Jamie E. Sly

Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate‐based formulations for genotoxic activity using in vitro assays

Stephanie L. Smith‐Roe, Carol D. Swartz, Asma Rashid, Nicholas C. Christy et autres

Glyphosate, the most heavily used herbicide world-wide, is applied to plants in complex formulations that promote absorption. The National Toxicology Program reported in 1992 that glyphosate, administered to rats and mice at doses up to 50,000 ppm in feed for 13 weeks, …

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Using the HepaCometChip Assay for Broad‐Spectrum DNA Damage Analysis

Norah A. Owiti, Simran Kaushal, Lincoln Martin, Jamie E. Sly et autres

Exposure to DNA damaging agents can lead to mutations that cause cancer. The liver is particularly vulnerable because it contains high levels of Cytochrome P450 enzymes that can convert xenobiotics into DNA reactive metabolites that form potentially carcinogenic bulky DNA adducts. As …

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Comet assay in rat lung, bronchoalveolar lavage (BAL) cells and nasal tissue, site of contact tissues in inhalation studies

Kamala Pant, Shannon Wilson Bruce, Sandra Ann Springer, Michelle Klug Laforce et autres

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Bacterial mutagenicity assays: Vehicle and positive control results from the standard Ames assay, the 6‐ and 24‐well miniaturized plate incorporation assays and the Ames II™ assay

Kamala Pant, Shannon Wilson Bruce, Jamie E. Sly, Michelle Klug Laforce et autres

Bacterial mutation assays are conducted routinely as part of the safety assessment of new chemicals. The OECD Test Guideline (TG) 471 describes the conduct of the standard agar plate Ames assay, required for regulatory submissions. Higher throughput non-OECD 471 TG assays, such …

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Combination comet/micronucleus assay validation performed by BioReliance under the JaCVAM initiative

Kamala Pant, Ljubica Krsmanovic, Shannon Wilson Bruce, Tawney Kelley et autres

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Prevalidation study of the Syrian hamster embryo (SHE) cell transformation assay at pH 7.0 for assessment of carcinogenic potential of chemicals

Marie‐Aline Maire, Kamala Pant, Albrecht Poth, Karl-Rainer Schwind et autres

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Photo catalogue for the classification of cell colonies in the Syrian hamster embryo (SHE) cell transformation assay at pH 6.7

Susanne Bohnenberger, Shannon Wilson Bruce, Thorsten Kunkelmann, Kamala Pant et autres

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Recommended protocol for the Syrian hamster embryo (SHE) cell transformation assay

Marie‐Aline Maire, Kamala Pant, Pascal Phrakonkham, Albrecht Poth et autres

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Prevalidation study of the Syrian hamster embryo (SHE) cell transformation assay at pH 6.7 for assessment of carcinogenic potential of chemicals

Kamala Pant, Shannon Wilson Bruce, Jamie E. Sly, Thorsten Kunkelmann et autres

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Assessment of genotoxicity induced by 7,12‐dimethylbenz(a)anthracene or diethylnitrosamine in the Pig‐a, micronucleus and Comet assays integrated into 28‐day repeat dose studies

Jing Shi, Ljubica Krsmanovic, Shannon Wilson Bruce, Tawney Kelly et autres

As part of the Stage 3 of the Pig-a international trial, we evaluated 7,12-dimethylbenz(a)anthracene (DMBA) for induction of Pig-a gene mutation using a 28-day repeat dose study design in Sprague-Dawley rats. In the same study, chromosomal damage in peripheral blood and primary …

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An international validation study of a Bhas 42 cell transformation assay for the prediction of chemical carcinogenicity

Ayako Sakai, Kiyoshi Sasaki, Kumiko Hayashi, Dai Muramatsu et autres

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Syrian Hamster Embryo (SHE) cell transformation assay with and without X-ray irradiation of feeder cells using Di(2-ethylhexyl)phthalate (DEHP) and N-nitroso-N-methylnitroguanidine (MNNG)

Kamala Pant, Jamie E. Sly, Shannon Wilson Bruce, Andrew D. Scott et autres

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