Total Pectoral Muscle Area and Prognostic Nutritional Index Provide Complementary Prognostic Information for Patients Hospitalized with HFmrEF/HFrEF
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Le résumé fourni par la source
Background: Skeletal muscle depletion and malnutrition are common in heart failure (HF) and are associated with poor outcomes. Whether imaging-derived skeletal muscle reserve and laboratory-based nutritional indices provide complementary prognostic information remains unclear. We evaluated the prognostic value of total pectoral muscle area (TPMA), Prognostic Nutritional Index (PNI), and Controlling Nutritional Status (CONUT) scores in patients hospitalized with HFmrEF/HFrEF. Methods: In this retrospective single-center study, consecutive patients hospitalized with decompensated HF between 2017 and 2025 who underwent thoracic computed tomography were included. TPMA was measured at the T4 level. Nutritional status was assessed using PNI and CONUT. Receiver operating characteristic analysis, Kaplan–Meier analysis, Spearman correlation, and Cox regression were used to evaluate long-term all-cause mortality. Results: A total of 138 patients (median age 66 years; 35.5% women) were included. During a median follow-up of 34.4 months, 87 patients (63.0%) died. Non-survivors had lower TPMA (2589 vs. 3012 mm2, p = 0.002) and PNI (46.0 ± 5.5 vs. 50.2 ± 7.2, p < 0.001). TPMA (AUC 0.661, p = 0.001) and PNI (AUC 0.663, p = 0.001), but not CONUT (AUC 0.561, p = 0.226), predicted mortality. TPMA correlated modestly with PNI (ρ = 0.325, p < 0.001). Low TPMA (<3000 mm2; HR 1.911, p = 0.018), higher BNP (HR 1.024 per 100 pg/mL, p = 0.014), and lower PNI (HR 0.956, p = 0.024) independently predicted mortality. Conclusions: Reduced TPMA and lower PNI were independently associated with long-term mortality in hospitalized patients with HFmrEF/HFrEF. Their modest correlation suggests that they may capture partly distinct aspects of systemic impairment; however, the incremental prognostic value of their combined assessment requires further evaluation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Total Pectoral Muscle Area and Prognostic Nutritional Index Provide Complementary Prognostic Information for Patients Hospitalized with HFmrEF/HFrEF
- Date Crossref
- 29/08/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Bursa Uludağ Üni̇versi̇tesi̇ pays non établi dans la noticeUniversité ou école supérieure
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Bursa Technical University pays non établi dans la noticeUniversité ou école supérieure
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Sağlık Bilimleri Üniversitesi pays non établi dans la noticeUniversité ou école supérieure
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University of Health Sciences Antigua Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Ordu University pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
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Unye State Hospital Department of Cardiology pays non établi dans la noticeÉtablissement de santé
Bursa Uludağ Üni̇versi̇tesi̇, Bursa Technical University et Sağlık Bilimleri Üniversitesi, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.