Vasco D. B. Bonifácio

Supercritical CO2–Driven Design of Beryllium Molecularly Imprinted Polymers for Thermal Biosensors

Ana I. Furtado, Sérgio F. Sousa, Bart van Grinsven, Joseph W. Lowdon et autres

Abstract Supercritical carbon dioxide (scCO2) offers a sustainable medium for molecularly imprinted polymer (MIP) synthesis, yet rational monomer selection under supercritical conditions remains largely unexplored. Here, molecular dynamics (MD) simulations were used as a pre–polymerization screening tool to investigate template–monomer interactions for …

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Fatty acid and cysteine metabolic interplay regulate ferroptosis and highlight xCT as a selenium‐chrysin target in breast carcinoma

Ana Hipólito, Bruna Abreu, Joana Gonçalves, Fernanda Silva et autres

Abstract Cancer metabolic remodeling impacts the entire network of metabolic pathways, and strategies that target various points within this system could contribute to successfully abrogating cancer cell survival. Fatty acids (FAs) are essential to cancer cells because they support membrane biosynthesis during …

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Lipid Remodeling and Metabolic Adaptation in Cancer Cell Membranes: A Platform for Membrane-Targeted Nanotherapy

Adriana Cruz, Vasco D. B. Bonifácio

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Ball-Milling-Assisted Coating and Magnetic Properties of Fluorescent Biodegradable Powders for Fingerprint Detection

Hélio L. Barros, Nuno Martinho, Susana Cardoso, Vasco D. B. Bonifácio

The development of environmentally friendly materials for forensic applications is a growing area of interest. Traditional forensic methods often rely on resource-intensive processes and hazardous materials, and thus a demand for sustainable efficient materials without compromising performance is needed. Fluorescent, regular and …

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Author response for "Designing anticancer polyurea biodendrimers: The role of core-shell charge/hydrophobicity modulation"

Adriana Cruz, José Elpídio Barbosa, Nuno Bernardes, Beatriz Avó et autres

Author response for "Unlocking the potential of extracellular vesicles: One stimulus away from clinical implementation"

Ricardo Marques e Silva, Vasco D. B. Bonifácio, Sandra N. Pinto, Ana Margarida Azevedo et autres

Metabolism-targeted therapy in NSCLC – A new theranostics inhalation approach using lactate functionalized and selenium-chrysin loaded nanoparticles (SeChry@PUREG4-LA24)

Cindy Mendes, Filipa Martins, Sara Granja, Joana Gonçalves et autres

Lung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer …

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Correction: Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolism-based strategy to impair glioblastoma (GBM)

Filipa Martins, Renata Arada, Hélio L. Barros, Paulo Victor Lima De Matos et autres

The article 'Lactate-coated polyurea-siRNA dendriplex: a gene therapy directed and metabolism-based strategy to impair glioblastoma (GBM)', written by Filipa Martins, Renata Arada, Hélio Barros, Paulo Matos, José Ramalho, Valentín Ceña, Vasco D. B. Bonifácio, Luís G. Gonçalves and Jacinta Serpa, was originally …

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Mechanosynthesis of optically stable fluorescent magnetic microparticles tailored for detection of latent fingerprints

Hélio L. Barros, Emília P. T. Leitão, Aladdin Mardanov, Ana I. Furtado et autres

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In Vivo Antimicrobial Activity of Nisin Z Against S. aureus and Polyurea Pharmadendrimer PUREG4OEI48 Against P. aeruginosa from Diabetic Foot Infections

Isa D. Serrano, Dalila Mil‐Homens, Rita F. Pires, Vasco D. B. Bonifácio et autres

Background/Objectives: Diabetic foot infections (DFIs) are commonly associated with frequent hospitalizations, limb amputations, and premature death due to the profile of the bacteria infecting foot ulcers. DFIs are generally colonized by a polymicrobial net of bacteria that grows in biofilms, developing an …

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Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolism-based strategy to impair glioblastoma (GBM)

Filipa Martins, Renata Arada, Hélio L. Barros, Paulo Victor Lima De Matos et autres

Glioblastoma (GBM) is a highly lethal disease with limited treatment options due to its infiltrative nature and the lack of efficient therapy able to cross the protective blood-brain barrier (BBB). GBMs are metabolically characterized by increased glycolysis and glutamine dependence. This study …

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XXVIII Encontro Galego-Português de Química

Joaquim Luís Faria, Vasco D. B. Bonifácio

Ex-Presidente da IUPAC (2022)(2023), recebeu o Prémio Nacional de Investigação "Juan de la Cierva" e o Prémio Rei Jaime I em Novas Tecnologias.É fundador da Rive Technology, que comercializa catalisadores para refinarias, promovendo eficiência energética e redução de emissões de CO 2 …