Ruth C. Wilkins

The EPRBioDose2024 Conference Proceedings

Tomisato Miura, Ann Barry Flood, Nadica Maltar‐Strmečki, Ruth C. Wilkins et autres

jp, us, gb, hr, ca (code pays fourni par la source)

Evaluation of chromosome aberrations in astronaut lymphocytes after long-duration missions to the International Space Station

Benjamin Puzantian, Lindsay A. Beaton-Green, Paul Grzegorcyk, Vita Lai et autres

The Health Canada and the National Aeronautics and Space Administration biodosimetry programmes have assessed exposure of astronauts to ionizing radiation based on the frequency of chromosomal aberrations in lymphocytes after missions to the International Space Station. These assessments were performed by the …

ca, us (code pays fourni par la source)

Transcriptomic and proteomic assessment of radiation injury and dose-rate dependency in white blood cells

Sanjeena Subedi, Saadia Khilji, Ngoc Q. Vuong, Caitlin Kral et autres

Abstract Ionizing radiation elicits complex cellular responses that are influenced not only by total dose but also by the rate at which the dose is delivered. Understanding how dose rate modulates molecular outcomes is important for accurate risk assessment. In this study, …

ca (code pays fourni par la source)

Medical Radiation Exposures in Canada: 2017

Julie J. Burtt, Seshan Anandarajah, Andra Morrison, Ruth C. Wilkins

Radiation-based medical techniques and devices provide significant benefits to patients through the diagnosis, treatment, and management of illness and disease. Documenting trends and frequency of use offer important insights into radiation protection and help address gaps in the documentation of medical exposures. …

ca (code pays fourni par la source)

Re-envisioning the North American Biodosimetry Assessment Networking Group

Merriline M. Satyamitra, Adayabalam S. Balajee, William F. Blakely, C. Norman Coleman et autres

roup (BANG) by developing a blueprint for integrating the relevant national capabilities to provide emergency biodosimetry assistance in civilian populations following a radiological or nuclear incident. The goals of BANG are to: 1) establish a collaborative network (public/private partnership) and engage its …

us, ca (code pays fourni par la source)

Perspectives of IABERD on biodosimetry strategies for a large-scale nuclear event

Adayabalam S. Balajee, Christophe Badie, Ann Barry Flood, Evagelia C. Laiakis et autres

Purpose: Performing biodosimetry assessment for several hundreds of thousands of individuals in the aftermath of large scale radiological/nuclear incidents will be technically challenging. The purpose of this review is to provide logistical planning to determine when, how and which biodosimetry tools can …

us, it, hr, de, no, fr, ca, jp (code pays fourni par la source)

Adverse Outcome Pathways Applied to Space Radiation Research

Vinita Chauhan, Veronica S. Grybas, Devyn Hoopfer, Casey Higginson et autres

Long-duration spaceflight exposes astronauts to various stressors that can alter human physiology, potentially causing immediate and long-term health effects. These stressors can damage biomolecules, cells, tissues, and organs, leading to adverse outcomes. Developing adverse outcome pathways (AOPs) relevant to radiation exposure can …

ca, gb, de, us, fr, jp (code pays fourni par la source)

Dose-response modeling reveals multifaceted molecular responses to low-dose radiation in human white blood cells

Saadia Khilji, Ngoc Q. Vuong, Andrew J. Williams, Kelly M. Fulton et autres

BACKGROUND: The current radiation protection framework extrapolates health risks from high-dose exposures based on a linear, no-threshold model. However, empirical data on molecular effects below 0.1 Gy are lacking, creating uncertainties in risk assessments. To address this, we used benchmark dose (BMD) …

ca (code pays fourni par la source)

Application of an imaging flow cytometry γ-H2AX assay for biodosimetry using supervised machine learning

Eman M. Hassan, Benjamin Puzantian, Jessica M. Mayenburg, Melody Li et autres

PURPOSE: Phosphorylation of the histone H2AX (γ-H2AX) is a rapid response to radiation-induced DNA double strand breaks (DSBs) and is a good biomarker for exposure to ionizing radiation. The signal has traditionally been detected by microscopy (spot counting) or by flow cytometry …

ca (code pays fourni par la source)

Adverse Outcome Pathway on Deposition of Energy Leading to Abnormal Vascular Remodeling

Tatiana Kozbenko, Nadine Adam, Veronica S. Grybas, Ben J. Smith et autres

The present Adverse Outcome Pathway (AOP) outlines the progression from deposition of energy by radiation exposure to abnormal vascular remodeling, a precursor to cardiovascular disease. The initiating event is the deposition of energy in vascular tissues during ionizing radiation exposure, leading to …

Adverse Outcome Pathway on Deposition of Energy Leading to Cataracts

Emma Carrothers, Meghan Appleby, Vita Lai, Tatiana Kozbenko et autres

The present Adverse Outcome Pathway (AOP) describes the development of cataracts following ionizing radiation exposure, beginning with the deposition of energy into cells of the eye. This event generates an excess of reactive oxygen species, leading to oxidative stress when the balance …

Adverse Outcome Pathway on Deposition of Energy Leading to Occurrence of Bone Loss

Snehpal Sandhu, Mitchell Keyworth, Syna Karimi‐Jashni, Dalya Alomar et autres

The present Adverse Outcome Pathway (AOP) describes the linkage between bone loss and the deposition of energy by radiation, a prototypic stressor relevant to spaceflight and radiotherapy. The initial ionization events cause oxidative stress, defined as an imbalance between oxidants and antioxidants, …