Accès ouvert
2026
article
OpenAlex
Romain Hardet, Shu-Hung Wang, Sandrine Delignat, Marine Blandin et autres
Liver sinusoidal endothelial cells (LSECs) naturally cross-present antigens and induce T cell tolerance. Targeting LSECs with peptide-coupled nanoparticles offers an efficient strategy to induce antigen-specific immune tolerance. Previous preclinical and clinical studies have shown that peptide-coupled nanoparticles can effectively inhibit T cell …
fr, de, us
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Accès ouvert
2025
article
OpenAlex
Anne-Marinette Cao, Jules Duruz, Mauro Sousa de Almeida, Dimitri Vanhecke et autres
Abstract Iron is an essential element for numerous physiological processes in the human body, and maintaining proper iron homeostasis is critical for health. Iron imbalance can lead to conditions like iron deficiency anemia (IDA). Intravenous (IV) iron drugs, including iron-carbohydrate complexes such …
ch
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Accès ouvert
2025
article
OpenAlex
Mauro Sousa de Almeida, Amélie Bazzoni, Sandor Balog, Kata Dorbić et autres
Intravenous iron drugs are commonly used in the treatment of iron deficiency/iron deficiency anaemia. However, the cellular mechanisms underlying the uptake of these complexes remain poorly understood. This study examines the interaction of two iron complexes, iron sucrose and ferric-carboxymaltose, with murine …
ch
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Accès ouvert
2025
article
OpenAlex
Stephanie Eitner, Vera M. Kissling, Alexandra Rippl, Leonard Krupnik et autres
Iron-carbohydrate complexes (ICCs) are widely used nanomedicines to treat iron deficiency anemia, yet their intracellular fate and the mechanisms of action underlying their differences in treatment outcomes remain poorly understood. Here, we thus performed a comprehensive dynamic characterization of two structurally distinct …
ch
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Accès ouvert
2025
article
OpenAlex
Amy Barton Pai, Zhoumeng Lin, Heather H. Gustafson, Beat Flühmann et autres
Intravenous iron-carbohydrate complexes are a class of nanomedicines that are widely used globally to treat iron deficiency and iron deficiency anemia associated with a wide spectrum of disease states. Despite being widely used in clinical practice for more than seven decades, the …
ch, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Dario Didona, Christoph Hudemann, Holger Garn, Daria Krzikalla et autres
BACKGROUND: Pemphigus vulgaris (PV) is a CD4+ T-cell-dependent autoantibody-mediated blistering disease associated with human leucocyte antigen (HLA) class II molecules. IgG autoantibodies against the primary autoantigen desmoglein 3 (Dsg3), a desmosomal adhesion protein on epidermal keratinocytes, cause loss of epidermal cell adhesion. …
de, us, nl, it, gb
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Accès ouvert
2025
article
OpenAlex
Ali Akyol, Şeyma Çimen, Benjamin Gottschalk, Yusuf C. Erdoğan et autres
High Resolution Image Download MS PowerPoint Slide Here, we developed IronFist, a genetically encoded fluorescent reporter that enables dynamic tracking of labile ferrous ions (Fe 2+ ) in live cells. IronFist is a bicistronic system combining the iron-sensitive hemerythrin-like (Hr) domain from …
at, tr, fr, mx, us, ch
(code pays fourni par la source)
2025
preprint
OpenAlex
Stephanie Eitner, Vera M. Kissling, Alexandra Rippl, Leonard Krupnik et autres
Abstract Iron-carbohydrate complexes (ICCs) are widely used nanomedicines to treat iron deficiency anemia, yet their intracellular fate and the mechanisms of action underlying their differences in treatment outcomes remain poorly understood. Here, we thus performed a comprehensive dynamic characterization of two structurally …
ch, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Shu-Hung Wang, Isabelle Serr, Reinaldo Digigow, Barbara Metzler et autres
Introduction: Treating autoimmune diseases without nonspecific immunosuppression remains challenging. To prevent or treat these conditions through targeted immunotherapy, we developed a clinical-stage nanoparticle platform that leverages the tolerogenic capacity of liver sinusoidal endothelial cells (LSECs) to restore antigen-specific immune tolerance. Methods: T …
us, de
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Ali Akyol, Şeyma Çimen, Benjamin Gottschalk, Amy Barton Pai et autres
Abstract Any disturbances in cellular iron regulation can lead to dysfunctions and various diseases. However, our current understanding of iron dynamics in living cells is hampered by the lack of high-resolution iron reporter systems capable of monitoring the iron status of individual …
at, tr, us, ch
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2025
conference-paper
OpenAlex
Cornelia Gottwick, Pia Averhoff, Daria Krzikalla, Reinaldo Digigow et autres
Background Liver sinusoidal endothelial cells (LSECs) are major inducers of immune tolerance. Previously, we have shown that targeting of autoantigen peptides to LSECs using nanoparticles (NP) can be used for therapy of autoimmune diseases. In liver fibrosis, LSECs capillarize and are believed …
de
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Accès ouvert
2024
article
OpenAlex
Niusha Nikravesh, Alexandra Rippl, Tobias Hoch, Stephanie Eitner et autres
The first exposure of intravenously (IV) administered nanomedicines in vivo is to endothelial cells (ECs) lining blood vessels. While it is known that in vitro endothelium models to assess responses to circulating nanoparticles require shear stress, there is no consensus on when …
ch
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