María Teresa Ainaga Andrés

Ovotransferrin and Its γ-Core-Containing Peptides Impair Pma1-Dependent Proton Homeostasis in Candida albicans

Victoria Antuña, Patricia Fierro, José F. Fierro, Ángel L. Álvarez et autres

Ovotransferrin (OvoTf) is an iron-binding glycoprotein of avian innate immunity with antimicrobial activity, but its antifungal mechanism remains incompletely understood. We examined the candidacidal activity of OvoTf and two derived γ-core-containing peptides, kaliocin-3 (Kal-3) and kaliocin-4 (Kal-4), against Candida albicans. All three …

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Cascading damage to Candida albicans cells through thioredoxin reductase loss

Wanjun Qi, Udita Roy, Chunhui Cai, Maikel Acosta‐Zaldívar et autres

Candida albicans is the most common invasive human fungal pathogen. We show that C. albicans thioredoxin reductase, Trr1, is an attractive antifungal target: it is essential at human body temperature, and fungal and human thioredoxin reductases are structurally divergent, predicting high selectivity …

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Non-Thermal Milk Decontamination by Ionic Modulation: A Deionization-Based Alternative to Pasteurization

María Teresa Ainaga Andrés, Jessica González-Seisdedos, Victoria Lobo Antuña, José F. Fierro

The dairy industry requires effective non-thermal processing strategies capable of ensuring microbial safety while preserving the nutritional and bioactive quality of milk. This study describes a novel milk decontamination approach based on selective ionic removal by dialysis, resulting in a controlled reduction …

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Metabolic pathway competition sensitizes thioredoxin reductase-depleted Candida albicans to cell wall stress and antifungals

Wanjun Qi, Udita Roy, Chunhui Cai, Maikel Acosta‐Zaldívar et autres

Abstract Candida albicans is the most common invasive human fungal pathogen. Each of the currently available 3 antifungal drug classes is limited by toxicities, drug interactions or inadequate penetration of critical tissues. We discovered a connection between C. albicans TOR and thioredoxin …

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The Archetypal Gamma-Core Motif of Antimicrobial Cys-Rich Peptides Inhibits H+-ATPases in Target Pathogens

María Teresa Ainaga Andrés, Nannette Y. Yount, Maikel Acosta‐Zaldívar, Michael R. Yeaman et autres

Human lactoferrin (hLf) is an innate host defense protein that inhibits microbial H+-ATPases. This protein includes an ancestral structural motif (i.e., γ-core motif) intimately associated with the antimicrobial activity of many natural Cys-rich peptides. Peptides containing a complete γ-core motif from hLf …

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The Antimicrobial Activity of Human Defensins at Physiological Non-Permeabilizing Concentrations Is Caused by the Inhibition of the Plasma Membrane H+-ATPases

María Teresa Ainaga Andrés, Patricia Fierro, Victoria Lobo Antuña, José F. Fierro

Human defensins are cysteine-rich peptides (Cys-rich peptides) of the innate immune system. Defensins contain an ancestral structural motif (i.e., γ-core motif) associated with the antimicrobial activity of natural Cys-rich peptides. In this study, low concentrations of human α- and β-defensins showed microbicidal …

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Stress- and metabolic responses of Candida albicans require Tor1 kinase N-terminal HEAT repeats

Wanjun Qi, Maikel Acosta‐Zaldívar, Peter R. Flanagan, Ning-Ning Liu et autres

Whether to commit limited cellular resources toward growth and proliferation, or toward survival and stress responses, is an essential determination made by Target of Rapamycin Complex 1 (TORC1) for a eukaryotic cell in response to favorable or adverse conditions. Loss of TORC1 …

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A review on lactoferrin as a proton pump inhibitor

Cátia Santos‐Pereira, María Teresa Ainaga Andrés, José F. Fierro, Lígia R. Rodrigues et autres

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Stress- and metabolic responses of Candida albicans require Tor1 kinase N-terminal HEAT repeats

Wanjun Qi, Maikel Acosta‐Zaldivar, Peter R. Flanagan, Ning-Ning Liu et autres

Abstract Whether to commit limited cellular resources toward growth and proliferation, or toward survival and stress responses, is an essential determination made by Target of Rapamycin Complex 1 (TORC1) for a eukaryotic cell in response to favorable or adverse conditions. Loss of …

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Lactoferrin perturbs lipid rafts and requires integrity of Pma1p-lipid rafts association to exert its antifungal activity against Saccharomyces cerevisiae

Cátia Santos‐Pereira, María Teresa Ainaga Andrés, Susana Rodrigues Chaves, José F. Fierro et autres

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Cytosolic Acidification Is the First Transduction Signal of Lactoferrin-Induced Regulated Cell Death Pathway

María Teresa Ainaga Andrés, Maikel Acosta‐Zaldívar, Jessica González-Seisdedos, José F. Fierro

In yeast, we reported the critical role of K+-efflux for the progress of the regulated cell death (RCD) induced by human lactoferrin (hLf), an antimicrobial protein of the innate immune system that blocks Pma1p H+-ATPase. In the present study, the K+ channel …

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Differential effects on neurotransmission and behavior in mouse models overexpressing human wild-type or mutated α-synuclein or mutated LRRK2 protein

Rubén Pavia-Collado, Diana Alarcón-Arís, Vincenzo Coppola, Esther Ruiz‐Bronchal et autres

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