Nadine Friedrich

Evaluation of AI Chatbot Responses to Pediatric Urology Frequently Asked Questions

Najva Mazhari, Andrew Freedman, Nadine Friedrich, Timothy Daskivich et autres

OBJECTIVE: To evaluate the quality of responses from 4 publicly available LLMs (ChatGPT-4o, Claude 3.7, Gemini 2.5, and Copilot) to frequently asked questions (FAQs) in pediatric urology. METHODS: FAQs were generated using standardized prompts and submitted to each LLM using parent-centered instructions. …

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Efficacy of a stepped-care approach for school-age children with mild to moderate ADHD (ESCAschool-moderate): an adaptive intervention study including a randomized controlled trial

Manfred Döpfner, Christina Dose, Christopher Hautmann, Martin Hellmich et autres

BACKGROUND: This German multicenter study aimed to analyze the efficacy of telephone-assisted self-help (TASH) and changes during subsequent adaptive treatment in children with mild-to-moderate ADHD. METHODS: Participants were children (6;0-11;11 years) with mild-to-moderate ADHD. Study Step 1 comprised a randomized waitlist-controlled trial …

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Machine learning approach for prediction of immune-related pneumonitis.

Barliz Waissengrin, Yasaman Fatapour, Jose Acitores, RamaChandra Das et autres

12153 Background: Immune-related adverse events (irAE) associated with immune checkpoint inhibitors (ICI) substantially contribute to treatment-related morbidity, yet reliable pretreatment predictors remain unavailable. Immune-related pneumonitis (irP) is among the most serious irAE and is associated with a significant risk for mortality. Machine …

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IP80-08 ACCURACY OF CANCER MORTALITY RISK ESTIMATES IN PROSTATE CANCER CONSULTATIONS

Jasmine S. Lin, Michael Luu, Nadine Friedrich, Renning Zheng et autres

IP80-20 EVALUATING LINGUISTIC COMPLEXITY OF PHYSICIAN COMMUNICATION IN PROSTATE CANCER CONSULTATIONS

Jasmine S. Lin, Michael Luu, Nadine Friedrich, Renning Zheng et autres

IP61-16 ACCURACY OF LIFE EXPECTANCY ESTIMATES IN PROSTATE CANCER CONSULTATIONS

Jasmine S. Lin, Michael Luu, Nadine Friedrich, Renning Zheng et autres

Evaluation of AI Chatbot Responses to Pediatric Urology Frequently Asked Questions

Paul Kokorowski, Andrew Freedman, Nadine Friedrich, Timothy Daskivich et autres

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Effect of anti-CGRP antibody galcanezumab on neuropeptide-mediated trigeminovascular function in rats

Nadine Friedrich

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Anti-CGRP antibody galcanezumab modifies the function of the trigeminovascular nocisensor complex in the rat

Nadine Friedrich, Krisztína Németh, Martin Tanner, Judit Rosta et autres

BACKGROUND: Monoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide (CGRP) are effective in the prevention of chronic and frequent episodic migraine. Since the antibodies do not cross the blood brain barrier, their antinociceptive effect is attributed to effects in meningeal tissues. …

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Semi-Automated Recording of Facial Sensitivity in Rat Demonstrates Antinociceptive Effects of the Anti-CGRP Antibody Fremanezumab

Nicola Benedicter, Karl Meßlinger, Birgit Vogler, Kimberly D. Mackenzie et autres

Migraine pain is frequently accompanied by cranial hyperalgesia and allodynia. Calcitonin gene-related peptide (CGRP) is implicated in migraine pathophysiology but its role in facial hypersensitivity is not entirely clear. In this study, we investigated if the anti-CGRP monoclonal antibody fremanezumab, which is …

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Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system

Judit Rosta, Máté Tóth, Nadine Friedrich, Péter Sántha et autres

BACKGROUND: Clinical observations suggest that hyperinsulinemia and insulin resistance can be associated with migraine headache. In the present study we examined the effect of insulin on transient receptor potential vanilloid 1 (TRPV1) receptor-dependent meningeal nociceptor functions in rats. METHODS: The effects of …

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