Daniel Styburski

Multi-strain probiotic enhances metformin tolerance by modulating gut microbiome and bile acid pathways: Insight from multi-omics post-hoc analysis (ProGasMet trial)

Hanna Kwiendacz, Danuta Cembrowska-Lech, Karolina Skonieczna‐Żydecka, Karolina Klimontowicz et autres

BACKGROUND: Metformin is the cornerstone therapy for type 2 diabetes, but gastrointestinal intolerance commonly limits dose escalation and long-term adherence. In the ProGasMet trial, multi-strain probiotic supplementation improved metformin tolerability. However, the underlying microbiome-metabolome mechanisms remain unclear. METHODS AND ANALYSIS: We performed …

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Multi-strain probiotic enhances metformin tolerance by modulating gut microbiome and bile acid pathways: Insight from multi-omics post-hoc analysis (ProGasMet trial)

Hanna Kwiendacz, Danuta Cembrowska-Lech, Karolina Skonieczna‐Żydecka, Karolina Klimontowicz et autres

Abstract Background Metformin is the cornerstone therapy for type 2 diabetes, but gastrointestinal intolerance commonly limits dose escalation and long-term adherence. In the ProGasMet trial, multi-strain probiotic supplementation improved metformin tolerability. However, the underlying microbiome-metabolome mechanisms remain unclear. Methods and analysis We …

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The Relationship Between Short-Chain Fatty Acid Secretion and Polymorphisms rs3894326 and rs778986 of the FUT3 Gene in Patients with Multiple Sclerosis—An Exploratory Analysis

Monika Kulaszyńska, Wiktoria Czarnecka, Natalia Jakubiak, Daniel Styburski et autres

Background: The intestinal microflora is a population of microorganisms that resides in the human gastrointestinal tract and is important in maintaining metabolic and immune homeostasis in the body. Bacteria residing in the intestine produce short-chain fatty acids (SCFAs), which communicate with, among …

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Influence of dietary supplementation with two distinct probiotic strains, Bifidobacterium longum R0175 and Lacticaseibacillus rhamnosus JB-1, on seizure susceptibility and valproate response: Behavioral and biochemical studies in mice

Piotr Właź, Karolina Skonieczna‐Żydecka, Adrian Wiater, Daniel Styburski et autres

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A Randomized Controlled Trial Evaluating the Effects of a Probiotic Containing Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 on Gastrointestinal Symptoms and Metabolomic Profiles in Female Dancers

Jakub Wiącek, Karolina Skonieczna‐Żydecka, Igor Łoniewski, Daniel Styburski et autres

Dancers experience physical and psychological stressors that can impact gut health. We hypothesized that a three-month supplementation with Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 would result in measurable alterations in the fecal metabolomic profile and improve gastrointestinal symptomatology in dancers. Of …

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Rewriting the urinary tract paradigm: the urobiome as a gatekeeper of host defense

Agnieszka Pastuszka, Szymon Tobor, Igor Łoniewski, Anna Wierzbicka-Woś et autres

The urobiome, or urinary tract microbiome, has emerged as a crucial component in maintaining urinary health and defending against infections. Recent advances in next-generation sequencing (NGS) have debunked the long-held belief that the urinary tract is sterile, revealing a unique ecosystem of …

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Untargeted Metabolomic Profiling of Colonic Mucosa in Individuals with Irritable Bowel Syndrome

Patrycja Krynicka, Mariusz Kaczmarczyk, Karolina Skonieczna‐Żydecka, Daniel Styburski et autres

Background: Irritable Bowel Syndrome (IBS) is a complex disorder characterized by altered gut–brain interactions, with gastrointestinal microbiota and metabolic dysregulation playing key roles in its pathophysiology. Identifying specific metabolic alterations within the colonic mucosa may enhance our understanding of IBS and contribute …

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Untargeted Metabolomic Profiling of Colonic Mucosa in Individuals with Irritable Bowel Syndrome

Patrycja Krynicka, Mariusz Kaczmarczyk, Karolina Skonieczna‐Żydecka, Daniel Styburski et autres

Background: Irritable Bowel Syndrome (IBS) is a complex disorder characterised by altered gut-brain interactions, with gastrointestinal microbiota and metabolic dysregulation playing key roles in its pathophysiology. Identifying specific metabolic alterations within the colonic mucosa may enhance our understanding of IBS and contribute …

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The associations between nutrition and circulating gut microbiota-derived uremic toxins in patients undergoing kidney replacement therapy: An observational, cross-sectional study

Sylwia Czaja-Stolc, Marta Potrykus, Jakub Ruszkowski, Daniel Styburski et autres

BACKGROUND: Gut microbiota generates a series of bioactive metabolites that can be converted into uremic toxins such as trimethylamine-N-oxide (TMAO), p-cresyl sulfate (pCS), and indoxyl sulfate (IS). The aim of the study was to examine the association between diet and the concentrations …

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Untargeted metabolomics in gastric and colorectal cancer patients – preliminary results

Karolina Kaźmierczak-Siedlecka, Damian Muszyński, Daniel Styburski, Jakub Makarewicz et autres

Introduction: Recent years, microbiota-associated aspects have been analysed in multiple disorders regarding cancers. Existing evidence pints that gut microorganisms might take part in tumour origin and therapy efficacy. Nevertheless, to date, data on faecal metabolomics in cancer patients is still strongly limited. …

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Altered lipid metabolism in patients with acute graft-versus-host disease after allogeneic hematopoietic cell transplantation

Martyna Tyszka, Dominika Maciejewska, Daniel Styburski, Jarosław Biliński et autres

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Multispecies probiotic affects fecal short-chain fatty acids in postmenopausal women with obesity: A post hoc analysis of a randomized, double-blind, placebo-controlled study

Igor Łoniewski, Monika Szulińska, Mariusz Kaczmarczyk, Konrad Podsiadło et autres

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