Jun Feng

Fabrication Technologies for Soft, Multimaterial Optical Fibers for In Vivo Diagnostics and Phototherapy, With a Focus on Extrusion Printing

Zahra Kafrashian, Jun Feng, Aránzazu del Campo

ABSTRACT Multimaterial optical fibers provide a versatile platform for integrating diverse functionalities—such as waveguiding, side emission, sensing, and actuation—into a single filament. Although traditional multimaterial fibers have primarily been fabricated from rigid materials such as silica and thermoplastics for optoelectronic applications, recent …

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Redox-Responsive Self-Assembled Amphiphilic Nanosheets from Polyglycerol Sulfate–Lipoic Acid Copolymers for Targeted Cancer Drug Delivery

Taylor M. Page, Kai Ludwig, Muhammad Usman Haider, Elisa Quaas et autres

High Resolution Image Download MS PowerPoint Slide Targeted drug delivery systems that are stimuli-responsive offer great potential for enhancing the therapeutic activity of drugs, decreasing off-target effects, and improving bioavailability. This proof-of-concept study introduces an amphiphilic drug delivery system (DDS) capable of …

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256 Preclinical development of AB-3028, a logic-gated engineered CAR T cell product intended for the treatment of metastatic castration-resistant prostate cancer (mCRPC)

Suchismita Mohanty, Hongruo Yun, Alma Gomez, Jeremy Chen et autres

Background Metastatic castration-resistant prostate cancer (mCRPC) remains a disease with low long-term survival, and while new modalities are showing progress, there is still an unmet need for durable responses in advanced mCRPC patients. While CAR T cells have shown remarkable success in …

Immune cells as mediators in lipids-colorectal cancer risk: A Mendelian randomization study

Xu Zhang, Xuchu Duan, Liping Wang, Jian Zhang et autres

The occurrence and progression of colorectal cancer (CRC) are closely associated with abnormal lipid metabolism and immune regulation in the tumor microenvironment. Lipids are not only essential components of cell membranes but also influence CRC progression by modulating signaling pathways and inflammatory …

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A Robust Heparin‐Mimicking Polyglycerol‐Based Coating for Blood‐Contacting Devices with Long‐Term Hemocompatibility and Preliminary Anti‐Inflammatory Properties

Kunpeng Liu, Philip Nickl, Jun Feng, Rainer Haag

Blood-contacting medical devices play a crucial role in clinical interventions, but their susceptibility to thrombosis and inflammation poses serious risks to treatment outcomes and patient safety. This study presents a novel coating that combines dendritic polyglycerol amine (dPGA), dendritic polyglycerol aldehyde (dPG-CHO), …

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Dual-Dynamic Covalently Cross-Linked Polyglycerol Hydrogels for Tumor Spheroid Culture

Jun Feng, Polina F. Ponomareva, Kunpeng Liu, Chuanxiong Nie et autres

Advancing cancer research depends significantly on developing accurate and reliable models that can replicate the complex tumor microenvironment. Tumor spheroids─three-dimensional clusters of cancer cells─have become crucial tools for this purpose. The overarching goal of tumor spheroid culture is to develop biomaterials that …

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Author response for "Photo-regulated disulfide crosslinking: a versatile approach to construct mucus-inspired hydrogels"

Rui Chen, Krishnendu Das, Jun Feng, Boonya Thongrom et autres

Photo-regulated disulfide crosslinking: a versatile approach to construct mucus-inspired hydrogels

Rui Chen, Krishnendu Das, Jun Feng, Boonya Thongrom et autres

We report a photo-regulated disulfide crosslinking strategy to construct mucus-mimetic hydrogels. Light-responsive 1,2-dithiolane on linear polyglycerol sulfate (lPGS) enables dynamic crosslinking and forms a biohybrid hydrogel with native mucin.

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Abstract 6319: Characterization of AB-1015 logic-gated CAR induction (ON kinetics), receptor turnover (OFF kinetics), and logic gate sensitivity to ALPG/P and MSLN

Xinyan Tang, Marvin Chew, Rakesh Sudhakar, Hongruo Yun et autres

Abstract CAR T cell activity in solid tumors is limited, in part, by off-tumor toxicity. To address this obstacle, AB-1015 contains an “AND” logic gate, consisting of a priming receptor (PrimeR) and an inducible chimeric antigen receptor (CAR) that is upregulated by …

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Abstract B080: AB-1015, an Integrated Circuit T (ICT) cell therapy containing an ALPG/MSLN logic gate and FAS/PTPN2 shRNA-miR, for the treatment of ovarian cancer

Jun Feng, Jasper Z. Williams, Hongruo Yun, Dina Polyak et autres

Abstract CAR T cell activity in solid tumors is limited by off-tumor toxicity and functional suppression from the tumor microenvironment (TME). To address these challenges, we have developed AB-1015, an autologous ICT cell product intended for use in ovarian cancer. AB-1015 incorporates …

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Abstract B070: Logic-gated CAR T cell product AB-1015 response to ovarian cancer models with heterogeneous levels of ALPG/P antigen

Dina Polyak, Erik Beckman, Preethi Bala Balakrishnan, Hongruo Yun et autres

Abstract In solid tumors, CAR T cell efficacy is limited by on-target off-tumor toxicity, as well as functional suppression by the tumor microenvironment (TME). AB-1015 is an integrated circuit T cell (ICT cell) developed for use in ovarian cancer. The AB-1015 transgene …

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Linoleic Acid and Heat Synergistically Promote the Aggregation of Soybean Proteins and its Molecular Interaction Mechanism

Xiaohua Liu, Jun Feng, Junkai Wang, Xiangmin Li et autres

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