mar Pozo‐Balado, Ángel Bulnes‐Ramos, Israel Olivas‐Martínez, Vanesa Garrido‐Rodríguez et autres

BACKGROUND: Older people achieve lower levels of antibody titers than younger populations after Covid-19 vaccination and show a marked waning humoral immunity over time, likely due to the senescence of the immune system. Nevertheless, age-related predictive factors of the waning humoral immune …

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Longitudinal age differences in humoral responses to the COVID-19 vaccine in the elderly are lost after the third dose

María del Mar Pozo‐Balado, Ángel Bulnes‐Ramos, Vanesa Garrido‐Rodríguez, Israel Olivas-Martínez et autres

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Dysregulation of iron metabolism modulators in virologically suppressed HIV-infected patients

Vanesa Garrido‐Rodríguez, Ana Isabel Álvarez‐Ríos, Israel Olivas‐Martínez, María del Mar Pozo‐Balado et autres

Background Iron metabolism plays an essential role in cellular functions. Since virologically suppressed chronic HIV-infected subjects under effective antiretroviral treatment (ART) exhibit a persistent immune dysfunction that leads to comorbidities, iron homeostasis may be relevant in this context. We aimed to explore …

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Partial restoration of gut‐mucosal dysbiosis in late‐treated HIV‐infected subjects with CD4 T‐cell recovery

Israel Olivas‐Martínez, Isaac Rosado‐Sánchez, Juan Antonio Cordero Varela, Salvador Sobrino et autres

Partial restoration of

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Mejoría de la función cardio-respiratoria en paciente con circulación de fontán tras la intervención quirúrgica de su escoliosis

Estefanía Chamorro, María del Mar Pozo‐Balado

espanolLa escoliosis puede tener un impacto negativo sobre la funcion cardiorespiratoria en pacientes con cirugia de Fontan. Cuando las consecuencias de la progresion de la deformidad sobre la calidad de vida y la supervivencia potencial a largo plazo del paciente superan los …

Reliability and Validity of the Adapted Spanish Version of the Early-onset Scoliosis-24 Questionnaire

María del Mar Pozo‐Balado, Hiroko Matsumoto, Michael G. Vitale, Juan Manuel Praena‐Fernández et autres

STUDY DESIGN: Translation and validation of the Early Onset Scoliosis-24 Questionnaire (EOSQ-24). OBJECTIVE: To cross-culturally adapt the American English version of the EOSQ-24 into Spanish language, and to assess its reliability and discriminative validity. SUMMARY OF BACKGROUND DATA: Treatment of early-onset scoliosis …

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Detectable Viral Load Aggravates Immunosenescence Features of CD8 T-Cell Subsets in Vertically HIV-Infected Children

Laura Díaz, Gema Méndez‐Lagares, Rafael Correa‐Rocha, Yolanda M. Pacheco et autres

BACKGROUND: CD8 T cells are crucial in the immune responses against HIV infection, but HIV-infected adults suffer a naive CD8 T-cell depletion and accelerated senescence caused by chronic antigen stimulation. Although HIV-infected children preserve a better immune reconstitution capacity their CD8 responses …

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Differential alterations of the CD4 and CD8 T cell subsets in HIV-infected patients on highly active antiretroviral therapy with low CD4 T cell restoration

Gema Méndez‐Lagares, Antonio García‐Pergañeda, María del Mar Pozo‐Balado, Miguel Genebat et autres

OBJECTIVES: This study examined the homeostatic parameters possibly related to HIV-infected patients who, despite being under suppressive highly active antiretroviral therapy (HAART), show low-level CD4 T cell repopulation (LLR). METHODS: Twenty-one LLR individuals, 20 HIV-infected controls with satisfactory CD4 T cell repopulation …

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CD4+CD25+/hiCD127loPhenotype Does Not Accurately Identify Regulatory T Cells in All Populations of HIV‐Infected Persons

María del Mar Pozo‐Balado, Manuel Leal, Gema Méndez‐Lagares, Yolanda M. Pacheco

The most commonly used regulatory T cell (Treg) phenotypes, CD4(+)CD25(hi)CD127(lo) and CD4(+)CD25(hi)FoxP3(+), were simultaneously used to determine the Treg frequency in 2 different groups of human immunodeficiency virus (HIV)-infected persons, one viremic and other aviremic. As expected, a strong correlation between both …

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