Sneha Ramesh Mani

An Intronic SINE at Pou5f1 Links Hormone Signaling to Blastocyst Hatching

Youjia Guo, Hyun Hyung An, Katelyn Toohill, Sneha Ramesh Mani et autres

Before implantation, mammalian embryos must escape from the zona pellucida, a protective glycoprotein coat that surrounds the blastocyst. This process, known as hatching, is essential for uterine attachment and has been viewed largely as a mechanical consequence of blastocyst expansion and zona …

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Interleukin-27 is antiviral against Zika virus at the maternal-fetal interface

Madeline S. Merlino, Briah Barksdale, Seble G. Negatu, Drake T. Philip et autres

Congenital viral infections can have severe consequences for pregnancy and fetal outcomes. Remarkably, the fetal-derived placenta serves as a robust barrier to infection through meticulous regulation by immune effectors and cytokines. Yet, the regulatory roles of many cytokines remain undefined at the …

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Child Loss and Cognitive Health Among Older Adults

Sneha Ramesh Mani, Muqi Guo, Lindsay C. Kobayashi, Alden L. Gross

Abstract The loss of a child, a severe life adversity, is associated with long-term health risks for parents, including increased mortality, cardiovascular diseases, and mental health issues. However, its potential impact on later-life cognitive health remains understudied. We examine the association between …

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A Simulation Approach to Evaluate Pre-Enrollment Survival Bias in Cross-National Aging Epidemiology Research

Ryan M. Andrews, Kelvin Pengyuan Zhang, Alden L. Gross, Sneha Ramesh Mani et autres

Abstract Selection bias caused by collider stratification can distort the estimated effects of exposures on outcomes. As a specific type of selection bias, pre-enrollment survival bias is especially salient in aging research because differential mortality in older populations can yield study samples …

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Interleukin 27 (IL-27) is an antiviral cytokine at the maternal-fetal interface 4478

Madeline S. Merlino, Rebecca L. Clements, Briah Barksdale, Seble G. Negatu et autres

Abstract Description During the critical developmental period of pregnancy, there are substantial consequences to infection. The placenta serves as a robust defense against congenital infection through its constitutive expression of antimicrobial cytokines. IL-27 is a highly expressed cytokine in the placenta, however …

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Microfluidic organ-on-chip device: a unique platform for investigating implantation and placentation

Sneha Ramesh Mani, Se‐Jeong Kim, Rosemary Flock, Dongeun Huh et autres

Disruption of critical processes during early placentation is associated with several pregnancy disorders, leading to high rates of morbidity and mortality globally. However, we are unable to detect or modify the course of these disorders because the fundamental mechanisms underlying their development …

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Interleukin-27 is antiviral at the maternal-fetal interface.

Kellie A. Jurado, Madeline S. Merlino, Briah Barksdale, Seble G. Negatu et autres

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Interleukin-27 is antiviral at the maternal-fetal interface

Madeline S. Merlino, Briah Barksdale, Seble G. Negatu, Rebecca L. Clements et autres

ABSTRACT Congenital viral infections can have severe consequences for pregnancy and fetal outcomes. Remarkably, the fetal-derived placenta serves as a robust barrier to infection through meticulous regulation by immune effectors and a diverse repertoire of cytokines. Yet, the regulatory roles of many …

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Extracellular Vesicles Alter Trophoblast Function in Pregnancies Complicated by COVID‐19

Thea Golden, Sneha Ramesh Mani, Rebecca L. Linn, Rita Leite et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and resulting coronavirus disease (COVID-19) cause placental dysfunction, which increases the risk of adverse pregnancy outcomes. While abnormal placental pathology resulting from COVID-19 is common, direct infection of the placenta is rare. This suggests …

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Type I interferon exposure of an implantation-on-a-chip device alters invasive extravillous trophoblast function

Michael K. Simoni, Seble G. Negatu, Ju Young Park, Sneha Ramesh Mani et autres

Inappropriate type I interferon (IFN) signaling during embryo implantation and placentation is linked to poor pregnancy outcomes. Here, we evaluate the consequence of elevated type I IFN exposure on implantation using a human implantation in an organ-on-a-chip device. We reveal that type …

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Lineage tracing studies suggest that the placenta is not a de novo source of hematopoietic stem cells

Xiaowen Chen, Joanna M. Tober, Martin H. Dominguez, Alan T. Tang et autres

Definitive hematopoietic stem and progenitor cells (HSPCs) arise from a small number of hemogenic endothelial cells (HECs) within the developing embryo. Understanding the origin and ontogeny of HSPCs is of considerable interest and potential therapeutic value. It has been proposed that the …

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LOCAL USE OF POLLUTING COOKING FUELS AND ADULT COGNITIVE HEALTH

Sneha Ramesh Mani, Aashish Gupta, Irma T. Elo

Abstract Scientific understanding of the relationship between environmental hazards and cognitive health at older ages in low- and middle-income countries (LMICs) is poor. Using data from the Longitudinal Aging Study of India and the World Health Organization’s Survey on Global AGEing and …

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