Supplemental materials for PAC1 deficiency protects immobilization-induced muscle atrophy in obese male mice by suppressing FoxO-atrogene axis.docx

Le résumé fourni par la source

Supplemental materials, including gene set enrichment analysis data and others. Muscle atrophy is the cause and consequence of obesity. Proteasome dysfunction mediates obesity-induced endoplasmic reticulum (ER) stress and insulin resistance in the liver and adipose tissues. However, obesity-associated regulation of proteasome function and its role in the skeletal muscles remains under-investigated. Here, we established skeletal muscle-specific 20S proteasome assembly chaperone-1 (PAC1) knockout (mPAC1KO) mice.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.