Continuous theta burst stimulation to relieve symptoms in patients with moderate obsessive-compulsive disorder: a preliminary study with an external validation
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Le résumé fourni par la source
Obsessive-compulsive disorder (OCD) is a clinically challenging and refractory psychiatric disorder characterized by pathologically hyperactivated brain activity. Continuous theta burst stimulation (cTBS) is considered a potentially non-invasive treatment for inducing inhibitory effects on the underlying cortex. Numerous studies showed an unsatisfactory efficacy of cTBS for OCD. Accordingly, it seems that cTBS is ineffective for OCD. However, the neglect of varying OCD severities, modest sample size, absence of a multicenter design incorporating inpatients and outpatients, and lack of personalized imaging-guided targeting may constrain the conclusive findings of cTBS efficacy for OCD. In the preliminary experiment, 50 inpatients with OCD were enrolled to receive cTBS (10 sessions/day for five continuous days) or sham over the personalized right pre-supplementary motor area determined by the highest functional connectivity with the subthalamic nucleus according to our prior study. In the extension experiment, 32 outpatients with OCD received cTBS to generalize the treatment effects. The Yale-Brown Obsessive-Compulsive Scale (YBOCS) was assessed before and after treatment. In the preliminary experiment, the response rates in the cTBS group were 56.52%, respectively, significantly higher than those in the sham group. Further analysis revealed significant YBOCS improvement in patients with moderate OCD symptoms than those with severe OCD symptoms. In the extension experiment, the response rates were 50.00%. Additionally, a significant decrease in YBOCS scores was only found in patients with moderate OCD symptoms. This is the first study with an external validation design across two centers to identify OCD symptoms as playing an important role in cTBS treatment effects, especially in patients with moderate OCD symptoms.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Continuous theta burst stimulation to relieve symptoms in patients with moderate obsessive-compulsive disorder: a preliminary study with an external validation
- Date Crossref
- 06/08/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Anhui Medical University pays non établi dans la noticeUniversité ou école supérieure
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Imperial College London Department of Life Sciences pays non établi dans la noticeUniversité ou école supérieure
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Anhui Mental Health Center pays non établi dans la noticeÉtablissement de santé
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Hangzhou Seventh Peoples Hospital pays non établi dans la noticeStructure de recherche
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Zhejiang University Affiliated Mental Health Center & Hangzhou Seventh People's Hospital pays non établi dans la noticeUniversité ou école supérieure
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School of Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
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School of Mental Health and Psychological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders pays non établi dans la noticeStructure de recherche
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Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health pays non établi dans la noticeInstitution
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Institute of Artificial Intelligence pays non établi dans la noticeStructure de recherche
Anhui Medical University, Department of Life Sciences — Imperial College London et Anhui Mental Health Center, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.