Sabrina Crivellaro

Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones

Giovanna Carrà, Cristina Panuzzo, Davide Torti, Guido Eugenio Parvis et autres

// Giovanna Carrà 1 , Cristina Panuzzo 1 , Davide Torti 1,2 , Guido Parvis 2,3 , Sabrina Crivellaro 1 , Ubaldo Familiari 4 , Marco Volante 4,5 , Deborah Morena 5 , Marcello Francesco Lingua 5 , Mara Brancaccio 6 , …

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IκB-α: At the crossroad between oncogenic and tumor-suppressive signals

Alessandro Morotti, Sabrina Crivellaro, Cristina Panuzzo, Giovanna Carrà et autres

Nuclear factor κB (NF-κB) is an essential component of tumorigenesis and resistance to cancer treatments. NFKB inhibitor α (IκB-α) acts as a negative regulator of the classical NF-κB pathway through its ability to maintain the presence of NF-κB in the cytoplasm. However, …

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Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex

Giovanna Carrà, Sabrina Crivellaro, Riccardo Taulli, Angelo Guerrasio et autres

TP53 is one of the most frequently-mutated and deleted tumor suppressors in cancer, with a dramatic correlation with dismal prognoses. In addition to genetic inactivation, the p53 protein can be functionally inactivated in cancer, through post-transductional modifications, changes in cellular compartmentalization, and …

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The p53 orbit in chronic myeloid leukemia: time to move to patient care

Alessandro Morotti, Giovanna Carrà, Sabrina Crivellaro

Chronic myeloid leukemia (CML) is the paradigm of precision medicine in cancer. CML was the first disease to be effectively treated with selective drug designed to inhibit the causative BCR-ABL oncoprotein activity. BCR-ABL tyrosine kinase inhibitor (TKI), imatinib, was the first FAD …

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The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia

Giovanna Carrà, Cristina Panuzzo, Sabrina Crivellaro, Deborah Morena et autres

Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) is driven by the p190 breakpoint cluster region (BCR)‑ABL isoform. Although effectively targeted by BCR‑ABL tyrosine kinase inhibitors (TKIs), ALL is associated with a less effective response to TKIs compared with chronic myeloid leukemia. Therefore, …

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Inhibition OF USP7 Induces Selective Cancer Cell Death in Chronic Lymphocytic Leukemia

Giovanna Carrà, Cristina Panuzzo, Davide Torti, Guido Eugenio Parvis et autres

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Non-Oncogene Addiction to BRD in CLL: from JQ1 Response to Resistence

Giovanna Carrà, Sabrina Crivellaro, Cristina Panuzzo, Deborah Morena et autres

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The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias

Giovanna Carrà, Davide Torti, Sabrina Crivellaro, Cristina Panuzzo et autres

// Giovanna Carrà 1 , Davide Torti 1 , Sabrina Crivellaro 1 , Cristina Panuzzo 1 , Riccardo Taulli 2 , Daniela Cilloni 1 , Angelo Guerrasio 1 , Giuseppe Saglio 1 and Alessandro Morotti 1 1 Department of Clinical and Biological …

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Unleashing the Guardian: The Targetable BCR-ABL/HAUSP/PML/PTEN Network in Chronic Myeloid Leukemia

Alessandro Morotti, Davide Torti, Giovanna Carrà, Cristina Panuzzo et autres

The complete eradication of Chronic Myeloid Leukemia is still challenging even in the era of highly selective and potent BCR-ABL tyrosine kinase inhibitors (TKIs). The 'Achilles heel' of TKI-based CML therapy is the inability of TKI to effectively target CML stem cells. …

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The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase

Sabrina Crivellaro, Giovanna Carrà, Cristina Panuzzo, Riccardo Taulli et autres

BACKGROUND: Chronic Myeloid Leukemia was always referred as a unique cancer due to the apparent independence from tumor suppressors' deletions/mutations in the early stages of the disease. However, it is now well documented that even genetically wild-type tumor suppressors can be involved …

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Mechanisms of p53 Functional De-Regulation: Role of the I.KAPPA.B-.ALPHA./p53 Complex

Giovanna Carrà, Sabrina Crivellaro, Riccardo Taulli, Angelo Guerrasio et autres

INHIBITION OF USP7 INDUCES SELECTIVE CANCER CELL DEATH IN CHRONIC LYMPHOCYTIC LEUKEMIA THROUGH PTEN AND INDEPENDENTLY FROM P53 STATUS

Giovanna Carrà, Cristina Panuzzo, Sabrina Crivellaro, Davide Torti et autres

Conclusions: Our global protein expression database for CLL cells is thus the most complete database of its type.By combining advanced computational biology to relate protein expression to whole genome sequencing data, the database will provide a framework for elucidating the effect of …