Accès ouvert
2026
article
OpenAlex
Wanjun Qi, Udita Roy, Chunhui Cai, Maikel Acosta‐Zaldívar et autres
Candida albicans is the most common invasive human fungal pathogen. We show that C. albicans thioredoxin reductase, Trr1, is an attractive antifungal target: it is essential at human body temperature, and fungal and human thioredoxin reductases are structurally divergent, predicting high selectivity …
us, il, es
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Accès ouvert
2025
preprint
OpenAlex
Wanjun Qi, Udita Roy, Chunhui Cai, Maikel Acosta‐Zaldívar et autres
Abstract Candida albicans is the most common invasive human fungal pathogen. Each of the currently available 3 antifungal drug classes is limited by toxicities, drug interactions or inadequate penetration of critical tissues. We discovered a connection between C. albicans TOR and thioredoxin …
us, es
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Accès ouvert
2024
article
OpenAlex
María Teresa Ainaga Andrés, Nannette Y. Yount, Maikel Acosta‐Zaldívar, Michael R. Yeaman et autres
Human lactoferrin (hLf) is an innate host defense protein that inhibits microbial H+-ATPases. This protein includes an ancestral structural motif (i.e., γ-core motif) intimately associated with the antimicrobial activity of many natural Cys-rich peptides. Peptides containing a complete γ-core motif from hLf …
es, us
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Accès ouvert
2024
article
OpenAlex
Maikel Acosta‐Zaldívar, Wanjun Qi, Abhishek Kumar Mishra, Udita Roy et autres
Phosphorus is essential in all cells' structural, metabolic and regulatory functions. For fungal cells that import inorganic phosphate (Pi) up a steep concentration gradient, surface Pi transporters are critical capacitators of growth. Fungi must deploy Pi transporters that enable optimal Pi uptake …
us
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Accès ouvert
2024
preprint
OpenAlex
Maikel Acosta‐Zaldívar, Wanjun Qi, Abhishek Kumar Mishra, Udita Roy et autres
Abstract Phosphorus is essential in all cells’ structural, metabolic and regulatory functions. For fungal cells that import inorganic phosphate (Pi) up a steep concentration gradient, surface Pi transporters are critical capacitators of growth. Fungi must deploy Pi transporters that enable optimal Pi …
es, us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
William R. King, Maikel Acosta‐Zaldívar, Wanjun Qi, Nicholas Cherico et autres
ABSTRACT The fungal pathogen Candida albicans must acquire phosphate to colonize, infect, and proliferate in the human host. C. albicans has four inorganic phosphate (P i ) transporters, Pho84 being the major high-affinity transporter; its cells can also use glycerophosphocholine (GPC) as …
us
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Accès ouvert
2022
article
OpenAlex
Wanjun Qi, Maikel Acosta‐Zaldívar, Peter R. Flanagan, Ning-Ning Liu et autres
Whether to commit limited cellular resources toward growth and proliferation, or toward survival and stress responses, is an essential determination made by Target of Rapamycin Complex 1 (TORC1) for a eukaryotic cell in response to favorable or adverse conditions. Loss of TORC1 …
us, ie, es
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Accès ouvert
2022
article
OpenAlex
Patricia Ellen Davenport, Hsuan‐Hao Fan, Emily Nolton, Henry A. Feldman et autres
BACKGROUND: Platelet transfusions (PTxs) are often given to septic preterm neonates at high platelet count thresholds in an attempt to reduce bleeding risk. However, the largest randomized controlled trial (RCT) of neonatal transfusion thresholds found higher mortality and/or major bleeding in infants …
us
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Accès ouvert
2021
article
OpenAlex
Maikel Acosta‐Zaldívar, Wanjun Qi, Ning-Ning Liu, Joann Diray‐Arce et autres
The Candida albicans high-affinity phosphate transporter Pho84 is required for normal Target of Rapamycin signaling, oxidative stress resistance and virulence of this fungal pathogen. It also contributes to C. albicans’ tolerance of two antifungal drug classes, polyenes and echinocandins. Echinocandins inhibit biosynthesis …
us, cn, gb, il
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Accès ouvert
2021
article
OpenAlex
Xionghui Ding, Hiroto Kambara, Rongxia Guo, Apurva Kanneganti et autres
Candida albicans is the most common cause of fungal sepsis. Inhibition of inflammasome activity confers resistance to polymicrobial and LPS-induced sepsis; however, inflammasome signaling appears to protect against C. albicans infection, so inflammasome inhibitors are not clinically useful for candidiasis. Here we …
us, cn
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2021
conference-abstract
OpenAlex
Patricia Ellen Davenport, Hsuan‐Hao Fan, Emily Nolton, Henry A. Feldman et autres
Abstract Thrombocytopenia affects 18-35% of all neonates in the Neonatal Intensive Care Unit and ~70% of those born extremely prematurely, with sepsis being a frequent cause. Platelet transfusions (PTx) are frequently given to septic preterm neonates at higher platelet count (PC) thresholds …
us
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Accès ouvert
2020
article
OpenAlex
Ángel L. Álvarez, Alberto García-Manso, Kevin P. Dalton, José Manuel Martín-Alonso et autres
Most caliciviruses are refractory to replication in cell culture and only a few members of the family propagate in vitro. Rabbit vesivirus (RaV) is unique due to its ability to grow to high titers in several animal and human cell lines. This …
es
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