INHIBITION OF USP7 INDUCES SELECTIVE CANCER CELL DEATH IN CHRONIC LYMPHOCYTIC LEUKEMIA THROUGH PTEN AND INDEPENDENTLY FROM P53 STATUS

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Conclusions: Our global protein expression database for CLL cells is thus the most complete database of its type.By combining advanced computational biology to relate protein expression to whole genome sequencing data, the database will provide a framework for elucidating the effect of genomic alterations on protein expression.The construction of this comprehensive CLL database also provides the platform for applying SWATH/MS-based analysis of individual patient samples to identify novel drug targets and predictive biomarkers of disease progression and treatment response. E1023

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.