Seble G. Negatu

Acute Paternal Immune Activation Shapes Embryonic Development and Protects Offspring from Viral Infection

Taylor Miller-Ensminger, Ariana D. Campbell, Elizabeth A. Kennedy, Madeline N Lamonica et autres

The evolutionary arms race between host and pathogen is traditionally framed as a multigenerational paradigm, where beneficial host immune adaptations accrue in a population over time through DNA sequence variation. If pathogens exposure alters epigenetic information inherited by offspring through paternal gametes, …

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Acute Paternal Immune Activation Shapes Embryonic Development and Protects Offspring from Viral Infection

Taylor Miller-Ensminger, Ariana Campbell Ariana Campbell, Elizabeth Kennedy, Madeline N Lamonica et autres

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Interleukin-27 is antiviral against Zika virus at the maternal-fetal interface

Madeline S. Merlino, Briah Barksdale, Seble G. Negatu, Drake T. Philip et autres

Congenital viral infections can have severe consequences for pregnancy and fetal outcomes. Remarkably, the fetal-derived placenta serves as a robust barrier to infection through meticulous regulation by immune effectors and cytokines. Yet, the regulatory roles of many cytokines remain undefined at the …

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Interleukin 27 (IL-27) is an antiviral cytokine at the maternal-fetal interface 4478

Madeline S. Merlino, Rebecca L. Clements, Briah Barksdale, Seble G. Negatu et autres

Abstract Description During the critical developmental period of pregnancy, there are substantial consequences to infection. The placenta serves as a robust defense against congenital infection through its constitutive expression of antimicrobial cytokines. IL-27 is a highly expressed cytokine in the placenta, however …

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Neutral lipid processing in glia is sexually dimorphic and promotes sleep through diacylglycerol catabolism

Elana S. Pyfrom, Connor Beveridge, Paula Haynes, Vishal A. Kanigicherla et autres

Abstract Sleep is thought to have a protective role in clearing toxic waste from the brain, which may include processing of damaged lipids. We recently showed that blocking endocytosis in glia increases sleep and report here that this block is associated with …

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Interleukin-27 is antiviral at the maternal-fetal interface.

Kellie A. Jurado, Madeline S. Merlino, Briah Barksdale, Seble G. Negatu et autres

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Interleukin-27 is antiviral at the maternal-fetal interface

Madeline S. Merlino, Briah Barksdale, Seble G. Negatu, Rebecca L. Clements et autres

ABSTRACT Congenital viral infections can have severe consequences for pregnancy and fetal outcomes. Remarkably, the fetal-derived placenta serves as a robust barrier to infection through meticulous regulation by immune effectors and a diverse repertoire of cytokines. Yet, the regulatory roles of many …

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Bystander neuronal progenitors in forebrain organoids promote protective antiviral responses

Seble G. Negatu, Christine Vazquez, Carl Bannerman, Kevin R. Amses et autres

Neurotropic viruses are the most common cause of infectious encephalitis and highly target neurons for infection. Our understanding of the intrinsic capacity of neuronal innate immune responses to mediate protective antiviral responses remains incomplete. Here, we evaluated the role of intercellular crosstalk …

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Type I interferon exposure of an implantation-on-a-chip device alters invasive extravillous trophoblast function

Michael K. Simoni, Seble G. Negatu, Ju Young Park, Sneha Mani et autres

Inappropriate type I interferon (IFN) signaling during embryo implantation and placentation is linked to poor pregnancy outcomes. Here, we evaluate the consequence of elevated type I IFN exposure on implantation using a human implantation in an organ-on-a-chip device. We reveal that type …

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Targeting pathogenic interferon-stimulated gene RSAD2 improves pregnancy outcomes in systemic lupus erythematosus models

Seble G. Negatu, Kellie A. Jurado

Excessive type I interferons during pregnancy are associated with poor pregnancy outcomes. Ding et al. 1 demonstrate the pathogenic effects of the interferon-stimulated gene RSAD2 that drives adverse pregnancy outcomes through placental lipid accumulation, and further identify a promising therapeutic candidate. Excessive …

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Neuronal interactions in forebrain organoids lead to protective antiviral responses.

Seble G. Negatu, Christine Vazquez, Carl Bannerman, Kevin R. Amses et autres

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Antiviral immunity within neural stem cells distinguishes Enterovirus-D68 strain differences in forebrain organoids

Christine Vazquez, Seble G. Negatu, Carl Bannerman, Sowmya Sriram et autres

Neural stem cells have intact innate immune responses that protect them from virus infection and cell death. Yet, viruses can antagonize such responses to establish neuropathogenesis. Using a forebrain organoid model system at two developmental time points, we identified that neural stem …

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