Jenny M. MacLennan

Controlled Human Infection of Healthy Adults With Lyophilized Neisseria lactamica Induces Asymptomatic, Immunogenic Nasopharyngeal Carriage in the United Kingdom and Mali

D F Gbesemete, Fadima Cheick Haidara, J R Laver, M Ibrahim et autres

Abstract Background Carriage of Neisseria lactamica (Nlac), a harmless nasopharyngeal commensal, correlates inversely with carriage of Neisseria meningitidis (Nmen), a common cause of meningitis and sepsis outbreaks in sub-Saharan Africa. Nasally administered lyophilized Nlac (LyoNlac) might interrupt carriage and transmission of Nmen …

gb, Mali, ca, us (code pays fourni par la source)

Impact of meningococcal ACWY conjugate vaccines on pharyngeal carriage in adolescents: evidence for herd protection from the UK MenACWY programme

Jeremy Peter James Carr, Jenny M. MacLennan, Emma Plested, Holly B. Bratcher et autres

OBJECTIVE: Serogroup W and Y invasive meningococcal disease increased globally from 2000 onwards. Responding to a rapid increase in serogroup W clonal complex 11 (W:cc11) invasive meningococcal disease, the UK replaced an adolescent booster dose of meningococcal C conjugate vaccine with quadrivalent …

gb, au (code pays fourni par la source)

B Part of It School Leaver Study: A Repeat Cross-Sectional Study to Assess the Impact of Increasing Coverage With Meningococcal B (4CMenB) Vaccine on Carriage of Neisseria meningitidis

Mark McMillan, Ann P. Koehler, Andrew John Lawrence, Thomas Sullivan et autres

BACKGROUND: Recombinant protein-based vaccines targeting serogroup B meningococci protect against invasive disease but impacts on carriage are uncertain. This study assessed carriage prevalence of disease-associated meningococci in 2018-2020 as the proportion of vaccinated adolescents increased following introduction of a school-based 4CMenB immunization …

au, gb, nl (code pays fourni par la source)

Meningococcal carriage in periods of high and low invasive meningococcal disease incidence in the UK: comparison of UKMenCar1–4 cross-sectional survey results

Jenny M. MacLennan, Charlene M.C. Rodrigues, Holly B. Bratcher, Aiswarya Lekshmi et autres

BACKGROUND: The incidence of invasive meningococcal disease in the UK decreased by approximately four times from 1999 to 2014, with reductions in serogroup C and serogroup B disease. Lower serogroup C invasive meningococcal disease incidence was attributable to implementation of the meningococcal …

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Meningococcal carriage in periods of high and low invasive meningococcal disease incidence in the United Kingdom – a cross-sectional, observational survey.

Martin C. J. Maiden, Jenny M. MacLennan, Rodrigues Cmc., Holly B. Bratcher et autres

‘Be on the TEAM’ Study (Teenagers Against Meningitis): protocol for a controlled clinical trial evaluating the impact of 4CMenB or MenB-fHbp vaccination on the pharyngeal carriage of meningococci in adolescents

Jeremy Carr, Emma Plested, Parvinder K. Aley, Susana Camara et autres

Introduction Capsular group B Neisseria meningitidis (MenB) is the most common cause of invasive meningococcal disease (IMD) in many parts of the world. A MenB vaccine directed against the polysaccharide capsule remains elusive due to poor immunogenicity and safety concerns. The vaccines …

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The global meningitis genome partnership

Elizabeth A. Rodgers, Stephen D. Bentley, Ray Borrow, Holly B. Bratcher et autres

Genomic surveillance of bacterial meningitis pathogens is essential for effective disease control globally, enabling identification of emerging and expanding strains and consequent public health interventions. While there has been a rise in the use of whole genome sequencing, this has been driven …

gb, fr, no, us, in, ch, nl, es, bn (code pays fourni par la source)

Microbial Genomic Data Analysis for Infectious Diseases

Martin C. J. Maiden, Mónika Varga, Carina Rodrigues, K Jolley et autres

Meningococcal B Vaccine and Meningococcal Carriage in Adolescents in Australia

Helen Siobhan Marshall, Mark McMillan, Ann P. Koehler, Andrew John Lawrence et autres

BACKGROUNDThe meningococcal group B vaccine 4CMenB is a new, recombinant protein-based vaccine that is licensed to protect against invasive group B meningococcal disease.However, its role in preventing transmission and, therefore, inducing population (herd) protection is uncertain. METHODSWe used cluster randomization to assign, …

au, gb, in, us (code pays fourni par la source)

UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence

Holly B. Bratcher, Charlene M.C. Rodrigues, Adam H.R. Finn, Mandy Wootton et autres

, the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx of ~10% of the …

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Genomic characterization of novel Neisseria species

Kanny Diallo, Jenny M. MacLennan, Odile Barbara Harrison, Chisomo Lawrence Msefula et autres

Of the ten human-restricted Neisseria species two, Neisseria meningitidis, and Neisseria gonorrhoeae, cause invasive disease: the other eight are carried asymptomatically in the pharynx, possibly modulating meningococcal and gonococcal infections. Consequently, characterizing their diversity is important for understanding the microbiome in health …

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UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence

Holly B. Bratcher, Charlene M.C. Rodrigues, Adam H.R. Finn, Mandy Wootton et autres

Carriage of Neisseria meningitidis , the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx …

gb (code pays fourni par la source)