Peter Leth Jørgensen

Heterogeneity of the intestinal mononuclear phagocyte compartment in health and inflammatory bowel disease

Thomas M. Fenton, Line Wulff, Venla A. Väänänen, Gareth‐Rhys Jones et autres

Understanding of mononuclear phagocyte (MNP) diversity in the human intestine and the alterations this compartment undergoes in inflammation remains incomplete. Here, we used single-cell RNA sequencing, cellular indexing of trancriptomes and epitopes by sequencing, flow cytometry, and imaging to explore MNP heterogeneity …

gb, dk, se (code pays fourni par la source)

Fibroblast diversity within human gut-associated lymphoid tissues

Urs Mörbe, Fredrik Junghus, Grigorii Nos, Peter Leth Jørgensen et autres

Gut-associated lymphoid tissues (GALT) represent major sites of adaptive immune priming in the intestine, yet our understanding of human GALT diversity and function remains limited. Here, we used single-cell RNA sequencing, flow cytometry, and confocal laser microscopy to map the fibroblast (FB) …

dk, se (code pays fourni par la source)

Circulating Biomarkers of Macrophage Activation in Different Stages of Chronic Pancreatitis

Rasmus Hagn-Meincke, Srdan Novovic, Amer Hadi, Annette Bøjer Jensen et autres

OBJECTIVES: Activation of type M2 macrophages has been implicated in the pathogenesis of chronic pancreatitis (CP). In a clinical pilot study, we investigated blood-based markers of macrophage activation at different stages of CP. MATERIALS AND METHODS: We performed a cross-sectional analysis of …

dk, us, ca (code pays fourni par la source)

Structure and Molecular Mechanism of the Na,K-Pump

Peter Leth Jørgensen

The Na,K-pump is prototype for cation pumps that couple ATP hydrolysis to primary active transport of cations, Na + , K + , Ca 2+ , and H + across cell membranes. In mammalian cells the Na,K-pump is particularly important for the …

Danish Foundation Models

Kenneth Enevoldsen, Lasse Hansen, D. S. Nielsen, Rasmus Arpe Fogh Egebæk et autres

Large language models, sometimes referred to as foundation models, have transformed multiple fields of research. However, smaller languages risk falling behind due to high training costs and small incentives for large companies to train these models. To combat this, the Danish Foundation …

The porcine large intestine contains developmentally distinct submucosal lymphoid clusters and mucosal isolated lymphoid follicles

Peter Leth Jørgensen, Lise Lotte Eriksen, Thomas M. Fenton, Michael Bailey et autres

Gut-associated lymphoid tissues (GALT) serve as key priming sites for intestinal adaptive immune responses. Most of our understanding of GALT function and development arises from studies in mice. However, the diversity, structure and cellular composition of GALT differs markedly between mammalian species …

dk, gb, se (code pays fourni par la source)

Fibroblast-Like Synovial Cell Subsets in Rheumatoid Arthritis

Søren Lomholt, Morten Aagaard Nielsen, M. Aspari, Peter Leth Jørgensen et autres

Fibroblasts like synoviocytes (FLS) play several significant roles in rheumatoid arthritis (RA) pathophysiology. This chapter will describe known roles of FLS in disease initiation, joint inflammation, disease persistence and joint destruction. It will describe the newly characterized subsets of FLS based on …

it (code pays fourni par la source)

Human gut-associated lymphoid tissues (GALT); diversity, structure, and function

Urs Mörbe, Peter Leth Jørgensen, Thomas M. Fenton, Nicole von Burg et autres

dk, gb, se (code pays fourni par la source)

Identification, isolation and analysis of human gut-associated lymphoid tissues

Peter Leth Jørgensen, Thomas M. Fenton, Urs Mörbe, Lene Buhl Riis et autres

dk, se (code pays fourni par la source)

Expanding the Heterogeneity of Human Dendritic Cells in the Intestinal Lamina Propria

Line Wulff, Thomas M. Fenton, Gareth‐Rhys Jones, Julien Vandamme et autres

dk (code pays fourni par la source)

COVID-19 treatment in sub-Saharan Africa: If the best is not available, the available becomes the best

Jan Henk Dubbink, Tiago Branco, Kelfala B.B. Kamara, James Bangura et autres

nl, Sierra Leone, no, pt (code pays fourni par la source)

Immune Profiling of Human Gut-Associated Lymphoid Tissue Identifies a Role for Isolated Lymphoid Follicles in Priming of Region-Specific Immunity

Thomas M. Fenton, Peter Leth Jørgensen, Kristoffer Niss, Samuel J. S. Rubin et autres

dk, us, se (code pays fourni par la source)