Silvia Sacristán

Aptamer-based inhibition of MNK1 reduces pancreatic ductal adenocarcinoma growth by targeting cancer stem cells

Alberto Pérez‐Ruíz, Laura Ruiz-Cañas, Sandra Batres, Raquel Ferreras-Martín et autres

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to late diagnosis, early metastasis and resistance to therapy. Cancer stem cells (CSCs) have been implicated in PDAC aggressiveness and treatment failure. MAP kinase-interacting kinase 1 (MNK1) is overexpressed in …

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Additional file 1 of Aptamer-based inhibition of MNK1 reduces pancreatic ductal adenocarcinoma growth by targeting cancer stem cells

Alberto Pérez‐Ruíz, Laura Ruiz-Cañas, Sandra Batres, Raquel Ferreras-Martín et autres

Supplementary Material 1

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Aptamer-based inhibition of MNK1 reduces pancreatic ductal adenocarcinoma growth by targeting cancer stem cells

Alberto Pérez‐Ruíz, Laura Ruiz-Cañas, Sandra Batres, Raquel Ferreras-Martín et autres

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to late diagnosis, early metastasis and resistance to therapy. Cancer stem cells (CSCs) have been implicated in PDAC aggressiveness and treatment failure. MAP kinase-interacting kinase 1 (MNK1) is overexpressed …

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Aptamer-based inhibition of MNK1 reduces pancreatic ductal adenocarcinoma growth by targeting cancer stem cells

Alberto Pérez‐Ruíz, Laura Ruiz-Cañas, Sandra Batres, Raquel Ferreras-Martín et autres

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to late diagnosis, early metastasis and resistance to therapy. Cancer stem cells (CSCs) have been implicated in PDAC aggressiveness and treatment failure. MAP kinase-interacting kinase 1 (MNK1) is overexpressed …

es, lk (code pays fourni par la source)

Additional file 1 of Aptamer-based inhibition of MNK1 reduces pancreatic ductal adenocarcinoma growth by targeting cancer stem cells

Alberto Pérez‐Ruíz, Laura Ruiz-Cañas, Sandra Batres, Raquel Ferreras-Martín et autres

Supplementary Material 1

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Epigenetic silencing of MAFG is a potential prognosis biomarker in lung adenocarcinomas

Álvaro García-Guede, Carlos Rodríguez‐Antolín, Ana Arauzo-Cabrera, Rocío Moreno-Velasco et autres

ABSTRACT Non-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related mortality, partly because it is often diagnosed at advanced stages and frequently develops resistance to platinum-based chemotherapy. We previously showed that MAFG becomes derepressed following miR-7 hypermethylation, promoting …

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Synthesis & Biological Evaluation of a New Dihydroceramide Desaturase Inhibitor for the Treatment of MASLD.

Karla Ceballos, José Luis Abad, Bihdan Babiy, Álvaro Hidalgo et autres

Electric Stimulation at 448 kHz Modulates Proliferation and Differentiation of Follicle Dermal Papilla Cells

María Antonia Martínez‐Pascual, Silvia Sacristán, Elena Toledano‐Macías, María Luisa Hernández‐Bule

Dermal papilla cells (DPCs) regulate the hair cycle and play important roles in hair growth and regeneration. Alopecia is a pathology caused by a deregulation in the hair cycle phases. Currently, the use of physical therapies such as radiofrequency (RF) as an …

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Radiofrequency Currents Modulate Inflammatory Processes in Keratinocytes

Elena Toledano‐Macías, María Antonia Martínez‐Pascual, Almudena Cecilia-Matilla, Mariano Bermejo Martínez et autres

Keratinocytes play an essential role in the inflammatory phase of wound regeneration. In addition to migrating and proliferating for tissue regeneration, they produce a large amount of cytokines that modulate the inflammatory process. Previous studies have shown that subthermal treatment with radiofrequency …

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Histone Acetyl Transferase 1 Is Overexpressed in Poor Prognosis, High-grade Meningeal and Glial Brain Cancers: Immunohistochemical and Aptahistochemical Study

Sandra Bargiela-Cuevas, María Marin, María Gabaldon-Ojeda, José Ignacio Klett-Mingo et autres

Primary malignancies of the central nervous system account for 2% of all cancers in adults and almost 15% in children under 15 years of age. The prognosis of brain anaplastic cancers and glioblastomas remains extremely poor, with devastating survival expectative, and new …

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Effects of RF Electric Currents on Hair Follicle Growth and Differentiation: A Possible Treatment for Alopecia

María Antonia Martínez‐Pascual, Silvia Sacristán, Elena Toledano‐Macías, Pablo Naranjo et autres

Androgenic alopecia (AGA) is the most common type of alopecia and its treatments involve drugs that have various adverse effects and are not completely effective. Radiofrequency-based therapies (RF) are an alternative for AGA treatment. Although there is increasing clinical evidence of the …

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MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM)

Nieves García-Quintáns, Silvia Sacristán, Cristina Márquez-López, Cristina Sánchez‐Ramos et autres

The most prevalent genetic form of inherited arrhythmogenic cardiomyopathy (ACM) is caused by mutations in desmosomal plakophilin-2 (PKP2). By studying pathogenic deletion mutations in the desmosomal protein PKP2, here we identify a general mechanism by which PKP2 delocalization restricts actomyosin network organization …

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