Ubaldo Familiari

Patient and Context Factors in the Adoption of Active Surveillance for Low-Risk Prostate Cancer

Giovannino Ciccone, Stefano De Luca, Marco Oderda, F. Muñoz et autres

Importance: Although active surveillance for patients with low-risk prostate cancer (LRPC) has been recommended for years, its adoption at the population level is often limited. Objective: To make active surveillance available for patients with LRPC using a research framework and to compare …

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Multiomic analysis of HER2-enriched and AR-positive breast carcinoma with apocrine differentiation and an oligometastatic course: a case report

Brando Poggiali, Agostino Ponzetti, Marica Malerba, Fabio Landuzzi et autres

Breast carcinoma is the most prevalent cancer among women globally. It has variable clinical courses depending on the stage and clinical-biological features. This case report describes a 56-year-old female with invasive breast cancer without estrogen or progesterone receptor expression, with apocrine differentiation, …

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Interleukin-2 Receptor Alpha Chain, Also Called CD25, Is a Potential Target in Acute Lymphoblastic Leukemia

Giovanna Carrà, Antonio Cartellà, Beatrice Maffeo, Paola Circosta et autres

Background: Acute lymphoblastic leukemia (ALL) is a molecularly heterogeneous disease originating from clonal proliferation of precursor B-lineage cells. In adults, ALL diagnosis is still associated with a dismal prognosis due to the lack of specific targeted therapies. This study was designed to …

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RNA Sequencing Analysis in Primary Mediastinal B Cell Lymphoma: Identification of Different Gene Expression Related to Chemoresistance

Guido Parvis, Danny Incarnato, Davide Torti, Ubaldo Familiari et autres

Background: Primary mediastinal large B cell lymphoma (PMLBCL) is a rare subtype of non-Hodgkin lymphoma mostly diagnosed in young women and is currently recognized as a distinct clinical and biological entity. First line therapy with R-CHOP allows to achieve good remission rates …

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Pure red cell aplasia and amegakaryocytic thrombocytopenia in thymoma: The uncharted territory

Matteo Dragani, Giacomo Andreani, Ubaldo Familiari, Valerio Marci et autres

Association between thymoma and pure red cell aplasia is already well-documented in literature whereas acquired amegakaryocytic thrombocytopenia is rarely reported. In this case, even with the addition of eltrombopag to standard immunosuppression, the cytopenias did not improve, probably due to the lack …

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Bone marrow granulomatosis: two case reports

Giacomo Andreani, Alessandro Morotti, Matteo Dragani, Francesca Caciolli et autres

Bone marrow granulomatosis is not a common finding and remains a diagnostic challenge. Here below we report two bizarre but not so rare cases of bone marrow granulomatosis: bone marrow involvement by Mycobacterium avium-intracellulare and reaction to intravesical administration of Bacillus Calmette-Guérin …

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Mandibular and cheek swelling revealing the diagnosis of localized amyloidosis

Matteo Val, Roberto Luiz Marino, Tommasina Guglielmelli, Ubaldo Familiari et autres

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your …

Detection and management of retroperitoneal cystic lesions: A case report and review of the literature

Alessandro Morotti, Marco Busso, Maria Consiglio Barozzino, Paola Cinardo et autres

The identification of cystic lesions within the retroperitoneal space is a rare event that poses clinicians the challenge of a difficult diagnosis and disease management. Retroperitoneal cystic lesions account for a group of lesions that range from common benign lesions (e.g., lymphoceles …

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Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones

Giovanna Carrà, Cristina Panuzzo, Davide Torti, Guido Parvis et autres

// Giovanna Carrà 1 , Cristina Panuzzo 1 , Davide Torti 1,2 , Guido Parvis 2,3 , Sabrina Crivellaro 1 , Ubaldo Familiari 4 , Marco Volante 4,5 , Deborah Morena 5 , Marcello Francesco Lingua 5 , Mara Brancaccio 6 , …

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ROCK AS THERAPEUTICAL TARGET FOR MORGANA LOW CML

Stefania Rocca, Augusta Di Savino, Cristina Panuzzo, Ubaldo Familiari et autres

Background:Atypical chronic myeloid leukemia (aCML) is an haematological neoplasm characterized by a median overall survival of 12.4 months. The standard treatments for aCML patients are chemotherapeutic drugs. However, these treatments result inefficient in inducing remission from the pathology. Recently we demonstrated that …

INHIBITION OF USP7 INDUCES SELECTIVE CANCER CELL DEATH IN CHRONIC LYMPHOCYTIC LEUKEMIA THROUGH PTEN AND INDEPENDENTLY FROM P53 STATUS

Giovanna Carrà, Cristina Panuzzo, Sabrina Crivellaro, Davide Torti et autres

Conclusions: Our global protein expression database for CLL cells is thus the most complete database of its type.By combining advanced computational biology to relate protein expression to whole genome sequencing data, the database will provide a framework for elucidating the effect of …

Small bowel cancer diagnosis: role of nuclear magnetic resonance

Alessandro Morotti, Dario Gned, Leonardo Di Martino, Claudia Vaccheris et autres

The diagnosis of small intestine tumors is challenging. Even in the era of modern medicine, standard approaches including echography, computed tomography-scan and conventional endoscopy are unable to reveal small bowel lesions. Video-capsule has substantially improved the evaluation of small bowel; however this …

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