Aging-Associated Nonmelanoma Skin Cancer: A Role for the Dermis
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Le résumé fourni par la source
The cocktail of sun’s ultraviolet (UVB) rays, and the hands of father time, can significantly increase the risk of skin cancers. However, genetic predisposition, certain skin diseases, and some viral infections can also increase the risk of skin cancers. Nonmelanoma skin cancer (NMSC), including basal cell (BCC) and squamous cell carcinoma (SCC), is thought to be based on a life time exposure to risk factors such as UV radiation combined with little sun protection in that life time. In fact, over 80 % of all skin cancers are found in people over the age of 60. NMSC tends to occur on highly visible areas such as the head, face, and neck. The treatment of these NMSC represents both a significant economic burden to health services and can cause significant morbidity especially as these occur on highly visible areas. Treatment is often invasive surgery which often leads to scaring and affects quality of life. Other treatments are based on chemotherapeutic, immunotherapies that can also affect quality of life. While very effective standard treatments have been developed to treat NMSC, very little is understood about the underlying cellular causes, and as such, alternative methods of treatment have not readily been developed. In this chapter, we explore the mechanisms of UVB-induced effects on skin and exciting new possible methods to treat NMSC. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Aging-Associated Nonmelanoma Skin Cancer: A Role for the Dermis
- Date Crossref
- 01/01/2015
- Éditeur
- Springer Berlin Heidelberg
- Type
- book-chapter
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Covance (United States) pays non établi dans la noticeEntreprise
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Indiana University School of Medicine Department of Dermatology pays non établi dans la noticeUniversité ou école supérieure
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Indiana University – Purdue University Indianapolis pays non établi dans la noticeUniversité ou école supérieure
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Wright State University Departments of Pharmacology & Toxicology and Dermatology pays non établi dans la noticeUniversité ou école supérieure
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Department of Anatomic Pathology & Histology pays non établi dans la noticeInstitution
Covance (United States), Department of Dermatology — Indiana University School of Medicine et Indiana University – Purdue University Indianapolis, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.