Sayeda N Abu-Amero

Genetic analyses in small-for-gestational-age newborns

Stalman SE, Nita Solanky, Minoru Ishida, Cristina Alemán-Charlet et autres

SGA is often defined as a birth weight and/or length < −2 SDS for gestational age and gender [43]. A frequent cause of SGA is fetal growth restriction (FGR), often associated with perinatal mortality and morbidity and also implicated in a higher …

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Genetic Analyses in Small-for-Gestational-Age Newborns

Susanne E. Stalman, Nita Solanky, Miho Ishida, Cristina Alemán-Charlet et autres

Context: Small for gestational age (SGA) can be the result of fetal growth restriction, which is associated with perinatal morbidity and mortality. Mechanisms that control prenatal growth are poorly understood. Objective: The aim of the current study was to gain more insight …

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A new biological and clinical resource for research into pregnancy complications: The Baby Bio Bank

Lydia J. Leon, Nita Solanky, Susanne E. Stalman, Charalambos Demetriou et autres

About 20% of pregnancies are affected by some form of complication. Research has shown that anomalies in implantation, development, and growth of the fetus; ineffective nutrient exchange between mother and fetus due to placental dysfunction; and maternal problems such as hypertension or …

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Erratum to: Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models

Maite Mendióroz, Catherine Do, Xiaoling Jiang, Chunhong Liu et autres

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Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models

Maite Mendióroz, Catherine Do, Xiaoling Jiang, Chunhong Liu et autres

BACKGROUND: Trisomy 21 causes Down syndrome (DS), but the mechanisms by which the extra chromosome leads to deficient intellectual and immune function are not well understood. RESULTS: Here, we profile CpG methylation in DS and control cerebral and cerebellar cortex of adults …

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Investigation of the Annexin A5 M2 haplotype in 500 white European couples who have experienced recurrent spontaneous abortion

Charalambos Demetriou, Sayeda N Abu-Amero, Shawnelle White, Emma Peskett et autres

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The role and interaction of imprinted genes in human fetal growth

Gudrun E. Moore, Miho Ishida, Charalambos Demetriou, Lara Al-Olabi et autres

Identifying the genetic input for fetal growth will help to understand common, serious complications of pregnancy such as fetal growth restriction. Genomic imprinting is an epigenetic process that silences one parental allele, resulting in monoallelic expression. Imprinted genes are important in mammalian …

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Genome-wide methylation analysis in Silver–Russell syndrome patients

Adam R. Prickett, Miho Ishida, Stefanie Böhm, Jennifer M. Frost et autres

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Paternally Expressed, Imprinted Insulin-Like Growth Factor-2 in Chorionic Villi Correlates Significantly with Birth Weight

Charalambos Demetriou, Sayeda N Abu-Amero, Anna C. Thomas, Miho Ishida et autres

CONTEXT: Fetal growth involves highly complex molecular pathways. IGF2 is a key paternally expressed growth hormone that is critical for in utero growth in mice. Its role in human fetal growth has remained ambiguous, as it has only been studied in term …

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Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight

Charalambos Demetriou, Sayeda N Abu-Amero, Miho Ishida, Renuka Aggarwal et autres

Fetal growth involves highly complex molecular pathways. IGF2 is a key paternally expressed growth hormone that is critical for in utero growth in mice. Its role in human fetal growth has remained ambiguous, as it has only been studied in term tissues. …

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Faculty Opinions recommendation of Central precocious puberty caused by mutations in the imprinted gene MKRN3.

Sue Malcolm, Sayeda N Abu-Amero

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Imprinted Chromatin around DIRAS3 Regulates Alternative Splicing of GNG12-AS1, a Long Noncoding RNA

Malwina Niemczyk, Yoko Itō, Joanna E. Huddleston, Anna Git et autres

Imprinted gene clusters are regulated by long noncoding RNAs (lncRNAs), CCCTC binding factor (CTCF)-mediated boundaries, and DNA methylation. DIRAS3 (also known as ARH1 or NOEY1) is an imprinted gene encoding a protein belonging to the RAS superfamily of GTPases and is located …

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