Accès ouvert
2026
article
OpenAlex
Alina M. Ismailova, В. А. Паликов, Maria S. Severyukhina, Elena A. Tukhovskaya et autres
Background/Objectives: Hemorrhagic shock (HS) is one of the leading causes of disability and mortality in intensive care units. Animal modeling of HS is important for preclinical research to elucidate mechanisms and develop treatments. Methods: Adult male SD rats were divided into three …
ru
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Accès ouvert
2026
article
OpenAlex
Arina V. Kholina, Alina M. Ismailova, В. А. Паликов, N. A. Borozdina et autres
BACKGROUND: Previous studies have shown that Heliox, a mixture of 32% oxygen and 68% helium administered at a warm temperature, is effective in treating ischemic brain injury caused by cerebral arterial air embolism. At the same time, therapeutic hypothermia has been shown …
ru
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Accès ouvert
2026
article
OpenAlex
Irina S. Fadeeva, Anastasia Yu. Teterina, Igor V. Smirnov, Vladislav V. Minaychev et autres
The clinical success of calcium phosphate bone grafts (CPs) largely depends on the body's immune response. However, traditional biocompatibility tests use healthy organisms and cannot predict effectiveness in patients with common chronic inflammatory diseases. This study examines how inflammation modulates the immune …
ru
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2025
article
OpenAlex
В. А. Паликов, Alina M. Ismailova, Vitaly A. Kazakov, Arina V. Kholina et autres
The translational model of experimental stroke in rats induced by a gas embolism was created to clarify the features of stroke's development and to evaluate the neuroprotective effect of novel remedies and proven drugs. The moderately time and labor-consuming protocol allows for …
ru
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Accès ouvert
2025
article
OpenAlex
Arina V. Kholina, N. A. Borozdina, В. А. Паликов, Evgeniy S. Mikhaylov et autres
Poloxamer 188 is a polymer that is used as a carrier and stabilizer of pharmacological agents. It has been demonstrated to enhance red blood cell and hemoglobin levels in healthy animals and in select clinical cases. The objective of this study was …
ru
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Accès ouvert
2025
article
OpenAlex
В. А. Шипелин, Arina V. Kholina, Anna V. Zamyatina, V K Mazo et autres
. The experiment demonstrated the presence of immunoadjuvant properties in PC concentrate and Module, especially expressed in the Module-200 group. The Module had immunostimulating effect on cell-mediated immunity. The manifestation of the Module effects, in contrast to the PC concentrate, is apparently …
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