Pelin Aytan

The Comparative Prognostic Value of the Interim PET Deauville Score and ΔSUVmax in Classical Hodgkin Lymphoma: A Real-World Study of Imaging and Inflammatory Markers

Sinan Mersin, Hüseyin Yanık, Zehra Pınar Koç, Pelin Özcan Kara et autres

Background: Interim [18F]FDG-PET/CT with the Deauville score (DS) is central to response assessment in classical Hodgkin lymphoma (cHL). Quantitative ΔSUVmax and the lymphocyte-to-monocyte ratio (LMR) may refine the DS, but ΔSUVmax thresholds vary across cohorts and have rarely been compared. We tested …

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Prognostic Value of Preoperative Inflammatory, Hematological, and Metabolic Blood Indices in Endometrioid-Type Endometrial Cancer: A Retrospective Cohort Study

Görkem Ülger, Kasım Akay, Hamza Yıldız, Pelin Aytan et autres

Background and Objectives: Peripheral blood indices have been proposed as prognostic biomarkers in endometrial cancer, but most reports include mixed histological subtypes, do not control for benign uterine pathology that independently alters hematological profiles, and evaluate these indices in isolation. We evaluated …

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PA-343 PFS2 Outcomes in DREAMM-8: Belantamab Mafodotin (Belamaf)-Pomalidomide-Dexamethasone (BPd) vs Pomalidomide-Bortezomib-Dexamethasone (PVd) in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Güldane Cengiz-Seval, Sosana Delimpasi, Vladimir Vorobyev, Hang Quach et autres

Real-World Outcomes of Belinostat in Relapsed Refractory T-Cell Lymphomas: A Report from the Lymphoma Study Group of Turkish Society of Hematology

Meral Uluköylü Mengüç, Fatma Inci Arikan, Pelin Aytan, Hüseyin Saffet Beköz et autres

Background: T-cell lymphomas (TCLs) constitute a heterogeneous group of mature T-cell neoplasms characterized by aggressive clinical behavior and poor outcomes, particularly in the relapsed/refractory (R/R) setting. Belinostat is a pan-HDAC inhibitor approved for R/R peripheral T-cell lymphomas. In this retrospective study, we …

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Disease Subtype and Procedural Determinants of Leukapheresis Efficacy: A Retrospective Single-Center Study

Sinan Mersin, Pelin Aytan, Seher Yontar, Mahmut Bakır Koyuncu et autres

Background/Objectives: Therapeutic leukapheresis is widely used to manage hyperleukocytosis in hematologic malignancies, yet the factors determining its efficacy remain incompletely defined. We aimed to identify clinical, biochemical, and procedural determinants of leukapheresis efficacy in a single-center cohort. Methods: We retrospectively analyzed 125 …

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Safety profile and predictors of procedural complications in automated erythrocytapheresis for sickle cell disease: a single-center retrospective cohort study

Sinan Mersin, Pelin Aytan, Seher Yontar, Hamit Ünver et autres

Aims: Automated erythrocytapheresis (red cell exchange; RCE) is an established therapeutic modality in sickle cell disease (SCD), yet procedural complication data from Turkey and the Eastern Mediterranean region remain limited. This study evaluated the safety profile of RCE in adult SCD patients …

Flow cytometric analysis of T-cell subsets and platelet surface markers in patients with immune thrombocytopenia: a case-control study

Merve Kara, Pelin Aytan, Cemil Gülüm, Mehmet Burak Yavuz Çimen

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased platelet destruction and impaired platelet production. The role of T-cell subsets and platelet surface markers in ITP pathogenesis remains incompletely understood. To evaluate T-cell subpopulations and platelet surface marker expression in patients …

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PFS2 outcomes by prior therapy from DREAMM-8: A phase 3 study assessing belantamab mafodotin (belamaf), pomalidomide, and dexamethasone (BPd) vs pomalidomide, bortezomib, and dexamethasone (PVd) in patients (pts) with relapsed/refractory multiple myeloma (RRMM).

Güldane Cengiz Seval, Sosana Delimpasi, Vladimir I. Vorobyev, Hang Quach et autres

7566 Background: B-cell maturation antigen (BCMA)–directed therapies have transformed the treatment landscape in RRMM. Belamaf, a BCMA-targeting antibody-drug conjugate, in combination with Pd significantly improved progression-free survival (PFS) vs PVd (hazard ratio [HR], 0.52; 95% CI, 0.37-0.73; P <0.001) in pts with …

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Monocyte engraftment dynamics and flow cytometric analysis in allogeneic and autologous peripheral blood stem cell transplantation: a prospective study

Delal Melik, Pelin Aytan, Cemil Gülüm, Mehmet Burak Yavuz Çimen

BACKGROUND: Hematopoietic stem cell transplantation (HSCT) success relies on timely engraftment and immune reconstitution. While neutrophil and platelet recovery are well-established clinical endpoints, the dynamics of monocyte engraftment and their relationship with hematopoietic recovery remain insufficiently characterized. METHODS: In this prospective observational …

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Prognostic Value of Systemic Inflammatory Markers in Patients with Endometrioid-Type Endometrial Cancer: A Retrospective Analysis

Görkem Ülger, Kasım Akay, Hamza Yıldız, Pelin Aytan et autres

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Is systemic inflammation associated with reduced ovarian reserve in endometriosis? An investigation of anti‐Müllerian hormone and inflammatory markers

Görkem Ülger, Hamza Yıldız, Kasım Akay, Ali Yıldızbakan et autres

OBJECTIVE: To examine the correlation between levels of anti-Müllerian hormone (AMH)-which serves as an indicator of ovarian reserve-and inflammation markers in women with endometriomas. METHODS: This retrospective investigation involved 91 women with surgically verified endometriomas. Data on demographics, endometriosis features, and serum …

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A New Marker for the Diagnosis of Acute Pelvic Inflammatory Disease: Immature Granulocyte

Pelin Aytan, Şevki Göksun Gökulu, Hüseyin Durukan, Seyran Bozkurt-Babus et autres

BACKGROUND: The goal is to assess the role of immature granulocytes (IG) in the diagnosis of acute pelvic-inflammatory-disease (PID) and to determine whether they are useful for discriminating mild/moderate and severe PID. METHODS: Patients admitted with the diagnosis of acute PID were …