Accès ouvert
2025
article
OpenAlex
Eman M. Hassan, Benjamin Puzantian, Jessica M. Mayenburg, Melody Li et autres
PURPOSE: Phosphorylation of the histone H2AX (γ-H2AX) is a rapid response to radiation-induced DNA double strand breaks (DSBs) and is a good biomarker for exposure to ionizing radiation. The signal has traditionally been detected by microscopy (spot counting) or by flow cytometry …
ca
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Accès ouvert
2024
article
OpenAlex
Lindsay A. Beaton-Green, Jessica M. Mayenburg, Leonora Marro, Sarita Cuadros Sanchez et autres
In the event of a large-scale incident involving radiological or nuclear exposures, there is a potential for large numbers of individuals to have received doses of radiation sufficient to cause adverse health effects. It is imperative to quickly identify these individuals in …
ca
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Leah Nemzow, Thomas Boehringer, Jessica M. Mayenburg, Lindsay A. Beaton-Green et autres
In the event of a widespread radiological incident, thousands of individuals will require rapid assessment of exposure using validated biodosimetry assays to inform clinical triage. In this scenario, multiple biodosimetry laboratories may be necessary for large-volume sample processing. To meet this need, …
us, ca
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Lindsay A. Beaton-Green, Jessica M. Mayenburg, Leonora Marro, Eman M. Hassan et autres
The cytokinesis-block micronucleus assay is a well-established method to assess radiation-induced genetic damage in human cells. This assay has been adapted to imaging flow cytometry (IFC), allowing automated analysis of many cells, and eliminating the need to create microscope slides. Furthermore, to …
ca, us
(code pays fourni par la source)