Edward B. Kaczmarski

The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent Adults (vol 72, pg 405, 2016)

Fiona McGill, Robert S. Heyderman, Benedict Michael, Sylviane Defres et autres

Corrigendum to “The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent Adults” [J Infect 72 (2016) 405–438]

Fiona McGill, Robert S. Heyderman, Benedict Michael, Sylviane Defres et autres

The authors regret the following footnote should have been included with Table 6: In cases where Chloramphenicol is used (known anaphylaxis to penicillins or cephalosporins) the dose may be reduced to 12.5 mg/kg 6 hourly if the patient is recovering, to reduce …

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The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults

Fiona McGill, Robert S. Heyderman, Benedict Michael, Sylviane Defres et autres

Bacterial meningitis and meningococcal sepsis are rare conditions with high case fatality rates. Early recognition and prompt treatment saves lives. In 1999 the British Infection Society produced a consensus statement for the management of immunocompetent adults with meningitis and meningococcal sepsis. Since …

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Reduced turnaround time and improved diagnosis of invasive serogroup B Neisseria meningitidis and Streptococcus pneumoniae infections using a lyophilized quadruplex quantitative PCR

M. McHugh, Steve Gray, Edward B. Kaczmarski, Malcolm Guiver

Since 1996 the Meningococcal Reference Unit (MRU) in Manchester has provided a national service for PCR confirmation of meningococcal and pneumococcal disease. Neisseria meningitidis serogroup B is predominant in the UK, accounting for >60% of cases. In response to this, the MRU …

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Investigation into the Antigenic Properties and Contributions to Growth in Blood of the Meningococcal Haemoglobin Receptors, HpuAB and HmbR

Fadil A. Bidmos, Hannah Chan, Uta Praekelt, Isfahan Tauseef et autres

Acquisition of iron from host complexes is mediated by four surface-located receptors of Neisseria meningitidis. The HmbR protein and heterodimeric HpuAB complex bind to haemoglobin whilst TbpBA and LbpBA bind iron-loaded transferrin and lactoferrin complexes, respectively. The haemoglobin receptors are unevenly distributed; …

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Variations inNeisseria meningitidiscarriage by socioeconomic status: a cross-sectional study

Paul Cleary, N Calvert, Sarah Gee, Christine Graham et autres

BACKGROUND: Deprivation is associated with an increased risk of invasive Neisseria meningitidis disease, but little is known about the relationship between deprivation and asymptomatic carriage of N. meningitidis. This analysis was conducted to examine the relationship between meningococcal carriage and deprivation. METHODS: …

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MBL2 deficiency is associated with higher genomic bacterial loads during meningococcemia in young children

Thomas C. Darton, Dominic Jack, Marina Johnson, Ray Borrow et autres

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The Distribution and ‘In Vivo’ Phase Variation Status of Haemoglobin Receptors in Invasive Meningococcal Serogroup B Disease: Genotypic and Phenotypic Analysis

Jay Lucidarme, Jamie Findlow, Hannah Chan, Ian M. Feavers et autres

Two haemoglobin-binding proteins, HmbR and HpuAB, contribute to iron acquisition by Neisseria meningitidis. These receptors are subject to high frequency, reversible switches in gene expression--phase variation (PV)--due to mutations in homopolymeric (poly-G) repeats present in the open reading frame. The distribution and …

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Genetic Distribution of Noncapsular Meningococcal Group B Vaccine Antigens in Neisseria lactamica

Jay Lucidarme, Stefanie Gilchrist, Lynne S. Newbold, Stephen J. Gray et autres

The poor immunogenicity of the meningococcal serogroup B (MenB) capsule has led to the development of vaccines targeting subcapsular antigens, in particular the immunodominant and diverse outer membrane porin, PorA. These vaccines are largely strain specific; however, they offer limited protection against …

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Invasive meningococcal disease in England and Wales: Implications for the introduction of new vaccines

Shamez Ladhani, Jessica Flood, Mary Ramsay, Helen Campbell et autres

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Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009

Shamez Ladhani, Jay Lucidarme, Lynne S. Newbold, Stephen J. Gray et autres

ABCs Areas California (3 county San Francisco Bay area); Colorado (5 county Denver area); Connecticut; Georgia; Maryland; Minnesota; New Mexico; New York (15 county Rochester and Albany areas); Oregon; Tennessee (11 urban counties) ABCs Population The surveillance areas represent 41,261,719 persons.Source: National …

Changes in Serogroup and Genotype Prevalence Among Carried Meningococci in the United Kingdom During Vaccine Implementation

Ana Belén Ibarz-Pavón, Jenny MacLennan, Nicholas Andrews, Stephen J. Gray et autres

BACKGROUND: Herd immunity is important in the effectiveness of conjugate polysaccharide vaccines against encapsulated bacteria. A large multicenter study investigated the effect of meningococcal serogroup C conjugate vaccine introduction on the meningococcal population. METHODS: Carried meningococci in individuals aged 15-19 years attending …

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