Grigorii Nos

SRHgroup/ITRAP2: Version 1.0.1

Grigorii Nos

ITRAP2 is niw publicly available as a Seurat-integrated R package

SRHgroup/ITRAP2: Version 1.0.1

Grigorii Nos

ITRAP2 is niw publicly available as a Seurat-integrated R package

Antigen-scaffolds loaded with hyper-stable neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy

Maria Ormhøj, Kamilla Kjærgaard Munk, Siri Amanda Tvingsholm, Keerthana Ramanathan et autres

Abstract Adoptive cell therapy (ACT) has shown promising results in cancer treatment, however, achieving effective ex vivo expansion of potent, functionally active, and cytotoxic T cells remains challenging. To overcome this, we loaded the engineered cytokine Neoleukin-2/15 (Neo2/15) on our recently established …

dk (code pays fourni par la source)

Antigen-scaffolds loaded with hyper-stable neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy

Maria Ormhøj, Kamilla Kjærgaard Munk, Siri Tvingsholm (761202), Keerthana Ramanathan et autres

Introduction – Adoptive cell therapy (ACT) has shown promising results in cancer treatment, however, achieving effective ex vivo expansion of potent, functionally active, and cytotoxic T cells remains challenging. To address this challenge, we recently developed artificial antigen-presenting scaffolds (Ag-scaffolds) capable of …

id, dk (code pays fourni par la source)

ITRAP2, a flexible and robust strategy to assign antigen recognition of T-cells in coupled single-cell TCR-pMHC assay

Grigorii Nos, Amalie Kai Bentzen, Marie Christine Viuff, Kristoffer Haurum Johansen et autres

Abstract Determining T-cell specificity forms a crucial step toward understanding T-cell involvement in health and disease. Single-cell sequencing technologies allow for co-capture of TCR alpha and beta chains, and their antigen specificity can be determined through peptide-MHC (pMHC) multimer binding and capture …

dk (code pays fourni par la source)

Fibroblast diversity within human gut-associated lymphoid tissues

Urs Mörbe, Fredrik Junghus, Grigorii Nos, Peter Leth Jørgensen et autres

Gut-associated lymphoid tissues (GALT) represent major sites of adaptive immune priming in the intestine, yet our understanding of human GALT diversity and function remains limited. Here, we used single-cell RNA sequencing, flow cytometry, and confocal laser microscopy to map the fibroblast (FB) …

dk, se (code pays fourni par la source)

Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope set

Nikolaj Pagh Kristensen, Edoardo Dionisio, Amalie Kai Bentzen, Tripti Tamhane et autres

CD8 T cells provide immunity to virus infection through recognition of epitopes presented by peptide major histocompatibility complexes (pMHCs). To establish a concise panel of widely recognized T cell epitopes from common viruses, we combined analysis of TCR down-regulation upon stimulation with …

dk, us (code pays fourni par la source)

Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope set

Nikolaj Pagh Kristensen, Edoardo Dionisio, Amalie Kai Bentzen, Tripti Tamhane et autres

Abstract Knowledge of widely recognized T-cell epitopes against common virus infections are vital for immune monitoring and characterization of relevant antigen-specific CD8 T cells and their antigen receptors. We therefore aimed to establish a concise and validated epitope panel for monitoring human …

dk, us (code pays fourni par la source)

Data from Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures

Nikita Kotlov, Alexander Bagaev, Maria Victoria Revuelta, Jude M. Phillip et autres

Abstract Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease. Transcriptomic and genetic characterization of DLBCL has increased the understanding of its intrinsic pathogenesis and provided potential therapeutic targets. However, the role of the microenvironment in DLBCL biology remains …

Supplementary Figures from Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures

Nikita Kotlov, Alexander Bagaev, Maria Victoria Revuelta, Jude M. Phillip et autres

Supplementary Figures

Supplementary Figures from Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures

Nikita Kotlov, Alexander Bagaev, Maria Victoria Revuelta, Jude M. Phillip et autres

Supplementary Figures

Data from Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures

Nikita Kotlov, Alexander Bagaev, Maria Victoria Revuelta, Jude M. Phillip et autres

Abstract Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease. Transcriptomic and genetic characterization of DLBCL has increased the understanding of its intrinsic pathogenesis and provided potential therapeutic targets. However, the role of the microenvironment in DLBCL biology remains …