Elisa Quaas

Fluorination as a Molecular Design Parameter for Programming Peptide Nanocarriers

Maurizio Iannuzzi, Holly Fiedler, Kilian Haoues, Suvrat Chowdhary et autres

Peptide-based nanocarriers offer unique opportunities for programmable self-assembly (SA), yet rational design strategies that couple structural control with biological function remain limited. In particular, fluoropeptides have been largely inaccessible as modular building blocks until the recent availability of enantiomerically pure fluorinated amino …

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Poly(Glycerol‐Sulfur) as a Functional Sustainable Nanomaterial: Synthesized by Anionic Ring Opening Polymerization of Elemental Sulfur

Paraskevi S. Stergiou, Mariam Cherri, Philip Nickl, Elisa Quaas et autres

ABSTRACT Elemental sulfur is an abundant by‐product of the petroleum industry, yet its controlled incorporation into functional polymer architectures remains challenging. Here, we report a one‐pot, moderate‐temperature (120°C) anionic copolymerization of elemental sulfur (S 8 ) with glycidol to produce hyperbranched poly(glycerol‐sulfur)s …

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Two-dimensional fluorinated nanomaterials for fast and selective detection of PFAS at subpicomolar concentrations

Reza Ghanbari, Javier Camargo Díaz, Maryam Salahvarzi, Philip Nickl et autres

Two-dimensional fluorinated nanomaterials (2DFs) possess tunable band structures and unique optoelectronic properties, but their controlled synthesis remains challenging due to the lack of mild and scalable methods. Here, we report a gram-scale, room temperature synthesis of ultra-thin 2DF sheets (1–2 nm) with …

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Fluorination as a Molecular Design Parameter for Programming Peptide Nanocarriers

Maurizio Iannuzzi, Holly Fiedler, Kilian Haoues, Suvrat Chowdhary et autres

Peptide-based nanocarriers offer unique opportunities for programmable self-assembly, yet rational design strategies that couple structural control with biological function remain limited. In particular, fluoropeptides have been largely inaccessible as modular building blocks until the recent availability of enantiomerically pure fluorinated amino acids …

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Sulfation of thiol–maleimide crosslinked hydrogels modulates material properties and cell biocompatibility

Lasse Riediger, Lei Wang, Peer Nölte, Cosmin Butnarasu et autres

Sulfation has become a critical but still underexplored factor influencing hydrogel properties and regulating cell behaviour. In this study, a thiol–maleimide crosslinked hydrogel system based on a poly( N -isopropylacrylamide) (pNIPAM) copolymer and dendritic polyglycerol (dPG) was developed to systematically investigate how …

Poly(Glycerol-Sulfur) as a Functional Sustainable Nanomaterial: Synthesized by Anionic Ring Opening Polymerization of Elemental Sulfur

Paraskevi S. Stergiou, Mariam Cherri, Philip Nickl, Elisa Quaas et autres

Elemental sulfur is an abundant by-product of the petroleum industry, yet its controlled incorporation into functional polymer architectures remains challenging. Here, we report a one-pot, moderate-temperature (120°C) anionic copolymerization of elemental sulfur (S8) with glycidol to produce hyperbranched poly(glycerol-sulfur)s with tunable molecular …

Sulfation of thiol–maleimide crosslinked hydrogels modulates material properties and cell biocompatibility

Lasse Riediger, Lei Wang, Peer Nölte, Cosmin Butnarasu et autres

Sulfation of thermoresponsive pNIPAM–dPG hydrogels modulates pore size, stiffness and molecular transport, supporting cell-type-specific viability and spheroid formation in 3D culture.

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Author response for "Sulfation of Thiol-Maleimide Crosslinked Hydrogel Modulates Material Properties and Cell Biocompatibility"

Lasse Riediger, Lei Wang, Peer Nölte, Cosmin Butnarasu et autres

Redox-Responsive Self-Assembled Amphiphilic Nanosheets from Polyglycerol Sulfate–Lipoic Acid Copolymers for Targeted Cancer Drug Delivery

Taylor M. Page, Kai Ludwig, Muhammad Usman Haider, Elisa Quaas et autres

High Resolution Image Download MS PowerPoint Slide Targeted drug delivery systems that are stimuli-responsive offer great potential for enhancing the therapeutic activity of drugs, decreasing off-target effects, and improving bioavailability. This proof-of-concept study introduces an amphiphilic drug delivery system (DDS) capable of …

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Redox-Responsive Self-Assembled Amphiphilic Nanosheets from Polyglycerol Sulfate–Lipoic Acid Copolymers for Targeted Cancer Drug Delivery

Taylor M. Page, Kai Ludwig, Muhammad Usman Haider, Elisa Quaas et autres

Targeted drug delivery systems that are stimuli-responsive offer great potential for enhancing the therapeutic activity of drugs, decreasing off-target effects, and improving bioavailability. This proof-of-concept study introduces an amphiphilic drug delivery system (DDS) capable of loading hydrophobic cargo. Elevated glutathione (GSH) levels, …

Sulfonium‐Based Antimicrobial Block Copolymers: Influence of Hydrophobicity on Biological Activity and Antibiotic Synergy

Sidra Kanwal, Otto Staudhammer, Umer Bin Abdul Aziz, Elisa Quaas et autres

Antimicrobial polymers (AMP) are promising therapeutics to target bacterial pathogens. Sulfonium-based AMPs offer a good balance between high antimicrobial activity and low cytotoxicity. Currently, sulfonium groups are mostly incorporated into random copolymers that combine these cations with hydrophobic and neutral hydrophilic groups. …

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Multi‐Responsive Nanogels Based on Sulfoxide Polymethacrylates for Biomedical Applications

Clara López‐Iglesias, Sidra Kanwal, Elisa Quaas, Daniel Klinger

ABSTRACT Nanogels for biomedical applications require polymeric building blocks that show high hydrophilicity and (thermo‐)responsive properties without immune response risks. Polysulfoxides offer these advantages but have not yet been translated to 3‐dimensional colloidal materials. To examine their potential as alternatives to established …

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