Accès ouvert
2021
article
OpenAlex
Dan F. Spandau, Roy Chen, Jeffrey J. Wargo, Craig A. Rohan et autres
BACKGROUNDThe loss of insulin-like growth factor 1 (IGF-1) expression in senescent dermal fibroblasts during aging is associated with an increased risk of nonmelanoma skin cancer (NMSC). We tested how IGF-1 signaling can influence photocarcinogenesis during chronic UVB exposure to determine if fractionated …
us
(code pays fourni par la source)
2016
article
OpenAlex
Mathew Loesch, Ann Collier, David Southern, Rachel Elizabeth Ward et autres
The activation status of the insulin-like growth factor-1 receptor (IGF-1R) regulates the cellular response of keratinocytes to ultraviolet B (UVB) exposure, both in vitro and in vivo. Geriatric skin is deficient in IGF-1 expression resulting in an aberrant IGF-1R-dependent UVB response which …
us
(code pays fourni par la source)
2016
book-chapter
OpenAlex
Davina A. Lewis, Aleksandar Krbanjevic, Jeffrey Bryant Travers, Dan F. Spandau
us
(code pays fourni par la source)
Accès ouvert
2016
article
OpenAlex
Mathew Loesch, Ann Collier, David Southern, Rachel Elizabeth Ward et autres
The activation status of the insulin-like growth factor-1 receptor (IGF-1R) regulates the cellular response of keratinocytes to ultraviolet B (UVB) exposure, both in vitro and in vivo. Geriatric skin is deficient in IGF-1 expression resulting in an aberrant IGF-1R-dependent UVB response which …
us
(code pays fourni par la source)
Accès ouvert
2015
book-chapter
OpenAlex
Davina A. Lewis, Aleksandar Krbanjevic, Jeffrey Bryant Travers, Dan F. Spandau
The cocktail of sun’s ultraviolet (UVB) rays, and the hands of father time, can significantly increase the risk of skin cancers. However, genetic predisposition, certain skin diseases, and some viral infections can also increase the risk of skin cancers. Nonmelanoma skin cancer …
us
(code pays fourni par la source)
Accès ouvert
2013
article
OpenAlex
Jeffrey Bryant Travers, Dan F. Spandau, Davina A. Lewis, Christiane Machado et autres
BACKGROUND: Squamous cell carcinoma (SCC), which has one of the highest incidences of all cancers in the United States, is an age-dependent disease, with the majority of these cancers diagnosed in people age 70 and older. Recent findings have led to a …
us
(code pays fourni par la source)
2012
article
OpenAlex
Kelly K. Hiatt, Davina A. Lewis, Matthew A. Shew, Khadijeh Bijangi‐Vishehsaraei et autres
Muscle progenitor cells (MPCs) are currently being investigated as cellular vectors to deliver neurotrophic factor (NF) for the promotion of re-innervation after axonal injury. Ideally NF delivery in such a model would enhance axonal regeneration while simultaneously promoting MPC viability. To date, …
us
(code pays fourni par la source)
Accès ouvert
2012
article
OpenAlex
Dan F. Spandau, Davina A. Lewis, A.-K. Somani, Jeffrey Bryant Travers
us
(code pays fourni par la source)
Accès ouvert
2011
article
OpenAlex
Davina A. Lewis, Jeffrey Bryant Travers, Christiane Machado, Ally-Khan B. Somani et autres
The accumulation of senescent stromal cells in aging tissue changes the local microenvironment from normal to a state similar to chronic inflammation. This inflammatory microenvironment can stimulate the proliferation of epithelial cells containing DNA mutations which can ultimately lead to cancer. Using …
us
(code pays fourni par la source)
2009
book-chapter
OpenAlex
Davina A. Lewis, Jeffrey Bryant Travers, Dan F. Spandau
us
(code pays fourni par la source)
Accès ouvert
2008
article
OpenAlex
Davina A. Lewis, Jeffrey Bryant Travers, Dan F. Spandau
us
(code pays fourni par la source)
Accès ouvert
2008
article
OpenAlex
Davina A. Lewis, Qiaofang Yi, Jeffrey Bryant Travers, Dan F. Spandau
To cope with the frequent exposure to carcinogenic UV B (UVB) wavelengths found in sunlight, keratinocytes have acquired extensive protective measures to handle UVB-induced DNA damage. Recent in vitro and epidemiological data suggest one these protective mechanisms is dependent on the functional …
us, cz
(code pays fourni par la source)