Elena Toledano‐Macías

Effect of Combination of Blue and Red Light with Terbinafine on Cell Viability and Reactive Oxygen Species in Human Keratinocytes: Potential Implications for Cutaneous Mycosis

Luis Alfonso Pérez-González, María Antonia Martínez‐Pascual, Elena Toledano‐Macías, Rosa Cristina Jara-Laguna et autres

Cutaneous mycoses are common infections whose treatment has become more complex due to increasing antifungal resistance and the need for prolonged therapies, hindering patient adherence and increasing the incidence of adverse effects. Consequently, the use of physical therapies, especially photodynamic therapy (PDT), …

es (code pays fourni par la source)

Electric Stimulation at 448 kHz Modulates Proliferation and Differentiation of Follicle Dermal Papilla Cells

María Antonia Martínez‐Pascual, Silvia Sacristán, Elena Toledano‐Macías, María Luisa Hernández‐Bule

Dermal papilla cells (DPCs) regulate the hair cycle and play important roles in hair growth and regeneration. Alopecia is a pathology caused by a deregulation in the hair cycle phases. Currently, the use of physical therapies such as radiofrequency (RF) as an …

es (code pays fourni par la source)

Radiofrequency Currents Modulate Inflammatory Processes in Keratinocytes

Elena Toledano‐Macías, María Antonia Martínez‐Pascual, Almudena Cecilia-Matilla, Mariano Bermejo Martínez et autres

Keratinocytes play an essential role in the inflammatory phase of wound regeneration. In addition to migrating and proliferating for tissue regeneration, they produce a large amount of cytokines that modulate the inflammatory process. Previous studies have shown that subthermal treatment with radiofrequency …

es (code pays fourni par la source)

Effects of RF Electric Currents on Hair Follicle Growth and Differentiation: A Possible Treatment for Alopecia

María Antonia Martínez‐Pascual, Silvia Sacristán, Elena Toledano‐Macías, Pablo Naranjo et autres

Androgenic alopecia (AGA) is the most common type of alopecia and its treatments involve drugs that have various adverse effects and are not completely effective. Radiofrequency-based therapies (RF) are an alternative for AGA treatment. Although there is increasing clinical evidence of the …

es (code pays fourni par la source)

Synergistic Effect of Terbinafine and Blue Light on Reactive Oxygen Species Production in Human Keratinocytes: Potential Implications for Cutaneous Mycosis

Luis Alfonso Pérez-González, María Antonia Martínez‐Pascual, Elena Toledano‐Macías, Rosa Cristina Jara-Laguna et autres

Cutaneous mycoses are common infections whose treatment has become more complex due to increasing antifungal resistance and the need for prolonged therapies, hindering patient adher-ence and increasing the incidence of adverse effects. Consequently, the use of physical therapies, especially photodynamic therapy (PDT), …

es (code pays fourni par la source)

Electric currents of 448 kHz upregulate anti‐senescence pathways in human dermal fibroblasts

Elena Toledano‐Macías, María Antonia Martínez‐Pascual, María Luisa Hernández‐Bule

BACKGROUND: Currently, finding new therapeutic strategies that reduce skin aging is a challenge for dermatologists and aesthetic doctors. In recent years, physical therapies have been included in the options for antiaging treatments; however, the biological bases of such treatments have scarcely been …

es (code pays fourni par la source)

Anti-Fibrotic Effects of RF Electric Currents

María Luisa Hernández‐Bule, Elena Toledano‐Macías, Luis Alfonso Pérez-González, María Antonia Martínez‐Pascual et autres

Hypertrophic scars and keloids are two different manifestations of excessive dermal fibrosis and are caused by an alteration in the normal wound-healing process. Treatment with radiofrequency (RF)-based therapies has proven to be useful in reducing hypertrophic scars. In this study, the effect …

es (code pays fourni par la source)

Effects of RF Currents on Cytokines Production in Human Keratinocytes

María Luisa Hernández‐Bule, Elena Toledano‐Macías, María Antonia Martínez‐Pascual, Alejandro Úbeda et autres

Wound healing consists of a sequence of coordinated phases: inflammation, proliferation, and remodeling. In skin lesions, neutrophils and keratinocytes are the main cell types participating in the inflammatory phase, during which the release of mediators intervening in the regulation of the subsequent …

es (code pays fourni par la source)

Response of human cancer cells to simultaneous treatment with sorafenib and radiofrequency current

María Luisa Hernández‐Bule, María Antonia Martínez, María Ángeles Trillo, Lidia Martínez et autres

Due to their alleged analgesic, anti-inflammatory and tissue regenerative effects, capacitive-resistive electrothermal therapy (CRET), which is based on non-invasive exposure to radiofrequency (RF) currents, is often applied to chemotherapeutically treated patients with cancer. Our previous studies have demonstrated that subthermal CRET currents …

es (code pays fourni par la source)

In vitro stimulation with radiofrequency currents promotes proliferation and migration in human keratinocytes and fibroblasts

María Luisa Hernández‐Bule, Elena Toledano‐Macías, Aida Naranjo, Marina de Andrés-Zamora et autres

Capacitive-resistive electric transfer (CRET) therapies have been proposed as strategies for regeneration of cutaneous tissue lesions. Previous studies by our group have shown that intermittent stimulation with 448 kHz CRET currents at subthermal densities promotes in vitro proliferation of human stem cells …

es (code pays fourni par la source)

In vitro stimulation with radiofrequency currents promotes proliferation and migration in human keratinocytes and fibroblasts

María Luisa Hernández‐Bule, Elena Toledano‐Macías, Aida Naranjo, Marina de Andrés-Zamora et autres

Capacitive-resistive electric transfer (CRET) therapies have been proposed as strategies for regeneration of cutaneous tissue lesions. Previous studies by our group have shown that intermittent stimulation with 448 kHz CRET currents at subthermal densities promotes in vitro proliferation of human stem cells …