В. А. Паликов

Modeling Hemorrhagic Shock in Male SD Rats by Fixed Volume Blood Withdrawal Followed by Partial Resuscitation and Long-Term Outcome Assessment

Alina M. Ismailova, В. А. Паликов, Maria S. Severyukhina, Elena A. Tukhovskaya et autres

Background/Objectives: Hemorrhagic shock (HS) is one of the leading causes of disability and mortality in intensive care units. Animal modeling of HS is important for preclinical research to elucidate mechanisms and develop treatments. Methods: Adult male SD rats were divided into three …

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The Efficacy of Experimental Therapy for Stroke Induced by Cerebral Air Embolism in Awake Rats Is Affected by Heliox Inhalation Temperature

Arina V. Kholina, Alina Ismailova, В. А. Паликов, N. A. Borozdina et autres

BACKGROUND: Previous studies have shown that Heliox, a mixture of 32% oxygen and 68% helium administered at a warm temperature, is effective in treating ischemic brain injury caused by cerebral arterial air embolism. At the same time, therapeutic hypothermia has been shown …

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The Critical Role of Steroid Regimen for Lung Repair in Experimental Diffuse Alveolar Damage

Aleksandr S. Chernov, Georgii B. Telegin, E. A. Sinitsyn, Alexey Dmitriev et autres

Acute respiratory distress syndrome (ARDS) is a common condition among intensive care unit patients and is associated with high mortality. Currently, there are no unified therapeutic strategies, including for the use of systemic glucocorticosteroid (GCS) therapy, in the management of ARDS of …

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Differential Immune Response to Hydroxyapatite Precursors Under Inflammatory Pressure: In Vitro and In Vivo Studies

Irina S. Fadeeva, Anastasia Yu. Teterina, Igor V. Smirnov, Vladislav V. Minaychev et autres

The clinical success of calcium phosphate bone grafts (CPs) largely depends on the body's immune response. However, traditional biocompatibility tests use healthy organisms and cannot predict effectiveness in patients with common chronic inflammatory diseases. This study examines how inflammation modulates the immune …

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Awake Rat Model of Ischemic Stroke with Neuropsychiatric Complications During a Seven-Day Observation

В. А. Паликов, Alina M. Ismailova, Vitaly A. Kazakov, Arina V. Kholina et autres

The translational model of experimental stroke in rats induced by a gas embolism was created to clarify the features of stroke's development and to evaluate the neuroprotective effect of novel remedies and proven drugs. The moderately time and labor-consuming protocol allows for …

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Different degrees of expression of pulmonary fibrosis signs with intratracheal administration of bleomycin at different doses in male SD rats (a study aimed at helping to select the optimal bleomycin dose for modeling pulmonary fibrosis)

Elena A. Tukhovskaya, Yulia A. Palikova, Alina M. Ismailova, В. А. Паликов et autres

Background: Pulmonary fibrosis (PF) is a life-threatening lung disease. PF develops under the influence of various damaging agents. To study new therapeutic strategies, a PF model with intratracheal administration of bleomycin (BLM) is used. Methods: We studied the effect of different doses …

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Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Alexey A. Belogurov, Georgii B. Telegin, А. С. Чернов, Anna A. Kudriaeva et autres

Spinal cord injury (SCI) is a medical challenge that results in the formation of a glial scar preventing recovery of axonal conductivity. Cytokines and chemokines significantly affect the pathogenesis of SCI and represent important targets for therapeutic intervention. Here, dozens of cytokines …

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Antitumor Activity of Poloxamer-188 Solution (Myotive) after Oral and Intravenous Administration in Female BALB/c Mice

D. I. Rzhevskiy, R. A. Dalevich, I. N. Kravchenko, E. S. Sadovnikova et autres

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Efficacy of Poloxamer 188 in Experimental Myelosuppression Model Induced by Carboplatin in CBA Mice

Arina V. Kholina, N. A. Borozdina, В. А. Паликов, Evgeniy S. Mikhaylov et autres

Poloxamer 188 is a polymer that is used as a carrier and stabilizer of pharmacological agents. It has been demonstrated to enhance red blood cell and hemoglobin levels in healthy animals and in select clinical cases. The objective of this study was …

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Study of Behavioral Disorders in Laboratory Animals Using a Model of Unpredictable Chronic Mild Stress

Vladimir M. Pavlov, В. А. Паликов, A. Yu. Fedotova, Maksim V. Shinelev et autres

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Two Amino Acid Substitutions Improve the Pharmacological Profile of the Snake Venom Peptide Mambalgin

Dmitry I. Osmakov, Timur A. Khasanov, Ekaterina E. Maleeva, Vladimir M. Pavlov et autres

Mambalgins are peptide inhibitors of acid-sensing ion channels type 1 (ASIC1) with potent analgesic effects in models of inflammatory and neuropathic pain. To optimize recombinant peptide production and enhance pharmacological properties, we developed a mutant analog of mambalgin-1 (Mamb) through molecular modeling …

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Sea anemone Cys‐ladder peptide Ms13‐1 induces a pain response as a positive modulator of acid‐sensing ion channel 1a

Timur A. Khasanov, Константин С. Минеев, Aleksandr P. Kalinovskii, Yuliya V. Korolkova et autres

Acid-sensing ion channel 1a (ASIC1a) is involved in processes associated with fear, learning, and neurodegeneration within the central nervous system. However, ASIC1a is also abundant in the peripheral nervous system, where its role is still poorly understood, largely due to the lack …

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