Alper Togay

Real-World Concordance of Indirect Immunofluorescence and Antigen-Specific Assays in Antineutrophil Cytoplasmic Antibody Testing: A Retrospective High-Volume Laboratory Study

Ayşe Arslan, Alper Togay

BACKGROUND: Current guidelines recommend myeloperoxidase (MPO)- and proteinase 3 (PR3)-based immunoassays as the primary approach for antineutrophil cytoplasmic antibody (ANCA) testing, while indirect immunofluorescence (IIF) is reserved for selected clinical contexts. However, real-world data regarding concordance and workflow implications of these approaches …

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Sarcopenia Evaluation in Multiple Myeloma Patients Before and After Autologous Stem Cell Transplantation: A Prospective Study

Elçin Erdoğan Yücel, G. H. Ozsan, Caner Öztürk, Alper Togay et autres

Purpose The aim of this study is to assess the presence of sarcopenia in multiple myeloma (MM) patients both before and after autologous stem cell transplantation (ASCT) and to investigate if ASCT is a causative factor for sarcopenia. This study is the …

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Impact of pre-transplant serum levels of activin A, activin B, IGF-1 and IL-6 on transplant outcomes and survival in patients with multiple myeloma: a prospective study.

Elçin Erdoğan Yücel, G. Hayri Özsan, Alper Togay, O C Oztur et autres

OBJECTIVE: This prospective study aimed to assess the impact of activin A/B, interleukin 6 (IL-6) and insulin-like growth factor-1 (IGF-1) on end-organ damage, clinical outcomes of high-dose chemotherapy-supported autologous stem cell transplantation (ASCT) and survival rates. MATERIALS AND METHODS: The serum cytokine …

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Tıp Fakülteleri için Mikrobiyoloji ve İmmunoloji Kitabı

Tuba Müderris, Filiz Sağlam, İpek Mumcuoğlu, Esra Tavukcu et autres

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Tümör İmmünitesi

Alper Togay

Tümör immünolojisi, bağışıklık sisteminin kanser hücrelerine karşı yanıtını inceleyen bir alandır. Kanser, dünya çapında önemli bir sağlık sorunudur ve çocuklarda ve yetişkinlerde yüksek morbidite ve mortaliteye neden olmaktadır. Kanser hücreleri, kontrolsüz büyüme yetenekleriyle normal dokulara zarar vererek hastalığa yol açar. Bağışıklık sistemi, …

Retrospective Analysis of Acute Promyelocytic Leukemia; A Single-center Experience

Hale Bülbül, Alper Togay

ÖzObjective: Acute myeloid leukemia (AML) is an uncommon illness in and of itself.Approximately 10% of AML cases have acute promyelocytic leukemia (APL), a particularly severe form of the disease.There is a dearth of information on Turkish patients with APL.Thus, our goal was …

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Association of Several Innate Immune Response Gene Polymorphisms with COVID-19 in Turkish Population

Mustafa Soyöz, Zeynep Altın, Aslı Eldem, Alper Togay et autres

Aim: The coronavirus disease 2019 (COVID-19) was caused by severe acute respiratory syndrome 2 virus (SARS-CoV-2), has spread globally. Gender and age have been established as risk factors for severe COVID-19. However, these factors do not fully explain the effects on disease …

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Retrospective evaluation of “Rods and Rings” pattern detected in the anti-nuclear antibody (ANA) indirect immunofluorescence (IIF) test

Neşe İnal, Berke Kurumanastırlı, Tutku Taşkınoğlu, Alev Çetin Duran et autres

Introduction: Anti-rods and rings (anti-RR) antibodies have recently been described as a cytoplasmic pattern in IIF-based screening of autoantibodies on HEp-2 cells and ICAP has named it as AC-23. It is most frequently related to drug-induced antibody generation. This study aimed to …

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Comparison of External and Internal Site Genital Sampling to Detect High-Risk HPV DNA in Women

Esin Kasap, Can Türkler, Nisel Yılmaz, Gökşen Görgülü et autres

BACKGROUND: Human papillomavirus (HPV), the most common pathogen causing sexually transmitted diseases worldwide, is also an oncogenic virus. Due to the inadequacy of serologic tests in the diagnosis of HPV, NAATs (nucleic acid amplification tests), such as PCR (polymerase chain reaction), represent …

The effect of anti-phospholipid syndrome on pregnancy outcomes in patients with habitual abortus

Alper Togay, Duygu Tekin, Mehmet Özer, Özden Sıla Kılınç Gönüllü

Objective: The aim of this study was to research the pregnancy outcomes of women with anti-beta2 glycoprotein 1 and anti-cardiolipin antibody positivity and to determine the association with pregnancy morbidity. Materials and methods: This retrospective study contained pregnant women with anti-beta2 glycoprotein …

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Automatic Classification of Antinuclear Antibody Patterns With Machine Learning

Barış Boral, Alper Togay

Antinuclear antibodies (ANA) are important diagnostic markers in many autoimmune rheumatological diseases. The indirect immunofluorescence assay applied on human epithelial cells generates images that are used in the detection of ANA. The classification of these images for different ANA patterns requires human …

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Investigation of the Efficacy Results of Atmospheric Cold Plasma Against Multi-Resistant Bacterial Strains

Alper Togay, Duygu Tekin, Şeyma Ecem IRMAK, Utku Kürşat Ercan et autres

Giriş: Amacımız Atmosferik Soğuk Plazma ile muamele edilmiş PBS'nin Gram pozitif ve Gram negatif çoklu ilaca dirençli bakterilere karşı etkinliğini araştırmaktır. Gereç ve Yöntemler: Toplam 50 karbapenem dirençli Klebsiella pneumoniae ve 10 vankomisin dirençli Enterococcus faecium suşu çalışmaya dahil edilmiştir. 100 µl …

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