Joris Michaud

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo-Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men.

Grith Westergaard Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog et autres

Muscle Stem Cells (MuSCs) drive muscle regeneration and slow pathological progression of muscle diseases. In preclinical models, nicotinamide (NAM) and pyridoxine (PN) synergistically increased MuSC proliferation and differentiation, and accelerated muscle regeneration. Herein we tested if NAM/PN could enhance MuSC activity and …

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Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men (Adv. Sci. 28/2026)

Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog et autres

Human Muscle Regeneration This frontispiece shows regenerating human skeletal muscle stained for embryonic myosin heavy chain (eMyHC) eight days after high intensity contraction and daily Nicotinamide and Pyridoxine supplementation. eMyHC-positive fibers mark newly formed myofibers arising from activated muscle stem cells. Nicotinamide …

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Grith Westergaard Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog et autres

Muscle Stem Cells (MuSCs) drive muscle regeneration and slow pathological progression of muscle diseases. In preclinical models, nicotinamide (NAM) and pyridoxine (PN) synergistically increased MuSC proliferation and differentiation, and accelerated muscle regeneration. Herein we tested if NAM/PN could enhance MuSC activity and …

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Nicotinamide and Pyridoxine supplementation stimulates muscle stem cells in a randomized clinical trial on muscle repair

Grith Westergaard Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog et autres

Abstract Skeletal muscle regeneration is a cardinal feature of muscle pathologies and is crucial for post-exercise recovery and traumatic sports injuries. Regeneration of damaged muscle in humans is a prolonged process and is accompanied by pain and physical dysfunction, highlighting the unmet …

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Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging

Sara Ancel, Joris Michaud, Eugenia Migliavacca, Charline Jomard et autres

Skeletal muscle relies on resident muscle stem cells (MuSCs) for growth and repair. Aging and muscle diseases impair MuSC function, leading to stem cell exhaustion and regenerative decline that contribute to the progressive loss of skeletal muscle mass and strength. In the …

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A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging

Sara Ancel, Joris Michaud, Federico Sizzano, Loïc Tauzin et autres

Increasing evidence suggests that the muscle stem cell (MuSC) pool is heterogeneous. In particular, a rare subset of PAX7-positive MuSCs that has never expressed the myogenic regulatory factor MYF5 displays unique self-renewal and engraftment characteristics. However, the scarcity and limited availability of …

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Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice

Emmeran Le Moal, Yuguo Liu, Jasmin Collerette-Tremblay, Simon Dumontier et autres

Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here, we showed that defects in the endothelial cell (EC) compartment of the vascular stem cell niche in mouse models of Duchenne …

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A Dual Color Pax7 and Myf5 In Vivo Reporter to Investigate Muscle Stem Cell Heterogeneity in Regeneration and Aging

Sara Ancel, Joris Michaud, Federico Sizzano, Loïc Tauzin et autres

Summary Increasing evidence suggests heterogeneity in the muscle stem cell (MuSC) pool. In particular, a rare subset of Pax7 positive MuSCs that has never expressed the myogenic regulatory factor Myf5 has enhanced self-renewal and engraftment characteristics. However, the scarcity and limited availability …

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Apelin Stimulation of the Perivascular MuSC Niche Enhances Endogenous Repair in Muscular Dystrophy

Emméran Le Moal, Yuguo Liu, Jasmin Collerette-Tremblay, Simon Dumontier et autres

Abstract Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here we describe that defects in the endothelial cell (EC) compartment of the perivascular stem cell niche in three different types …

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An engineered multicellular stem cell niche for the 3D derivation of human myogenic progenitors from iPSCs

Omid Mashinchian, Filippo De Franceschi, Sina Nassiri, Joris Michaud et autres

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Author response: In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

Omid Mashinchian, Xiaotong Hong, Joris Michaud, Eugenia Migliavacca et autres

Cell encapsulation-based transcriptional profiling using myogenic progenitors reveals that long-range factors in the aged systemic environment induce a wide range of signaling pathways in a niche-independent manner.

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In Vivo Transcriptomic Profiling using Cell Encapsulation Identifies Effector Pathways of Systemic Aging

Omid Mashinchian, Xiaotong Hong, Joris Michaud, Eugenia Migliavacca et autres

Abstract Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on specific cell populations. Here we describe a method …

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