Piyush Kumar

AI-POWERED DRUG REPURPOSING: A NOVEL APPROACH TO ACCELERATE DRUG DEVELOPMENT

Mahvish Akhlaqe, Kuldeep Singh, Arun Kumar, Shom Prakash Kushwaha et autres

The conventional drug development pipeline is expensive, time-consuming, and prone to failure. Artificial intelligence (AI) aids in drug repurposing by allowing for the prompt discovery of previously unknown therapeutic uses for approved drugs. This manuscript examines AI approaches used in drug repurposing, …

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Role of Serum Amylase Levels in Blunt Abdominal Trauma to Diagnose Pancreatic Injury – A Retrospective Record Based Study

Divyanshu Gupta, Pandarinath Audi, Piyush Kumar, Pragya Sharma et autres

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Therapeutic potential of N-acetylcysteine in epilepsy: A systematic review

S.K. Sharma, Sanjeev Kumar Jain, Prerana Gupta, Piyush Kumar

Background: Epilepsy is a long-term neurological disorder that is defined by repeated seizures, often resistant to standard anti-seizure medications. Oxidative stress, mitochondrial impairment, and neuroinflammation are central to epileptogenesis. N-acetylcysteine (NAC), an antioxidant and glutathione precursor, was shown to possess potential neuroprotective …

Intensity-modulated Radiotherapy Versus Volumetric Modulated Arc Therapy in Head and Neck Cancers: A Comparative Analysis of Compliance, Toxicities and Dosimetric Parameters

Sanyamita Jain, Piyush Kumar, P. Vijay Kumar, Jitendra Nigam et autres

Introduction Intensity-modulated radiotherapy (IMRT) is now a standard technique to treat head and neck cancers. Another advanced technique - volumetric-modulated arc therapy (VMAT) - is gaining popularity due to rapid treatment delivery, which allows patient comfort and reduced intrafraction motion. The present …

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Estimation of Age from Fusion of Cranial Sutures by Computerized Tomography (CT) Examination

G. Raja, Pannag S. Kumar, Piyush Kumar, A. Fernandes et autres

Age estimation plays a critical role in forensic identification, particularly for legal and administrative purposes. Traditionally, age estimation relied on visual examination of cranial sutures, but modern radiological imaging techniques like computerized tomography (CT) scans have enhanced accuracy. This study aimed to …

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Mitigating Stiction Failures in In-use M/NEMS-based Sensors using a Reliable Piezoelectric RESET Mechanism

Khanjan Joshi, Dhairya Singh Arya, Manu Garg, Piyush Kumar et autres

This paper presents a reliable piezoelectric RESET mechanism designed to overcome stiction in MEMS-based sensors during operation. In addition to addressing stiction, the proposed RESET mechanism serves as a beam stop during excessive vibrations or acceleration, preventing further damage to the suspended …

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A method for eco-friendly transactions

Ramanpreet Kaur, Jaskirat Kaur, Gurmeet Kaur, Piyush Kumar

The global concern for health and environment has provided with technological solution for green and eco-friendly practices. In the need to meet sustainable development goals, several guidelines have been proposed by different agencies. In the quest for sustainable retail operations, the present …

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High Capacitive Ratio Molybdenum-based RF MEMS Capacitive Shunt Switch using Reduced Fabrication Steps

Nihaika Narang, Piyush Kumar, Pranav Kumar Shrivastava, Ananjan Basu et autres

This paper presents the design and fabrication of a high-performance molybdenum-based capacitive Radio Frequency Micro-Electro-Mechanical-Systems (RF MEMS) shunt switch. Molybdenum offers high robustness against stress and temperature compared to gold. The measured results show that switches provide return loss better than 15.05dB, …

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Electrothermal analysis of a simple MEMS Pirani Gauge with a lower detection limit

Ashwini Kumari, Manu Garg, Piyush Kumar, Pushpapraj Singh

This work presents a suspended serpentine micro-Pirani gauge for the detection of vacuum levels inside a microcavity. The electrothermal analysis of the proposed design is performed to find the dynamic range using the finite element analysis (FEA) tool, COMSOL Multiphysics®. The dynamic …

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Design of High Isolation Low Loss MEMS Ohmic Switch for Radio Frequency Applications

Piyush Kumar, Niharika Narang, Ashok Kumar Dhakar, Ashwini Kumari et autres

In this work, three vertical electrostatic RF-MEMS (Radio Frequency Micro Electro-Mechanical Switch) switch designs with shunt ohmic configurations and control voltages of approximately 13 V are proposed. We have examined the switch’s performance across a broad frequency range, from 1 to 100 …

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Super-hydrophilic LaCoO 3 /g-C 3 N 4 nanocomposite coated beauty sponge for solar-driven seawater desalination with simultaneous volatile organic compound removal

Lokesh Kumar Rathore, Parul Garg, Piyush Kumar, Ashok Bera

under 1 sun irradiation. This LCO/g-CN@BS shows excellent seawater desalination capacity with a self-cleaning ability when employed for saltwater purification for a salt (NaCl) concentration as high as 15 wt%. Moreover, fast photocarrier transfer between LCO and g-CN leads to enhanced photocatalytic …

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Phenylthiazolidin-4-one piperazine Conjugates: Design, Synthesis, anticancer and antimicrobial studies

Dalbir Singh, Rajiv M. Patel, A.K. Aggarwal, Anwesha Das et autres

In current research study, a series of ten novel phenylthiazolidin-4-one glycinamide conjugates with piperazines compounds (7a-j) were designed by combining the crucial pharmacophoric features from the reported potential anticancer hit molecules, subsequently evaluated for the drug-likeness behaviour. Designed candidates were synthesized, purified, …

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