Anna-Lisa Vocaturo

Nanoparticles targeting liver sinusoidal endothelial cells improve tolerance to vector and transgene antigens through tolerance spreading

Romain Hardet, Shu-Hung Wang, Sandrine Delignat, Marine Blandin et autres

Liver sinusoidal endothelial cells (LSECs) naturally cross-present antigens and induce T cell tolerance. Targeting LSECs with peptide-coupled nanoparticles offers an efficient strategy to induce antigen-specific immune tolerance. Previous preclinical and clinical studies have shown that peptide-coupled nanoparticles can effectively inhibit T cell …

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Nanoparticle platform preferentially targeting liver sinusoidal endothelial cells induces tolerance in CD4+ T cell-mediated disease models

Shu-Hung Wang, Isabelle Serr, Reinaldo G. Digigow, Barbara Metzler et autres

Introduction: Treating autoimmune diseases without nonspecific immunosuppression remains challenging. To prevent or treat these conditions through targeted immunotherapy, we developed a clinical-stage nanoparticle platform that leverages the tolerogenic capacity of liver sinusoidal endothelial cells (LSECs) to restore antigen-specific immune tolerance. Methods: T …

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Role of Hyaluronic Acid in thein vivoAggregation of Cartilage Proteoglycans

Giuliano Quintarelli, Anna-Lisa Vocaturo, Lennart Rodén, MARINELLA BELLOCCI et autres

From studies of isolated cartilage proteoglycans in solution it has been inferred that they occur in the tissue as aggregates of high molecular weight which consist of proteoglycan monomers, hyaluronic acid and specific link proteins. The present investigation provides direct evidence for …

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The effects of acetylation on the binding region of cartilage proteoglycans to hyaluronic acid

Giuliano Quintarelli, Anna-Lisa Vocaturo, Rosa Eliza Zito, Lennart Rodén

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Preliminary ultrastructural demonstration of hyaluronic acid‐proteoglycan interaction in cartilage matrix

Giuliano Quintarelli, Anna-Lisa Vocaturo, MARINELLA BELLOCCI, Lennart Rodén et autres

Abstract Recent chemical studies have indicated that the chondroitin sulfate proteoglycan of cartilage interacts with hyaluronic acid to form high molecular weight aggregates. In the present study, morphological evidence has been obtained that this interaction represents a physiologically occurring phenomenon, as indicated …

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