Fazıl Çağrı Hunutlu

Prognostic Value of the Modified Endothelial Activation and Stress Index (m-EASIX) for 90-Day Mortality in Patients with Moderate-to-Severe Hypercalcemia of Malignancy

Gül ADA, Hikmet Öztop, Fazıl Çağrı Hunutlu

Background: Hypercalcemia of malignancy (HCM) is associated with poor short-term prognosis, particularly when it represents the initial manifestation of an underlying, as yet uncharacterized malignancy. Serum calcium concentration alone may not adequately capture the systemic biological burden associated with advanced disease. Methods: …

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CORE-PH: A 3-Component Score for Long-Term Mortality Risk in a Pulmonary Arterial Hypertension Cohort

Çetin Alak, Furkan Fatih Yurdalan, Fazıl Çağrı Hunutlu, Zeynep Kumral et autres

Background/Objectives: Pulmonary arterial hypertension (PAH) risk tools do not jointly capture right ventricular adaptation, systemic oxygen balance, and nutritional reserve. We developed the three-component CORE-PH score and assessed its association with long-term mortality. Methods: This retrospective, single-center study included 105 treatment-naïve adults …

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Exploratory Analysis of the C-Reactive Protein–Albumin–Lymphocyte Index and Progression-Free Survival in Early-Stage Classical Hodgkin Lymphoma

Tuba Güllü Koca, Nizameddin Koca, Fazıl Çağrı Hunutlu, Sinem Çubukçu et autres

An easily accessible biomarker to predict early relapse in early-stage classical Hodgkin lymphoma (cHL) remains an unmet clinical need, and this study explored whether the C-reactive protein–albumin–lymphocyte (CALLY) index provides prognostic information in this setting. Ninety-three patients with early-stage cHL treated with …

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Rituximab Outcomes and Predictors of Treatment Failure in Primary Membranous Nephropathy: A Retrospective Cohort Study

Saide Elif Güllülü Boz, Fazıl Çağrı Hunutlu, Esra Çelik, Abdullah İbrahim Çalışır et autres

Background/Objectives: Rituximab (RTX) is an established treatment for primary membranous nephropathy (PMN); however, real-world data on predictors of response and the influence of previous treatment status remain limited. We evaluated outcomes and predictors of treatment failure in PMN patients treated with RTX. …

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Modified Endothelial Activation and Stress Index (mEASIX) Predicts Long-Term Mortality in Patients with Acute Coronary Syndromes

Çetin Alak, Kaan Turhan, Fazıl Çağrı Hunutlu, Zeynep Kumral et autres

Endothelial dysfunction, inflammation, and microvascular injury are key mechanisms involved in the development and progression of acute coronary syndrome (ACS). The Endothelial Activation and Stress Index (EASIX) and its derivatives have emerged as readily available biomarkers of endothelial stress; however, the prognostic …

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Panniculitis-like T-cell Lymphoma: Two Different Diseases and Same Imitator

Ferdi Öztürk, Yunus Toso, Fazıl Çağrı Hunutlu, Şaduman Balaban Adım et autres

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Response to “Comment on: Association of SUVmax with Malignancy in Focal FDG-Avid Thyroid Incidentalomas”

Hikmet Öztop, Fazıl Çağrı Hunutlu, Elif İşleyen Çolak, Seçkin Bilgiç et autres

We read with interest the study by Öztürk et al. evaluating the performance of ultrasound risk stratification systems in focal FDG-avid thyroid incidentalomas. While TIRADS-based systems have shown high diagnostic performance, the SUVmax cut-off value and negative predictive value reported in their …

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Total Pectoral Muscle Area and Prognostic Nutritional Index Provide Complementary Prognostic Information for Patients Hospitalized with HFmrEF/HFrEF

Çetin Alak, Hasan Emin Kaya, Fazıl Çağrı Hunutlu, Muhammed Batuhan Daştan et autres

Background: Skeletal muscle depletion and malnutrition are common in heart failure (HF) and are associated with poor outcomes. Whether imaging-derived skeletal muscle reserve and laboratory-based nutritional indices provide complementary prognostic information remains unclear. We evaluated the prognostic value of total pectoral muscle …

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Assessment of Treatment Response in Patients Diagnosed with Waldenström’s Macroglobulinemia: Single-Center Experience

Şeyma Yavuz, Vildan Özkocaman, Vildan Gürsoy, Tuba Ersal et autres

Waldenström macroglobulinemia (WM) is a rare lymphoplasmacytic lymphoma characterized by the production of monoclonal IgM. It may lead to symptoms such as hyperviscosity syndrome, anemia, and neuropathy. The indication for treatment is not based on a specific IgM level but is determined …

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Pre-Transplant Endothelial Activation and Stress Index (EASIX) and Albumin-Modified mEASIX (mEASIX_alb) Predict Survival in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation

Tuba Güllü Koca, Nizameddin Koca, Fazıl Çağrı Hunutlu, Sinem Çubukçu et autres

Background and Objectives: Endothelial dysfunction is increasingly recognized as a key determinant of transplant outcomes. The Endothelial Activation and Stress Index (EASIX), originally validated in allogeneic stem cell transplantation, integrates markers of endothelial stress into a single composite score. Its prognostic role …

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Real-World Outcomes of Belinostat in Relapsed Refractory T-Cell Lymphomas: A Report from the Lymphoma Study Group of Turkish Society of Hematology

Meral Uluköylü Mengüç, Fatma Inci Arikan, Pelin Aytan, Hüseyin Saffet Beköz et autres

Background: T-cell lymphomas (TCLs) constitute a heterogeneous group of mature T-cell neoplasms characterized by aggressive clinical behavior and poor outcomes, particularly in the relapsed/refractory (R/R) setting. Belinostat is a pan-HDAC inhibitor approved for R/R peripheral T-cell lymphomas. In this retrospective study, we …

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Evaluation of the frequency, risk factors, and outcomes of splanchnic vein thrombosis in myeloproliferative neoplasms: a retrospective cohort study

Ufuk Demirci, Mehmet Baysal, Elif Aksoy, Metban Mastanzade et autres

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