Michael Bailey

Association between prior ICU admission for drug overdose and ICU readmission: A retrospective registry-based study

Michael Wu, Ashwin Subramaniam, Ryan Ruiyang Ling, Paul Secombe et autres

Objective: We aimed to investigate patients discharged alive from hospital following an ICU admission for drug overdose and whether exposure of prior overdose-related ICU admission was associated with a future ICU readmission. Design setting participants: This multicentre registry-based study included data from …

au, sg (code pays fourni par la source)

Incidence, Predictors, and Outcomes of Patient-Prosthesis Mismatch After Surgical Aortic Valve Replacement

Y. Wang, T. Robert Vu, Varun Sharma, Lavinia Tran et autres

au (code pays fourni par la source)

Association of Hypercapnic and Nonrespiratory Acidemia With Hospital Mortality in Mechanically Ventilated Patients With Sepsis: A Retrospective Multicenter Cohort Study

Ravindranath Tiruvoipati, Jason Zheng, Sachin Gupta, D. Pilcher et autres

OBJECTIVES: The mortality among patients admitted with sepsis remains high and varies depending on the site of infection. The impact of hypercapnia and acidemia on clinical outcomes in mechanically ventilated patients with sepsis is not well understood. DESIGN: Multicenter, binational, retrospective study …

au (code pays fourni par la source)

Impact of mobilization dose on outcome of critically ill patients receiving mechanical ventilation—a target trial emulation using data from the TEAM trial

A. Serpa Neto, Michael Bailey, Daniel Seller, Alicia Agli et autres

RATIONALE: Variability in the outcomes of mobilization interventions is expected due to their complexity, and one of the post hoc hypotheses for the findings of the TEAM trial is the impact of "dosage" of mobilization on clinical outcomes. OBJECTIVES: The aim of …

au, br, vn, nz, gb, ie, us, de (code pays fourni par la source)

Beyond neutral trials in critical care: embracing statistical alternatives

Ary Serpa Neto, Humphrey G. M. Walker, Alastair Brown, Andrew Udy et autres

Critical care research has long struggled with the challenge of designing clinical trials that produce meaningful and relevant results. A significant proportion of these trials failed to demonstrate statistically significant differences between intervention and control groups.1,2 This issue often stems from limited …

br, au (code pays fourni par la source)

Multimodal Spatial Transcriptomics Reveals the Developing Human Liver Niche at Single-Cell Resolution

Michael Bailey, Michael Leon, Isabella Rosso, Carolyn Sangokoya

Background and Aims: A comprehensive understanding of the liver niche during development provides insights into a unique, naturally occurring multifunctional multicellular environment. We applied spatial transcriptomic and histologic approaches to identify and histologically validate RNA-based markers in human liver tissue during a …

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Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding

Michael C. Reade, Denese C. Marks, Belinda Howe, Michael Bailey et autres

Importance: Liquid-stored platelets have a shelf-life of 5 to 7 days, limiting availability and resulting in wastage. Objective: To assess the effectiveness and safety of dimethyl sulfoxide-cryopreserved platelets, which have a shelf-life of 2 years, as a treatment for cardiac surgery bleeding. …

au, gb, us (code pays fourni par la source)

Cost-Effectiveness of Cryopreserved vs Liquid-Stored Platelets for Managing Surgical Bleeding

Zhomart Orman, Michael C. Reade, Denese C. Marks, Belinda Howe et autres

Importance: Platelet transfusion is critical in managing major bleeding, but access to liquid-stored platelets is limited by their 5- to 7-day shelf life. Cryopreserved platelets last up to 2 years and may improve availability, although their cost-effectiveness remains uncertain. Objective: To evaluate …

au (code pays fourni par la source)

Individualised treatment effects of enhanced early mobilisation in mechanically ventilated patients: a secondary analysis of the TEAM trial

Carol Hodgson, Alexandra B. Spicer, Tessa Broadley, Michael Bailey et autres

PURPOSE: Benefit or harm from early mobilisation (EM) in mechanically ventilated patients may vary by individual patient characteristics. We used machine learning to predict individualised treatment effects (ITEs) in the "Early Active Mobilization during Mechanical Ventilation in the ICU" (TEAM) trial. METHODS: …

au, cn, us, ie, gb, nz, de, at (code pays fourni par la source)

The intensive care medicine research agenda for the management of ICU acquired weakness: a multinational, interprofessional perspective

Sabrina Eggmann, Selina M. Parry, Tessa Broadley, Gordon S. Lynch et autres

ch, au, gb, us, Afrique du Sud, be, ca, in, de, se, at, br, cn (code pays fourni par la source)

Mortality trends for sepsis and septic shock among critically ill adults in Australia and New Zealand

Alexis Poole, Anis Chaba, Rinaldo Bellomo, Michael Bailey et autres

au, br, nz (code pays fourni par la source)

The cost-effectiveness of mild hypercapnia after out-of-hospital cardiac arrest: a health economic evaluation alongside the TAME study

Yong Yi Lee, Glenn M. Eastwood, Michael Bailey, Rinaldo Bellomo et autres

BACKGROUND: Out of hospital cardiac arrest (OHCA) is a significant public health problem associated with high mortality and high healthcare costs. The Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) randomised clinical trial showed that targeted mild hypercapnia did not lead …

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