Ildikó Dobos

Anti-CGRP antibody galcanezumab modifies the function of the trigeminovascular nocisensor complex in the rat

Nadine Friedrich, Krisztína Németh, Martin Tanner, Judit Rosta et autres

BACKGROUND: Monoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide (CGRP) are effective in the prevention of chronic and frequent episodic migraine. Since the antibodies do not cross the blood brain barrier, their antinociceptive effect is attributed to effects in meningeal tissues. …

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Longitudinal Study of Functional Reinnervation of the Denervated Skin by Collateral Sprouting of Peptidergic Nociceptive Nerves Utilizing Laser Doppler Imaging

Szandra Lakatos, Gábor Jancsó, Ágnes Horváth, Ildikó Dobos et autres

Restitution of cutaneous sensory function is accomplished by neural regenerative processes of distinct mechanisms following peripheral nerve lesions. Although methods available for the study of functional cutaneous nerve regeneration are specific and accurate, they are unsuitable for the longitudinal follow-up of the …

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Role of Gangliosides in Peripheral Pain Mechanisms

Péter Sántha, Ildikó Dobos, Gyöngyi Kis, Gábor Jancsó

Gangliosides are abundantly occurring sialylated glycosphingolipids serving diverse functions in the nervous system. Membrane-localized gangliosides are important components of lipid microdomains (rafts) which determine the distribution of and the interaction among specific membrane proteins. Different classes of gangliosides are expressed in nociceptive …

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Insulin Confers Differing Effects on Neurite Outgrowth in Separate Populations of Cultured Dorsal Root Ganglion Neurons: The Role of the Insulin Receptor

Bence András Lázár, Gábor Jancsó, Laura Pálvölgyi, Ildikó Dobos et autres

Apart from its pivotal role in the regulation of carbohydrate metabolism, insulin exerts important neurotrophic and neuromodulator effects on dorsal root ganglion (DRG) neurons. The neurite outgrowth-promoting effect is one of the salient features of insulin’s action on cultured DRG neurons. Although …

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Experimental Modelling of Spinal Anaesthesia in Rats

Ildikó Dobos

SUMMARY Experiment I Many previous studies suggest that the correct location of the catheter tip is crucial concerning the effect obtained. However, the previous studies did not suggest a reliable method for the prediction of the location of the catheter tip before …

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Inhibition of glucosylceramide synthase reversibly decreases the capsaicin-induced activation and TRPV1 expression of cultured dorsal root ganglion neurons

Péter Sántha, Orsolya Oszlács, Mária Dux, Ildikó Dobos et autres

Recent studies have demonstrated significant changes in the neuronal ganglioside status associated with altered functional states of nociceptive primary sensory neurons. In the present study, therefore, the effects of the inhibition of glucosylceramide synthase, the key enzyme of ganglioside synthesis, were studied …

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Long-Term Changes in the Antinociceptive Potency of Morphine or Dexmedetomidine After a Single Treatment

Gyöngyi Horváth, Gabriella Kékesi, Ildikó Dobos, Walter Klimscha et autres

In Brief Acute tolerance develops after a single administration of opiate or α2-adrenergic agonists, but the characteristics of the delayed type of acute tolerance have not been analyzed in acute and inflammatory thermal pain tests. We investigated the long-term changes in the …

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The Antinociceptive Potencies and Interactions of Endogenous Ligands During Continuous Intrathecal Administration: Adenosine, Agmatine, and Endomorphin-1

Gabriella Kékesi, Ildikó Dobos, Gy rgy Benedek, Gy ngyi Horvath

UNLABELLED: Recently, a series of endogenous ligands related to inhibition of sensory transduction of noxious stimuli at the spinal level has been described, including endomorphins, agmatine, and adenosine, which act on different receptors; however, little data exist concerning their effect during continuous …

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Antinociceptive activity of Sempervivum tectorum L. extract in rats

Gabriella Kékesi, Ildikó Dobos, György Benedek, Gyöngyi Horváth

The extract of Sempervivum tectorum L. (Crassulaceae) containing several flavonoids is widely used as an antiinflammatory agent in folk medicine. Previous studies have demonstrated that various flavonoids or flavonoid-containing plant extracts produce significant antinociception, but no data are available concerning their antinociceptive …

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Evaluation of endomorphin-1 on the activity of Na+,K+-ATPase using in vitro and in vivo studies

Gyöngyi Horváth, Ahmad Agil, Gabriella Joó, Ildikó Dobos et autres

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The antinociceptive effect of intrathecal kynurenic acid and its interaction with endomorphin-1 in rats

Gabriella Kékesi, Gabriella Joó, Emese Csüllög, Ildikó Dobos et autres

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The Synergistic Antinociceptive Interactions of Endomorphin-1 with Dexmedetomidine and/or S(+)-Ketamine in Rats

Gyöngyi Horváth, Gabriella Joó, Ildikó Dobos, Walter Klimscha et autres

UNLABELLED: Spinal administration of the endogenous mu-opioid agonist peptide, endomorphin-1, results in antinociception in rodents, but there are few data about its interaction with other antinociceptive drugs. We investigated the antinociceptive interactions at the spinal level of endomorphin-1 with the N-methyl-D-aspartate antagonist …

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