Accès ouvert
2026
erratum
OpenAlex
Manasi Ratnaparkhe, John K.L. Wong, Pei‐Chi Wei, Mario Hlevnjak et autres
In the version of this article initially published, due to a figure preparation mistake, in Fig. 5a, bottom row of NSC gTP53 gLIG4 , second-to-last image on right, the image presented was incorrect. Due to the age of the article, the figure …
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Accès ouvert
2025
erratum
OpenAlex
Petr Smirnov, Moritz J. Przybilla, Milena Simović, R. Gonzalo Parra et autres
In this article the funding from ‘German Federal Ministry of Education and Research’ was omitted. The original article has been updated.
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Accès ouvert
2024
article
OpenAlex
Petr Smirnov, Moritz J. Przybilla, Milena Simović, R. Gonzalo Parra et autres
Chromothripsis is a frequent form of genome instability, whereby a presumably single catastrophic event generates extensive genomic rearrangements of one or multiple chromosome(s). However, little is known about the heterogeneity of chromothripsis across different clones from the same tumour, as well as …
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Accès ouvert
2022
article
OpenAlex
Mohammad Jaber, Ahmed Radwan, Netanel Loyfer, Mufeed Abdeen et autres
Following fertilization, it is only at the 32-64-cell stage when a clear segregation between cells of the inner cell mass and trophectoderm is observed, suggesting a 'T'-shaped model of specification. Here, we examine whether the acquisition of these two states in vitro, …
il, de
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Accès ouvert
2022
article
OpenAlex
Umar Khalid, Milena Simović, Linda Hammann, Murat Iskar et autres
Chromothripsis is a form of genomic instability characterized by the occurrence of tens to hundreds of clustered DNA double-strand breaks in a one-off catastrophic event. Rearrangements associated with chromothripsis are detectable in numerous tumor entities and linked with poor prognosis in some …
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Accès ouvert
2021
preprint
OpenAlex
Rodrigo Parra, Moritz J. Przybilla, Milena Simović, Hana Sušak et autres
ABSTRACT Chromothripsis is a form of genome instability, whereby a presumably single catastrophic event generates extensive genomic rearrangements of one or few chromosome(s). However, little is known about the heterogeneity of chromothripsis across different clones from the same tumor, as well as …
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Accès ouvert
2021
article
OpenAlex
Thorsten Kolb, Aurélie Ernst
Chromothripsis is a form of genomic instability that was shown to play a major role in cancer. Beyond cancer, this type of catastrophic event is also involved in germline structural variation, genome mosaicism in somatic tissues, infertility, mental retardation, congenital malformations and …
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Accès ouvert
2021
preprint
OpenAlex
Umar Khalid, Milena Simović, Murat Iskar, John KL Wong et autres
ABSTRACT Chromothripsis is a form of genomic instability characterized by the occurrence of tens to hundreds of clustered DNA double-strand breaks in a one-off catastrophic event. Rearrangements associated with chromothripsis are detectable in numerous tumor entities and linked with poor prognosis in …
de, nl
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Accès ouvert
2021
article
OpenAlex
Natalia Voronina, Christian Aichmüller, Thorsten Kolb, Andrey Korshunov et autres
Abstract Adult pilocytic astrocytomas (PAs) have been regarded as indistinguishable from pediatric PAs in terms of genome-wide expression and methylation patterns. It has been unclear whether adult PAs arise early in life and remain asymptomatic until adulthood, or whether they develop during …
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Accès ouvert
2020
preprint
OpenAlex
Mohammad Jaber, Ahmed Radwan, Netanel Loyfer, Mufeed Abdeen et autres
Following fertilization, totipotent cells divide to generate two compartments in the early embryo: the inner cell mass (ICM) and trophectoderm (TE). It is only at the 32-64 -cell stage when a clear segregation between the two cell-types is observed, suggesting a ‘T’-shaped …
il, de
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Accès ouvert
2020
article
OpenAlex
Thorsten Kolb, Umar Khalid, Milena Simović, Manasi Ratnaparkhe et autres
In vitro assays for clustered DNA lesions will facilitate the analysis of the mechanisms underlying complex genome rearrangements such as chromothripsis, including the recruitment of repair factors to sites of DNA double-strand breaks (DSBs). We present a novel method generating localized DNA …
de, il, us
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Accès ouvert
2020
preprint
OpenAlex
Thorsten Kolb, Umar Khalid, Milena Simović, Manasi Ratnaparkhe et autres
ABSTRACT In vitro assays for clustered DNA lesions will facilitate the analysis of the mechanisms underlying complex genome rearrangements such as chromothripsis, including the recruitment of repair factors to sites of DNA double-strand breaks. We present a novel method generating localized DNA …
de
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