Wenxin Tang

Higher frequencies of CNV deletions in bipolar disorder among Chinese Population

Yong Wu, Xiangyu Li, Yaoyao Sun, Chuyi Zhang et autres

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Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery

Chuyi Zhang, Miao Li, Ping Xin Sun, Li Hui et autres

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The imperative for multigenerational genetic screening: A case report of fragile X-associated tremor/ataxia syndrome (FXTAS)

Yueqi Huang, Ziyang Huang, Zheng Wang, Wenxin Tang et autres

RATIONALE: Fragile X-associated tremor/ataxia syndrome (FXTAS), presenting with cognitive impairment as the initial symptom, is rare. This report emphasizes the need to consider FXTAS diagnosis in cases of early onset cognitive impairment in an aging population. PATIENT CONCERNS: A 57-year-old male with …

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The relationship between obsessive‒compulsive symptoms and parenting styles: The mediating effect of perfectionism

Yan Liang, Lian-Lian Xu, Yueqi Huang, Wenjing Zhu et autres

The development of obsessive‒compulsive disorder (OCD), a common psychiatric disorder with multiple dimensions, is closely related to parenting styles. Theoretical studies suggest that perfectionism may play a mediating role, but this has not been confirmed in patients with varied OCD symptoms, and …

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Functional Magnetic Resonance Imaging–Specific Alternations in the Default Mode Network in Obsessive-Compulsive Disorder: A Voxel-Based Meta-Analysis

Jianping Yu, Qianwen Xu, Lisha Ma, Yueqi Huang et autres

BACKGROUND: Obsessive-compulsive disorder (OCD) is a common and debilitating mental disorder. Neuroimaging studies have highlighted that a dysfunctional default mode network (DMN) plays a key role in the pathophysiological mechanisms of OCD. However, findings of impaired DMN regions in OCD have been …

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Corrigendum: Aberrant functional connectivity of sensorimotor network and its relationship with executive dysfunction in bipolar disorder type I

Wenjing Zhu, Wenxin Tang, Yan Liang, Xiaoying Jiang et autres

Corrigendum: Aberrant Functional Connectivity of Sensorimotor Network and Its Relationship With Executive Dysfunction in Bipolar Disorder Type IName of all authors as they appear in the published original article Affiliations of all authors as they appear in the published original version of …

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Continuous theta burst stimulation to relieve symptoms in patients with moderate obsessive-compulsive disorder: a preliminary study with an external validation

Ruiqing Ni, Yueling Liu, Jin Jiang, Wanying Zhang et autres

Obsessive-compulsive disorder (OCD) is a clinically challenging and refractory psychiatric disorder characterized by pathologically hyperactivated brain activity. Continuous theta burst stimulation (cTBS) is considered a potentially non-invasive treatment for inducing inhibitory effects on the underlying cortex. Numerous studies showed an unsatisfactory efficacy …

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Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis

Jianping Yu, Qianwen Xu, Lisha Ma, Yueqi Huang et autres

Background: Obsessive-compulsive disorder (OCD) is a chronic psychiatric illness with complex clinical manifestations. Cognitive dysfunction may underlie OC symptoms. The frontoparietal network (FPN) is a key region involved in cognitive control. However, the findings of impaired FPN regions have been inconsistent. We …

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Comparison of Disease Severity, Anxiety and Depression in Obsessive-Compulsive Disorder Patients with Different Insight.

Cheng Zhu, Yueqi Huang, Wenjing Zhu, Xiaoying Jiang et autres

BACKGROUND: Significant individual differences exist in the insight of patients with obsessive-compulsive disorder (OCD), and the clinical characteristics of OCD patients with varying levels of insight are not entirely uniform. This study aims to investigate disparities in disease severity, anxiety, and depression …

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Neuron-targeted overexpression of caveolin-1 alleviates diabetes-associated cognitive dysfunction via regulating mitochondrial fission-mitophagy axis

Wenxin Tang, Chaoying Yan, Shuxuan He, Mengyu Du et autres

BACKGROUND: Type 2 diabetes mellitus (T2DM) induced diabetes-associated cognitive dysfunction (DACD) that seriously affects the self-management of T2DM patients, is currently one of the most severe T2DM-associated complications, but the mechanistic basis remains unclear. Mitochondria are highly dynamic organelles, whose function refers …

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A Controlled Clinical Study of Accelerated High-Dose Theta Burst Stimulation in Patients with Obsessive–Compulsive Disorder

Jin Jiang, Ke Ming Wan, Yueling Liu, Yan Tang et autres

Background: Obsessive-compulsive disorder (OCD) is frequently treated using a combination of counseling, drugs, and, more recently various transcranial stimulation protocols, but all require several weeks to months for clinically significant improvement, so there is a need for treatments with faster onset. This …

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Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction

Yansong Li, Tao Jiang, Mengyu Du, Shuxuan He et autres

Dementia, as an advanced diabetes-associated cognitive dysfunction (DACD), has become the second leading cause of death among diabetes patients. Given that little guidance is currently available to address the DACD process, it is imperative to understand the underlying mechanisms and screen out …

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